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Geptral is a medication that is used to treat liver disorders and depression. Several studies also suggests that the drug can be used to treat other mental disorders as well. The active ingredient of Geptral is S-Adenosylmethionine (Ademetionine).
Ademetionine is the methyl donor to numerous and diverse acceptor molecules including DNA, proteins, phospholipids and catechol- and indoleamines.
The therapeutic effect of Geptral in some depressive illnesses has led to new nontoxic treatment strategies. There have been encouraging pilot studies of the use of Ademetionine in patients with Parkinson’s disease, epilepsy and Alzheimer’s dementia. Furthermore, impaired C-I metabolism and Heptral synthesis has been proposed to be a common pathogenic mechanism in Alzheimer’s dementia, Down’s syndrome and HIV infection, thus lending further support for clinical trials with methyl donors in these conditions.
Convincing evidence from studies of inborn errors of methyl group metabolism have shown that methylation is important in maintaining the integrity of the myelin sheath. Correction of the methyl group deficiency with methyl group donors, including oral Ademetionine treatment, can halt or even reverse the demyelination process. Heptral appears to influence monoamine neurotransmitter metabolism and receptors, which may be the putative mechanism of action in the treatment of depression.
Clinical trials to date with Heptral have shown it to be a relatively safe compound, with no serious adverse reactions observed, and it is devoid of any hepatotoxic effects. This is probably related to the fact that it is a natural ubiquitous metabolite present in all organisms. The full clinical potential of Ademetionine in some neurological disorders remains to be explored.
Indications for use are:
- Alcohol related liver disease
- Intrahepatic cholestasis
Adiarin® is marketed under different brands and generic names, and comes in different dosage forms:
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Dosage and Administration
According to instructions.
Individual intolerance to the components of dietary supplements.
- Brand name: Adiarin Rehydro
- Active ingredient: Specialized complex of mineral salts and glucose
- Manufacturer: Agio Pharmaceuticals Ltd