Buy Aceclofenac pills 100 mg 20 pcs
  • Buy Aceclofenac pills 100 mg 20 pcs


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Clinical Pharmacology

Aceclofenac is a nonsteroidal anti-inflammatory agent derived from phenylacetic acid. Aceclofenac has analgesic, anti-inflammatory, antipyretic effects, which are associated with inhibition of cyclooxygenase 1 and 2, which regulate the production of prostaglandins. When taken inside, aceclofenac is well absorbed. The maximum concentration is reached in 1.25 - 3 hours. Aceclofenac enters the articular fluid, where its content reaches 57% of plasma concentrations, and the time maximum concentration is reached 2 to 4 hours longer than in plasma. The volume of distribution of aceclofenac is 25 liters. Plasma proteins (albumin) aceclofenac is 99% bound. Aceclofenac circulates mainly unchanged, its main metabolite is 4'-hydroxyaceclofenac. the half-life is 4 hours. Aceclofenac excreted by the kidneys, more than 60% in the form of hydroxy derivatives.


The drug is prescribed:

  • as part of the complex treatment of inflammatory diseases of the musculoskeletal system (osteoarthritis, rheumatoid, psoriatic and juvenile arthritis, paws, ankylosing spondylitis or spondylitis);
  • for the relief of pain and inflammation in rheumatism, toothache, scapulohumeral periarthritis.

The use of Aceclofenac is not able to completely cure these diseases, however, it quickly reduces inflammation and pain.


Active substances:

Aceclofenac - 100 mg


Core Composition:

Calcium stearate - 3 mg

Talc - 9 mg

Colloidal silicon dioxide (Aerosil) - 1.5 mg

Microcrystalline cellulose - 85 mg

Croscarmellose sodium (primelloza) - 10.5 mg

Lactose monohydrate (milk sugar) - 91 mg

Kernel mass - 300 mg

Shell composition:

Hypromellose (hydroxypropylmethylcellulose) - 6.4 mg

Macrogol - 4000 (polyethylene oxide-4000) - 2.5 mg

Titanium dioxide (titanium dioxide) - 1.1 mg

Tablet weight - 310 mg

Aceclofenac is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Aceclofenac pills
Alental Vertex Russia pills
Aertal (Gedeon Richter Gedeon Richter Hungary cream
Aertal Almiral S.A Spain pills
Aertal (Almiral S.A Almiral S.A Spain tea bags

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Dosage and Administration

pills for oral use. Depending on the disease and the age of the patient, it is prescribed from 100 to 200 mg of the drug per day. At 100 mg at a time, whole, without dividing and chewing, drinking plenty of liquid.

Topically. The substance in the composition of the ointment or cream with a thin layer is carefully applied to the area of ​​inflammation 3 times a day. After using the drug, it is recommended to wash your hands thoroughly with soap and not to let the product get into your eyes.

Adverse reactions

During treatment with Aceclofenac, there are often:

  • dizziness, nausea, abnormalities in the gastrointestinal tract, abdominal pain, indigestion, diarrhea;
  • increased activity of liver enzymes, allergic reactions in the form of skin rash and itching.

Rarely develop:

  • anemia, anaphylactic reactions, reduced visual acuity;
  • high blood pressure, heart failure, shortness of breath;
  • increased concentration of creatinine and urea in the blood;
  • constipation, ulcers in the oral cavity, increased flatulence, gastritis, vomiting;
  • stomach ulcer, melena, hemorrhoids;
  • dermatitis, itching, angioedema, urticaria.

Very rarely occur:

  • muscle cramps, weakness and fatigue, weight gain, hyperkalemia, eczema;
  • renal failure, nephrotic syndrome, nephritis;
  • purpura, Stevens-Johnson syndrome, soft tissue infections with chickenpox, toxic epidermal necrolysis;
  • granulocytopenia, neutropenia, impaired blood formation, thrombocytopenia, hemolytic anemia;
  • depression, vivid dreams and nightmares, sleep disturbances, vertigo, vasculitis;
  • tremor, perversion of taste, drowsiness, paresthesias, tinnitus;
  • perforation of the intestine, pancreatitis, ulcerative colitis, vomiting with blood;
  • hyperemia of the skin, hot flashes, tachycardia;
  • bronchospasm, stomatitis, hepatitis.


The drug is contraindicated:

  • with allergies to the active substance;
  • patients with ulcers and erosions in the gastrointestinal tract, during exacerbation;
  • with Crohn's disease and ulcerative colitis;
  • if there is a suspicion of bleeding from the gastrointestinal tract;
  • with severe liver disease and liver failure;
  • pregnant women;
  • patients with disorders of blood formation or bleeding disorders;
  • during breastfeeding;
  • renal failure, hyperkalemia, progressive kidney disease;
  • children under 18;
  • during the recovery period after coronary artery bypass surgery;
  • with the “aspirin triad”;
  • persons suffering from severe heart failure.

