Buy Afobazole pills 10 mg, 60 pcs
  • Buy Afobazole pills 10 mg, 60 pcs

Afobazole®

Afobazole is a novel anti-anxiety drug developed in russia. Afobazole does not cause sedation and is not addictive, unlike commonly used anxiety drugs. Besides having an anxiolytic action, afobazole is also shown to possess nootropic properties.

Pharmstandard
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2019-06-23
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Afobazole, also known as Fabomotizole, is a novel, non-benzodiazepine anxiolytic drug. It is approved for medical use in Russia to treat anxiety disorders.

The drug was discovered in 2000’s in Zakusov institute of pharmacology (Russia), the same institute that discovered nootropic drug Noopept and long-acting benzodiazepine tranquilizer Phenazepam.

Afobazole has a wide spectrum of clinical application as it has both anxiolytic and nootropic properties. Besides its main use for anxiety management, Afobazole also can be used in conjunction therapy for various somatic diseases. The official indications for use are:

  • Anxiety disorders
  • Irritable bowel syndrome
  • Anxiety-induced sleep disorders
  • Premenstrual syndrome
  • Alcohol withdrawal syndrome
  • Bronchial asthma
  • Systemic lupus erythematosus
  • Ischemic heart disease
  • Hypertension
  • Arrhythmia

Afobazole does not cause sedation and lacks hypnotic activity and abuse potential, unlike most drugs used for anxiety purposes. The dosage at which hypnosedative effects are observed is about 50 times higher than the effective therapeutic dose.

The relief of emotional as well as the physical symptoms of anxiety usually observed within a week after starting a treatment with Afobazole, with a peak effect at week 4.

The mechanism of action of Fabomotizole based on its ability to antagonize stress-induced changes of GABA/benzodiazepine receptor complex, and restore its sensitivity to the endogenous ligands. The drug does not binds to the benzodiazepine receptors and has no myorelaxant effects. According to the radioligand binding assay, Afobazol also have affinity with dopamine d1 and melatonin MT1/MT3 receptors, and is shown to inhibit MAO-A.

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Afobazole®

Dosage and Administration

Afobazole is prescribed by mouth, after eating. A single dose is 10 mg; daily dose - 30 mg, divided into 3 doses during the day. The duration of the course of the drug is 2-4 weeks. If necessary, the daily dose of the drug can be increased to 60 mg, and the duration of treatment up to 3 months.

Adverse reactions

Allergic reactions are possible.

Rarely - a headache that usually resolves on its own and does not require discontinuation of the drug.

  • pregnancy;
  • lactation period (breastfeeding);
  • age up to 18 years;
  • hypersensitivity to the components of Afobazole.

Drug interactions

With the simultaneous use of Afobazole does not affect the narcotic effect of ethanol and the hypnotic effect of thiopental. With the simultaneous use of Afobazole potentiates the anticonvulsant effect of carbamazepine. With simultaneous use of Afobazole increases the anxiolytic effect of diazepam.

Pregnancy and Lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Special instructions

The drug does not adversely affect the driving of motor vehicles and the performance of potentially hazardous activities that require high concentration of attention and speed of psychomotor reactions.

Overdosage

Symptoms: with a significant overdose and intoxication may develop a sedative effect and increased drowsiness without manifestations of muscle relaxation.
Treatment: as an emergency, n / a caffeine sodium benzoate 20% is prescribed, a solution of 1 ml 2-3 times / day.

  • Brand name: Afobazole
  • Active ingredient: Morpholinoethylthioethoxybenzimidazole
  • Dosage form: Pills
  • Manufacturer: Pharmstandard
  • Country of Origin: Russia

Studies and clinical trials of Afobazole (Click to expand)

  1. Allergic contact dermatitis from alclomethasone dipropionate
  2. Tissue availability of afobazole and its major metabolites in rats
  3. Neuroprotective effect of afobazole on rats with bilateral local photothrombosis of vessels in the prefrontal cortex
  4. Effect of afobazole on teratogenic activity of cyclophosphamide in rats
  5. Excretion of afobazole and its metabolites with urine and feces in rats
  6. Interaction of Afobazole with σ1-Receptors
  7. Effect of Afobazole on Mitochondrial Monoamine Oxidase A ActivityIn Vitro
  8. Effect of Afobazole on DNA Damage in Patients with Systemic Lupus Erythematosus
  9. Effects of Selective Anxiolytic Afobazole on Active Caspase-3
  10. Neuroprotective Properties of Afobazole in Repeated Hemorrhagic Stroke Modeling in Aged Rats
  11. cEffect of Afobazole on Genotoxic Effects of Tobacco Smoke in the Placenta and Embryonic Tissues of Rats
  12. On the Mechanism of Antifibrillatory Effect of Afobazole
  13. Comparative Analysis of Tissue Availability for Afobazole and Compound M-11
  14. Study of Anti-Ischemic Effect of Afobazole in Experimental Myocardial Infarction
  15. Effects of Afobazole on Cognitive Behavior of the Offspring of Rats Exposed to Tobacco Smoke during Gestation Period
  16. Effects of Afobazole on the Content of Neurotransmitter Amino Acids in the Striatum in Global Transient Ischemia
  17. Analysis and standardization of the new anxiolytic drug afobazole
  18. Developing analytical methods for afobazole in injection forms
  19. Pharmaceutical analysis and standardization of afobazole in solid dosage form (tablets)
  20. Synthesis and pharmacological activity of the main metabolite of afobazole and its analogs
  21. Development of a method for assessing the stability of afobazole by HPLC
  22. Development of synthesis technology for the selective anxiolytic drug afobazole
  23. Antimutagenic Activity of Afobazole in Various Regimens of Treatment
  24. Effect of Noopept and Afobazole on the Development of Neurosis of Learned Helplessness in Rats
  25. P.3.008 Ex vivo investigation of afobazole effect on H3-diazepam binding by synaptoneurosomal membranes of inbred mice and rats

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