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Non-fluorinated synthetic GCS for external use. It has anti-inflammatory, anti-allergic, antipruritic and anti-proliferative effects.
When applied to the skin surface in the focus of inflammation, it quickly and effectively reduces the severity of objective symptoms (erythema, edema, lichenification) and subjective sensations (itching, irritation, pain).
Dermatoses, in which topical therapy of GCS is effective (including with localization on the skin of the face and in the anogenital area):
- atopic dermatitis;
- allergic and contact dermatitis;
- solar dermatitis;
- allergic reactions to insect bites.
The drug can be used in children from 6 months.
1 g ointment contains:
Active ingredient: alklomethasone dipropionate - 0.5 mg.
Excipients: soft white paraffin - 799.5 mg; white beeswax - 60 mg; propylene glycol monopalmitostearate - 20 mg; hexylene glycol - 120 mg.
Alclomethasone is marketed under different brands and generic names, and comes in different dosage forms:
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Dosage and Administration
The ointment is recommended for the treatment of sub-acute and chronic dermatoses, incl. dry, lichenized and flaky lesions, or in cases where an occlusive ointment effect is necessary.
Ointment evenly applied with a thin layer on the affected skin 2-3 times / day. On areas with denser skin (for example, elbows, palms and feet), as well as places where the drug is easily erased, Afloderm should be applied more often.
In children and in the period of subsiding the main symptoms of the drug can be used 1 time / day.
For the prevention of recurrence in the treatment of chronic diseases, therapy should continue for some time after the disappearance of all symptoms.
Usually the drug is well tolerated. Side effects from external use of alclomethasone rarely develop and are reversible.
On the part of the skin: with a frequency of 1% (for ointment) and 2% (for cream) - itching, burning, erythema; with a frequency of 2% (for cream) in addition - dry skin, irritation, papular rash; common for both dosage forms: infrequently - folliculitis, acneform rash, hypopigmentation, perioral dermatitis, dermatitis, secondary infection, skin atrophy, stretch marks, prickly heat.
In the case of the development of hypersensitivity reactions or side effects, therapy should be canceled and consult a doctor.
- skin tuberculosis;
- skin manifestations of syphilis;
- viral infections of the skin;
- skin post-vaccination reactions;
- open wounds;
- trophic ulcers;
- acne vulgaris;
- hypersensitivity to alklomethasone or to any of the auxiliary components of the drug.
There is no established clinically significant drug interaction Afloderm with other drugs.
Pregnancy and Lactation
The use of Afloderm during pregnancy is possible only when the intended benefit to the mother outweighs the potential risk to the fetus. In such cases, the use of the drug should be short and limited to a small area of skin.
Data on the teratogenic effect of the drug are not available.
It is possible to use the drug Afloderm during lactation, but with the observance of precautions, in particular, the drug should not be applied to the skin of the mammary gland before feeding.
If at the first use of Afloderm hypersensitivity reactions develop (itching, burning and hyperemia), the drug should be discontinued.
Afloderm should not be applied to the skin in the eye area (due to the possible development of glaucoma and cataracts), as well as on open wound surfaces.
If the course of the disease is complicated by the development of a secondary bacterial or fungal infection, a specific antibacterial or antimycotic agent must be added to therapy with Afloderm.
Use in Pediatrics
The drug can be used in young children.
It should be borne in mind that in young children skin folds and diapers may have an effect similar to that of an occlusive dressing, and increase, accordingly, the systemic absorption of the active substance. In addition, children may have a greater degree of systemic absorption due to the ratio between the surface of the skin and body weight, as well as due to insufficient maturity of the epidermis. Therefore, long-term use in young children is possible only under the supervision of a physician.
Symptoms: development of systemic side effects of corticosteroids.
- Brand name: Afloderm
- Active ingredient: Alclomethasone
- Dosage form: Ointment for external use 0.05% from colorless to light yellow color, homogeneous, without mechanical inclusions.
- Manufacturer: Belupo
- Country of Origin: Croatia