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Acyclovir is an antiviral drug, a synthetic analogue of the acyclic purine nucleoside, which has a highly selective effect on herpes viruses. Inside viral infected cells, viral thymidine kinase undergoes a series of consecutive transformations of acyclovir into mono-, di-, and acyclovir triphosphate. Acyclovir triphosphate is inserted into the viral DNA chain and blocks its synthesis through competitive inhibition of viral DNA polymerase. In vitro acyclovir active against Herpes simplex type 1 and 2, Varicella zoster; higher concentrations are required to inhibit Epstein-Barr virus. In vivo acyclovir is therapeutically and prophylactically effective primarily for viral infections caused by Herpes simplex.
- treatment of infections of the skin and mucous membranes caused by Herpes simplex type 1 and 2, both primary and secondary, including genital herpes;
- prevention of exacerbations of recurrent infections caused by the virus Herpes simplex type 1 and 2 in patients with normal immune status;
- prevention of primary and recurrent infections caused by the Herpes simplex type 1 and 2 virus in patients with immunodeficiency;
- as part of complex therapy in patients with severe immunodeficiency: in HIV infection (AIDS stage, early clinical manifestations and detailed clinical picture) and in patients undergoing bone marrow transplantation;
- treatment of primary and recurrent infections caused by the virus Varicella zoster (chickenpox, shingles).
1 g of ointment contains acyclovir 50 mg.
Acyclovir is marketed under different brands and generic names, and comes in different dosage forms:
|Brand name||Manufacturer||Country||Dosage form|
|Gerperax ointment||Micro Labs Ltd||India||ointment|
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Dosage and Administration
Ointment Acyclovir is applied to the affected surface 5 times / day (after 4 hours). The duration of treatment is 5-10 days.
From the digestive system: in rare cases - abdominal pain, nausea, vomiting, diarrhea; rarely, a transient increase in liver enzyme activity, hyperbilirubinemia.
From the hemopoietic system: rarely - leukopenia, erythropenia.
From the side of the central nervous system: rarely - headache, weakness; in some cases - tremor, dizziness, fatigue, drowsiness, hallucinations.
Allergic reactions: skin rash; rarely - allergic dermatitis (when applying the ointment).
Local reactions: When applying the ointment, it is possible - redness, itching, peeling, burning or stinging.
Other: rarely - alopecia, fever, increased levels of urea and creatinine.
- hypersensitivity to acyclovir, ganciclovir or drug components;
- lactation period (breastfeeding).
WITH caution the drug should be prescribed for dehydration, renal failure, neurological disorders, including in the anamnesis.
The ointment is not recommended to be applied on the mucous membranes of the oral cavity, eyes, genitals, because may develop severe local inflammation.
The effectiveness of treatment when applying the ointment will be the higher, the earlier it is started.
- Brand name: Acyclovir-Akrikhin
- Active ingredient: Acyclovir
- Dosage form: Ointment for external use.
- Manufacturer: Akrikhin
- Country of Origin: Russia
- Effect of acyclovir and prednisolone on the serological response in herpes zoster
- Acyclovir-resistant Varicella-Zoster virus: Phenotypic and genetic characterization
- Nucleotide sequence of thymidine kinase gene of sequential acyclovir-resistant herpes simplex virus type 1 isolates recovered from a child with Wiskott-Aldrich syndrome: Evidence for reactivation of acyclovir-resistant herpes simplex virus
- NMR spectral data for acyclovir prodrugs
- Comparison of High Performance Capillary Electrophoresis and Liquid Chromatography for the Determination of Acyclovir and Guanine in Pharmaceuticals and Urine
- Fluorimetric study of acyclovir in acidic micellar media
- Carrier-mediated intestinal absorption of valacyclovir, the L-valyl ester prodrug of acyclovir. 1. Interactions with peptides, organic anions and organic cations in rats
- Safety of Acyclovir in General Practice: A Review of the Literature
- Utilization and Safety of Oral Acyclovir over an 8-Year Period
- All Patients with Recurrent Genital Herpes Should be Offered Suppressive Therapy with Acyclovir
- All Patients with Recurrent Genital Herpes Should not be Offered Suppressive Therapy with Acyclovir
- Unusual Tritylation Reactions of Tricyclic Analogues of Acyclovir and an Attempt to Elucidate Their Mechanism
- In vitro effects of a combination of zldovudine and acyclovir on growth of normal human myelold progenitor cells
- Reactivation of acyclovir-resistant thymidine kinase-deficient herpes simplex virus harbouring single base insertion within a 7 Gs homopolymer repeat of the thymidine kinase gene
- Susceptibility to acyclovir of herpes simplex virus isolates obtained between 1977 and 1996 in Japan
- Synthesis and Structural Characterisation of a New Form of Bis(acyclovir)(ethylenediamine)platinum(II) − Correlation between the Puckering of the Carrier Ligand and the Canting of the Nucleobases
- Synthesis, Characterisation and Antiviral Activity of Platinum(II) Complexes with 1,10-Phenanthrolines and the Antiviral Agents Acyclovir and Penciclovir
- Novel RuIII-DMSO Complexes of the Antiherpes Drug Acyclovir
- Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir
- Chemical stability, enzymatic hydrolysis, and nasal uptake of amino acid ester prodrugs of acyclovir
- Analysis of acyclovir by high performance capillary electrophoresis with on-column amperometric detection
- Long-term ultra-low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation
- Acyclovir in the treatment of aplastic anemia
- Acyclovir as treatment for aplastic anemia