Buy Adaclin cream 1 mg/g, 30 g
  • Buy Adaclin cream 1 mg/g, 30 g

Adapalene

Ranbaxy Laboratories Ltd
1738 Items
2019-09-19
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$31.15
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Clinical Pharmacology

Adaklin - a drug for external use. Adapalen is a metabolite of the retinoid, has comedoliticheskoe and anti-inflammatory action, normalizes the process of keratinization and epidermal differentiation. The mechanism of action of adapalene is based on interaction with specific gamma receptors of epidermal skin cells.

As a result of the action of adapalene, in particular, there is a decrease in the “cohesion” of epithelial cells in the mouth of the hair-tissue follicle and a decrease in the prerequisites for the formation of microcomedo. Adapalen has anti-inflammatory effects in vitro and in vivo, affecting inflammation factors by inhibiting leukocyte migration in the focus of inflammation and arachidonic acid metabolism.

Absorption: adapalene absorption through the skin is very low (about 4% of the applied dose). Excretion: removal of adapalena from the body occurs mainly with bile.

Indications

Acne.

Composition

active substance: adapalene 1 mg.

Excipients: Methyl dextroses stearate 35 mg, macrogol (20) 35 mg, squalane (natural) 60 mg, methyl parahydroxybenzoate 2 mg, propyl parahydroxybenzoate 1 mg, disodium edetate 1 mg, phenoxyethanol 5 mg, glycerol 30 mg, carbomer (934P) 4 mg, 4 mg, phenoxyethanol, 5 mg, glycerol 30 mg, carbomer (934P) 4 mg, 4 mg, phenoxyethanol, 5 mg, glycerol, 30 mg, carbomer (934P), 4 mg, 4 mg, phenoxyethanol, 4% glycerol, carbomer (934P), 4 mg, 4 mg, phenoxyethanol, glycerol, 29%. mg, sodium hydroxide 0.5 mg.

Adapalene is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Adaclin Ranbaxy Laboratories Ltd India cream
Klenzit-C (Glenmark Glenmark India gel
Klenzit Glenmark India gel
Differin Laboratories Galderma France cream
Differin Laboratories Galderma France gel

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Adapalene

Dosage and Administration

Topically. Before applying the cream must be cleaned and dried skin. With a light touch, apply the cream evenly on the affected surface 1 time a day before going to bed, avoiding getting the drug on the mucous membranes of the eyes and lips. The therapeutic effect develops after 4-8 weeks of treatment, persistent improvement occurs after 3 months of treatment. In some cases, due to short-term irritation of the skin, treatment may be suspended until the signs of irritation disappear. A second course of treatment is possible after consulting a doctor.

Adverse reactions

Dermatological reactions: skin irritation, hyperemia and peeling of the skin at the site of application (treatment should be stopped until the skin irritation disappears or the frequency of application is reduced).

Contraindications

With care: the drug should be used with caution in dermatitis, eczema, seborrhea.

Drug interactions

Since adapalen does not interact with oxygen and is not destroyed by light, it is possible to simultaneously treat acne with drugs such as clindamycin or benzoyl peroxide.

Pregnancy and Lactation

It is not recommended to use the drug during pregnancy and lactation (breastfeeding).

Special instructions

In case of accidental contact with the mucous membranes of the eyes, mouth or nose, rinse thoroughly with warm water. Direct sunlight should be avoided as skin irritation may occur. Treatment can be continued if sun exposure is minimized through the use of sunglasses and hats.

The simultaneous use of cosmetics with a drying and irritating effect on the skin (for example, perfume or ethanol-containing products) is not recommended. Adapalen applied to the skin in the evening can be combined with preparations for the treatment of acne, applied in the morning.

Overdosage

An overdose of the drug is unlikely.

  • Brand name: Adaklin
  • Active ingredient: Adapalen
  • Dosage form: Cream for external use
  • Manufacturer: Ranbaxy Laboratories Ltd
  • Country of Origin: India

Studies and clinical trials of Adapalene (Click to expand)

  1. The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro
  2. Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne
  3. Pivotal clinical trials of adapalene in the treatment of acne
  4. An update of recent clinical trials examining adapalene and acne
  5. A comparison of adapalene gel 0.1% vs. tretinoin gel 0.025% in the treatment of acne vulgaris in China
  6. Adapalene in the treatment of African patients
  7. Pharmacology of adapalene
  8. Chemical stability of adapalene and tretinoin when combined with benzoyl peroxide in presence and in absence of visible light and ultraviolet radiation
  9. Adapalene 0·1% gel and adapalene 0·1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers
  10. Adapalene 0·1% gel for the treatment of acne vulgaris: its superiority compared to tretinoin 0·025% cream in skin tolerance and patient preference
  11. Adapalene 0·1% gel has low skin irritation potential even when applied immediately after washing
  12. Evaluation of clinical efficacy and safety of adapalene 0·1% gel versus tretinoin 0·025% gel in the treatment of acne vulgaris, with particular reference to the onset of action and impact on quality of life
  13. Comparative tolerance of adapalene 0·1% gel and six different tretinoin formulations
  14. Comparison of adapalene 0·1% solution and tretinoin 0·025% gel in the topical treatment of acne vulgaris
  15. A comparison of the efficacy and tolerability of adapalene 0·1% gel versus tretinoin 0·025% gel in patients with acne vulgaris: a meta-analysis of five randomized trials
  16. Topical adapalene gel 0·1% vs. isotretinoin gel 0·05% in the treatment of acne vulgaris: a randomized open-label clinical trial
  17. Adapalene: an update on newer comparative studies between the various retinoids
  18. Perioral dermatitis successfully treated with topical adapalene
  19. Determination of adapalene (CD271/differin®) and retinol in plasma and tissue by on-line solid-phase extraction and HPLC analysis
  20. Comparison of CD271 (Adapalene) and All-Trans Retinoic Acid in Human Skin: Dissociation of Epidermal Effects and CRABP-II mRNA Expression.
  21. FS03.5 Evaluation of the irritancy potential of adapalene and tretinoin in volunteers of different ethnic origins
  22. Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: A randomized study
  23. Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator-masked, controlled trial
  24. A randomized, single-blind comparison of topical clindamycin + benzoyl peroxide and adapalene in the treatment of mild to moderate facial acne vulgaris

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