Acyclovir

Brand Akrikhin

In stock 719 Items

Available since: 2019-09-19

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Clinical Pharmacology

Acyclovir is an antiviral drug, a synthetic analogue of the acyclic purine nucleoside, which has a highly selective effect on herpes viruses. Inside viral infected cells, viral thymidine kinase undergoes a series of consecutive transformations of acyclovir into mono-, di-, and acyclovir triphosphate. Acyclovir triphosphate is inserted into the viral DNA chain and blocks its synthesis through competitive inhibition of viral DNA polymerase. In vitro acyclovir active against Herpes simplex type 1 and 2, Varicella zoster; higher concentrations are required to inhibit Epstein-Barr virus. In vivo acyclovir is therapeutically and prophylactically effective primarily for viral infections caused by Herpes simplex.

Indications

- treatment of infections of the skin and mucous membranes caused by Herpes simplex type 1 and 2, both primary and secondary, including genital herpes;
- prevention of exacerbations of recurrent infections caused by the virus Herpes simplex type 1 and 2 in patients with normal immune status;
- prevention of primary and recurrent infections caused by the Herpes simplex type 1 and 2 virus in patients with immunodeficiency;
- as part of complex therapy in patients with severe immunodeficiency: in HIV infection (AIDS stage, early clinical manifestations and detailed clinical picture) and in patients undergoing bone marrow transplantation;
- treatment of primary and recurrent infections caused by the virus Varicella zoster (chickenpox, shingles).

Composition

1 g of ointment contains acyclovir 50 mg.

Acyclovir is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Acyclovir-Akrikhin (Akrikhin	Akrikhin	Russia	ointment
Acyclovir	Vertex	Russia	cream
Acyclovir	Sandoz	Switzerland	cream
Acyclovir	Synthesis	Russia	ointment
Acyclovir	Belmedpreparaty	Belarus	pills
Acyclovir	Sandoz	Switzerland	pills
Acyclovir	Obolensky OP	Russia	pills
Acyclovir	Belmedpreparaty	Belarus	ointment
Acyclovir	Belupo	Croatia	cream
Acyclovir	Ozon	Russia	ointment
Acyclovir-Akos	Synthesis AKOMP	Russia	pills
Acyclovir	Belupo	Croatia	pills
Zovirax pills	GlaxoSmithKline	Spain/Poland	pills
Zovirax	GlaxoSmithKline	UK	vials
Acyclovir-Akrikhin	Akrikhin	Russia	pills
Gerperax ointment	Micro Labs Ltd	India	ointment

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Dosage and Administration

Ointment Acyclovir is applied to the affected surface 5 times / day (after 4 hours). The duration of treatment is 5-10 days.

Adverse reactions

From the digestive system: in rare cases - abdominal pain, nausea, vomiting, diarrhea; rarely, a transient increase in liver enzyme activity, hyperbilirubinemia.
From the hemopoietic system: rarely - leukopenia, erythropenia.
From the side of the central nervous system: rarely - headache, weakness; in some cases - tremor, dizziness, fatigue, drowsiness, hallucinations.
Allergic reactions: skin rash; rarely - allergic dermatitis (when applying the ointment).
Local reactions: When applying the ointment, it is possible - redness, itching, peeling, burning or stinging.
Other: rarely - alopecia, fever, increased levels of urea and creatinine.

Contraindications

- hypersensitivity to acyclovir, ganciclovir or drug components;
- lactation period (breastfeeding).
WITH caution the drug should be prescribed for dehydration, renal failure, neurological disorders, including in the anamnesis.

Special instructions

The ointment is not recommended to be applied on the mucous membranes of the oral cavity, eyes, genitals, because may develop severe local inflammation.
The effectiveness of treatment when applying the ointment will be the higher, the earlier it is started.