Adapalene
Ranbaxy Laboratories Ltd
1738 Items
2019-09-19
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Clinical Pharmacology
Adaklin - a drug for external use. Adapalen is a metabolite of the retinoid, has comedoliticheskoe and anti-inflammatory action, normalizes the process of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific gamma receptors of epidermal skin cells.
As a result of the action of adapalene, in particular, there is a decrease in the “cohesion” of epithelial cells in the mouth of the hair-tissue follicle and a decrease in the prerequisites for the formation of microcomedo. Adapalen has anti-inflammatory effects in vitro and in vivo, affecting inflammation factors by inhibiting leukocyte migration in the focus of inflammation and arachidonic acid metabolism.
Absorption: adapalene absorption through the skin is very low (about 4% of the applied dose). Excretion: removal of adapalena from the body occurs mainly with bile.
Indications
Acne.
Composition
active substance: adapalene 1 mg.
Excipients: Methyl dextroses stearate 35 mg, macrogol (20) 35 mg, squalane (natural) 60 mg, methyl parahydroxybenzoate 2 mg, propyl parahydroxybenzoate 1 mg, disodium edetate 1 mg, phenoxyethanol 5 mg, glycerol 30 mg, carbomer (934P) 4 mg, 4 mg, phenoxyethanol, 5 mg, glycerol 30 mg, carbomer (934P) 4 mg, 4 mg, phenoxyethanol, 5 mg, glycerol, 30 mg, carbomer (934P), 4 mg, 4 mg, phenoxyethanol, 4% glycerol, carbomer (934P), 4 mg, 4 mg, phenoxyethanol, glycerol, 29%. mg, sodium hydroxide 0.5 mg.
Adapalene is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Adaclin | Ranbaxy Laboratories Ltd | India | cream |
| Klenzit-C (Glenmark | Glenmark | India | gel |
| Klenzit | Glenmark | India | gel |
| Differin | Laboratories Galderma | France | cream |
| Differin | Laboratories Galderma | France | gel |
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Dosage and Administration
Topically. Before applying the cream must be cleaned and dried skin. With a light touch, apply the cream evenly on the affected surface 1 time a day before going to bed, avoiding getting the drug on the mucous membranes of the eyes and lips. The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment. In some cases, due to short-term irritation of the skin, treatment may be suspended until the signs of irritation disappear. A second course of treatment is possible after consulting a doctor.
Adverse reactions
Dermatological reactions: skin irritation, hyperemia and peeling of the skin at the site of application (treatment should be stopped until the skin irritation disappears or the frequency of application is reduced).
Contraindications
With care: the drug should be used with caution in dermatitis, eczema, seborrhea.
Drug interactions
Since adapalen does not interact with oxygen and is not destroyed by light, it is possible to simultaneously treat acne with drugs such as clindamycin or benzoyl peroxide.
Pregnancy and Lactation
It is not recommended to use the drug during pregnancy and lactation (breastfeeding).
Special instructions
In case of accidental contact with the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water. Direct sunlight should be avoided as skin irritation may occur. Treatment can be continued if sun exposure is minimized through the use of sunglasses and hats.
The simultaneous use of cosmetics with a drying and irritating effect on the skin (for example, perfume or ethanol-containing products) is not recommended. Adapalen applied to the skin in the evening can be combined with preparations for the treatment of acne, applied in the morning.
Overdosage
An overdose of the drug is unlikely.
- Brand name: Adaklin
- Active ingredient: Adapalen
- Dosage form: Cream for external use
- Manufacturer: Ranbaxy Laboratories Ltd
- Country of Origin: India
Studies and clinical trials of Adapalene (Click to expand)
- The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro
- Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne
- Pivotal clinical trials of adapalene in the treatment of acne
- An update of recent clinical trials examining adapalene and acne
- A comparison of adapalene gel 0.1% vs. tretinoin gel 0.025% in the treatment of acne vulgaris in China
- Adapalene in the treatment of African patients
- Pharmacology of adapalene
- Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation
- Adapalene 0·1% gel and adapalene 0·1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers
- Adapalene 0·1% gel for the treatment of acne vulgaris: its superiority compared to tretinoin 0·025% cream in skin tolerance and patient preference
- Adapalene 0·1% gel has low skin irritation potential even when applied immediately after washing
- Evaluation of clinical efficacy and safety of adapalene 0·1% gel versus tretinoin 0·025% gel in the treatment of acne vulgaris, with particular reference to the onset of action and impact on quality of life
- Comparative tolerance of adapalene 0·1% gel and six different tretinoin formulations
- Comparison of adapalene 0·1% solution and tretinoin 0·025% gel in the topical treatment of acne vulgaris
- A comparison of the efficacy and tolerability of adapalene 0·1% gel versus tretinoin 0·025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials
- Topical adapalene gel 0·1% vs. isotretinoin gel 0·05% in the treatment of acne vulgaris: a randomized open-label clinical trial
- Adapalene: an update on newer comparative studies between the various retinoids
- Perioral dermatitis successfully treated with topical adapalene
- Determination of adapalene (CD271/differin®) and retinol in plasma and tissue by on-line solid-phase extraction and HPLC analysis
- Comparison of CD271 (Adapalene) and All-Trans Retinoic Acid in Human Skin: Dissociation of Epidermal Effects and CRABP-II mRNA Expression.
- FS03.5 Evaluation of the irritancy potential of adapalene and tretinoin in volunteers of different ethnic origins
- Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: A randomized study
- Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator-masked, controlled trial
- A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris
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