

Aceclofenac is a nonsteroidal anti-inflammatory agent derived from phenylacetic acid. Aceclofenac has analgesic, anti-inflammatory, antipyretic effects, which are associated with inhibition of cyclooxygenase 1 and 2, which regulate the production of prostaglandins. When taken inside, aceclofenac is well absorbed. The maximum concentration is reached in 1.25 - 3 hours. Aceclofenac enters the articular fluid, where its content reaches 57% of plasma concentrations, and the time maximum concentration is reached 2 to 4 hours longer than in plasma. The volume of distribution of aceclofenac is 25 liters. Plasma proteins (albumin) aceclofenac is 99% bound. Aceclofenac circulates mainly unchanged, its main metabolite is 4'-hydroxyaceclofenac. the half-life is 4 hours. Aceclofenac excreted by the kidneys, more than 60% in the form of hydroxy derivatives.
The drug is prescribed:
The use of Aceclofenac is not able to completely cure these diseases, however, it quickly reduces inflammation and pain.
Active substances:
Aceclofenac - 100 mg
Excipients:
Core Composition:
Calcium stearate - 3 mg
Talc - 9 mg
Colloidal silicon dioxide (Aerosil) - 1.5 mg
Microcrystalline cellulose - 85 mg
Croscarmellose sodium (primelloza) - 10.5 mg
Lactose monohydrate (milk sugar) - 91 mg
Kernel mass - 300 mg
Shell composition:
Hypromellose (hydroxypropylmethylcellulose) - 6.4 mg
Macrogol - 4000 (polyethylene oxide-4000) - 2.5 mg
Titanium dioxide (titanium dioxide) - 1.1 mg
Tablet weight - 310 mg
Aceclofenac is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Aceclofenac | pills | ||
Alental | Vertex | Russia | pills |
Aertal (Gedeon Richter | Gedeon Richter | Hungary | cream |
Aertal | Almiral S.A | Spain | pills |
Aertal (Almiral S.A | Almiral S.A | Spain | tea bags |
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pills for oral use. Depending on the disease and the age of the patient, it is prescribed from 100 to 200 mg of the drug per day. At 100 mg at a time, whole, without dividing and chewing, drinking plenty of liquid.
Topically. The substance in the composition of the ointment or cream with a thin layer is carefully applied to the area of inflammation 3 times a day. After using the drug, it is recommended to wash your hands thoroughly with soap and not to let the product get into your eyes.
During treatment with Aceclofenac, there are often:
Rarely develop:
Very rarely occur:
The drug is contraindicated:
Caution should be observed:
Ointment or cream should not be applied to damaged skin.
Anticoagulants when combined with pills increase the risk of bleeding. During treatment, it is recommended to periodically monitor blood clotting.
Aceclofenac pills increase the plasma concentration of digoxin, phenytoin, lithium-based drugs.
The substance when combined with antihypertensive drugs and diuretics reduces the effectiveness of the latter.
The combination of the drug with potassium-sparing diuretics increases the likelihood of hyperkalemia.
With caution should combine the drug with NSAIDs and glucocorticosteroids, the tool increases the toxicity of methotrexate and cyclosporine.
Aspirin reduces the plasma concentration of aceclofenac.
The combination of drugs with hypoglycemic drugs requires constant monitoring of blood glucose levels.
Absolute contraindication to the use of funds is the 3rd trimester of pregnancy.
In the first and second trimesters and during breastfeeding, special care must be taken. The medicine may be prescribed by a doctor when urgently needed.
As a precautionary measure during treatment with the drug is recommended to use the minimum effective and active dosage. It also shows periodic monitoring of the liver and kidneys, a picture of peripheral blood, feces (lack of blood), and the cardiovascular system.
During treatment, you can not drive a car or perform potentially hazardous activities.
The risk of allergies or skin reactions is higher in the first months of taking the medicine. If there is damage to the mucous membrane of the mouth, skin rash, other signs of allergy, then therapy should be interrupted.
The process of inhibition of platelets during treatment with a drug is reversible, the composition of the blood normalizes some time after the drug is withdrawn.
There are no cases of drug overdose in humans.
Symptoms of an overdose are: headaches, cramps, vomiting, abdominal pain, nausea, dizziness. As therapy, enterosorbents are used, the stomach is washed, symptomatic treatment is performed. The drug has no specific antidote, hemodialysis and forced diuresis are ineffective.
Studies and clinical trials of Aceclofenac (Click to expand)