

Acyclovir is an antiviral drug, a synthetic analogue of the acyclic purine nucleoside, which has a highly selective effect on herpes viruses. Inside viral infected cells, viral thymidine kinase undergoes a series of consecutive transformations of acyclovir into mono-, di-, and acyclovir triphosphate. Acyclovir triphosphate is inserted into the viral DNA chain and blocks its synthesis through competitive inhibition of viral DNA polymerase. In vitro acyclovir active against Herpes simplex type 1 and 2, Varicella zoster; higher concentrations are required to inhibit Epstein-Barr virus. In vivo acyclovir is therapeutically and prophylactically effective primarily for viral infections caused by Herpes simplex.
- treatment of infections of the skin and mucous membranes caused by Herpes simplex type 1 and 2, both primary and secondary, including genital herpes;
- prevention of exacerbations of recurrent infections caused by the virus Herpes simplex type 1 and 2 in patients with normal immune status;
- prevention of primary and recurrent infections caused by the Herpes simplex type 1 and 2 virus in patients with immunodeficiency;
- as part of complex therapy in patients with severe immunodeficiency: in HIV infection (AIDS stage, early clinical manifestations and detailed clinical picture) and in patients undergoing bone marrow transplantation;
- treatment of primary and recurrent infections caused by the virus Varicella zoster (chickenpox, shingles).
1 g of ointment contains acyclovir 50 mg.
Acyclovir is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Acyclovir-Akrikhin (Akrikhin | Akrikhin | Russia | ointment |
Acyclovir | Vertex | Russia | cream |
Acyclovir | Sandoz | Switzerland | cream |
Acyclovir | Synthesis | Russia | ointment |
Acyclovir | Belmedpreparaty | Belarus | pills |
Acyclovir | Sandoz | Switzerland | pills |
Acyclovir | Obolensky OP | Russia | pills |
Acyclovir | Belmedpreparaty | Belarus | ointment |
Acyclovir | Belupo | Croatia | cream |
Acyclovir | Ozon | Russia | ointment |
Acyclovir-Akos | Synthesis AKOMP | Russia | pills |
Acyclovir | Belupo | Croatia | pills |
Zovirax pills | GlaxoSmithKline | Spain/Poland | pills |
Zovirax | GlaxoSmithKline | UK | vials |
Acyclovir-Akrikhin | Akrikhin | Russia | pills |
Gerperax ointment | Micro Labs Ltd | India | ointment |
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Ointment Acyclovir is applied to the affected surface 5 times / day (after 4 hours). The duration of treatment is 5-10 days.
From the digestive system: in rare cases - abdominal pain, nausea, vomiting, diarrhea; rarely, a transient increase in liver enzyme activity, hyperbilirubinemia.
From the hemopoietic system: rarely - leukopenia, erythropenia.
From the side of the central nervous system: rarely - headache, weakness; in some cases - tremor, dizziness, fatigue, drowsiness, hallucinations.
Allergic reactions: skin rash; rarely - allergic dermatitis (when applying the ointment).
Local reactions: When applying the ointment, it is possible - redness, itching, peeling, burning or stinging.
Other: rarely - alopecia, fever, increased levels of urea and creatinine.
- hypersensitivity to acyclovir, ganciclovir or drug components;
- lactation period (breastfeeding).
WITH caution the drug should be prescribed for dehydration, renal failure, neurological disorders, including in the anamnesis.
The ointment is not recommended to be applied on the mucous membranes of the oral cavity, eyes, genitals, because may develop severe local inflammation.
The effectiveness of treatment when applying the ointment will be the higher, the earlier it is started.
Studies and clinical trials of Acyclovir (Click to expand)