Caution should be observed:

  • with diseases of the kidneys, gastrointestinal tract and liver moderate and mild severity;
  • if the patient has a Helicobacter bacterium in the gastrointestinal tract;
  • with bronchial asthma;
  • persons with low blood pressure;
  • after extensive surgery, if the volume of circulating blood is reduced;
  • with ischemia;
  • elderly people;
  • patients with cerebrovascular diseases;
  • diabetes;
  • after long-term treatment with NSAIDs;
  • alcoholics and smoking people;
  • with severe somatic diseases;
  • patients with defects of hemostasis;
  • with systemic lupus erythematosus;
  • in combination with anticoagulants, serotonin reuptake inhibitors, antiplatelet agents.

Ointment or cream should not be applied to damaged skin.

Drug interactions

Anticoagulants when combined with pills increase the risk of bleeding. During treatment, it is recommended to periodically monitor blood clotting.

Aceclofenac pills increase the plasma concentration of digoxin, phenytoin, lithium-based drugs.

The substance when combined with antihypertensive drugs and diuretics reduces the effectiveness of the latter.

The combination of the drug with potassium-sparing diuretics increases the likelihood of hyperkalemia.

With caution should combine the drug with NSAIDs and glucocorticosteroids, the tool increases the toxicity of methotrexate and cyclosporine.

Aspirin reduces the plasma concentration of aceclofenac.

The combination of drugs with hypoglycemic drugs requires constant monitoring of blood glucose levels.

Pregnancy and Lactation

Absolute contraindication to the use of funds is the 3rd trimester of pregnancy.

In the first and second trimesters and during breastfeeding, special care must be taken. The medicine may be prescribed by a doctor when urgently needed.

Special instructions

As a precautionary measure during treatment with the drug is recommended to use the minimum effective and active dosage. It also shows periodic monitoring of the liver and kidneys, a picture of peripheral blood, feces (lack of blood), and the cardiovascular system.

During treatment, you can not drive a car or perform potentially hazardous activities.

The risk of allergies or skin reactions is higher in the first months of taking the medicine. If there is damage to the mucous membrane of the mouth, skin rash, other signs of allergy, then therapy should be interrupted.

The process of inhibition of platelets during treatment with a drug is reversible, the composition of the blood normalizes some time after the drug is withdrawn.


There are no cases of drug overdose in humans.

Symptoms of an overdose are: headaches, cramps, vomiting, abdominal pain, nausea, dizziness. As therapy, enterosorbents are used, the stomach is washed, symptomatic treatment is performed. The drug has no specific antidote, hemodialysis and forced diuresis are ineffective.

  • Brand name: Aceclofenac
  • Active ingredient: Aceclofenac
  • Manufacturer: Synthesis AKOMP

Studies and clinical trials of Aceclofenac (Click to expand)

  1. Bioequivalence evaluation of two brands of aceclofenac 100mg tablets (Aceclofar and Bristaflam) in healthy human volunteers
  2. Simultaneous determination of aceclofenac and three of its metabolites in human plasma by high-performance liquid chromatography
  3. Trials of clear aceclofenac-loaded soft capsules with accelerated oral absorption in human subjects
  4. Enhancement of dissolution rate and bioavailability of aceclofenac: A chitosan-based solvent change approach
  5. High-performance liquid chromatography and pharmacokinetics of aceclofenac in rats
  6. Simultaneous HPLC–UV determination of rhein and aceclofenac in human plasma
  7. Polarographic behaviour of Aceclofenac, Tenoxicam and Droxicam in a methanol–water mixture
  8. Simultaneous determination of aceclofenac and its three metabolites in plasma using liquid chromatography–tandem mass spectrometry
  9. Improvement of dissolution rate of aceclofenac by solid dispersion technique
  10. Aceclofenac spares cyclooxygenase 1 as a result of limited but sustained biotransformation to diclofenac
  11. Simultaneous determination of aceclofenac and diclofenac in human plasma by narrowbore HPLC using column-switching
  12. Determination of aceclofenac in bulk and pharmaceutical formulations
  13. Spectrophotometric and spectrofluorimetric determination of etodolac and aceclofenac
  14. Photoallergic contact dermatitis from aceclofenac
  15. The efficacy and tolerability of aceclofenac compared to indomethacin in patients with rheumatoid arthritis
  16. Aceclofenac in comparison to ketoprofen in the treatment of rheumatoid arthritis
  17. Crystal structure and spectroscopic study of 2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid (Aceclofenac)
  18. Comparison of aceclofenac with diclofenac in the treatment of osteoarthritis
  19. Comparative study of the efficacy and safety of Aceclofenac and Tenoxicam in rheumatoid arthritis
  20. Aceclofenac in rheumatoid arthritis: A useful and novel anti-inflammatory
  21. Aceclofenac is a well-tolerated alternative to naproxen in the treatment of osteoarthritis
  22. Comparison of aceclofenac with piroxicam in the treatment of osteoarthritis
  23. Preparation and evaluation of aceclofenac microemulsion for transdermal delivery system
  24. Formulation of microemulsion systems for transdermal delivery of aceclofenac

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