Albarel® [Rilmenidine]

Brand Egis

In stock 1122 Items

Available since: 2019-09-19

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Clinical Pharmacology

Albarel is an antihypertensive drug, an oxazoline derivative.

Selectively interacts with the imidazoline receptor (I 1) of the cortical and peripheral vasomotor centers, in particular the renal centers. The binding of rilmenidine with imidazoline receptors inhibits the sympathomimetic activity of both cortical and peripheral centers, which leads to a decrease in blood pressure.
Albarel has a dose-dependent hypotensive effect on systolic and diastolic blood pressure while lying and standing. It has been shown that administration of the drug Albarel in therapeutic doses (1 or 2 mg / day) is effective in the treatment of mild and moderate arterial hypertension. The effect of the drug lasts for 24 hours, effective during physical exertion. With prolonged use, addiction does not develop.

In therapeutic doses, Albarel does not affect the function of the heart, does not cause sodium and water retention, does not disturb the metabolic equilibrium.
Albarel reduces OPS without changes in cardiac output. Myocardial contractility and electrophysiological indices remain unchanged.
Albarel does not cause orthostatic hypotension (including in the elderly); does not violate the compensatory physiological response of the heart rhythm to physical activity; does not affect the renal blood flow, glomerular filtration or filtration fraction; does not affect carbohydrate and lipid metabolism (including in patients with insulin-dependent and insulin-independent diabetes mellitus).

Indications

Arterial hypertension

Composition

1 tablet contains:
Active ingredients
Rilmenidine 1 mg.
Excipients
Sodium carboxymethyl starch, microcrystalline cellulose, lactose, paraffin, anhydrous colloidal silicon dioxide, magnesium stearate, talc, white beeswax.

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Dosage and Administration

When treating the drug Rilmenidine is taken orally (after eating) with water, according to the following scheme:
- for children from 1 year to 3 years - on day 1 10 ml (2 teaspoons) of syrup (20 mg) 3 times / day. (daily dose - 60 mg); in the 2nd and 3rd days - 10 ml 2 times / day. (daily dose - 40 mg), on the 4th day - 10 ml 1 time / day. (daily dose - 20 mg);
- for children from 3 to 7 years old - on the 1st day -15 ml (3 teaspoons) of syrup (30 mg) 3 times / day. (daily dose - 90 mg); in the 2nd and 3rd days - 3 teaspoons 2 times / day. (daily dose - 60 mg), on the 4th day - 3 teaspoons 1 time / day. (daily dose - 30 mg).
For the prevention of drug Rilmenidine prescribe:
- children from 1 year to 3 years - 10 ml (2 teaspoons) of syrup (20 mg) 1 time / day;
- children from 3 to 7 years old - 15 ml (3 teaspoons) of syrup (30 mg) 1 time / day. within 10-15 days depending on the source of infection.
The daily dose of rimantadine should not exceed 5 mg / kg body weight.

Adverse reactions

Rilmenidine is usually well tolerated. The following adverse reactions are sometimes observed.
On the part of the digestive system: nausea, vomiting, epigastric pain, flatulence, anorexia.
From the side of the central nervous system: headache, dizziness, insomnia, neurological reactions, impaired concentration.
Other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria), asthenia.

- acute liver disease;
- acute and chronic kidney disease;
- thyrotoxicosis;
- pregnancy;
- lactation period;
- children's age up to 1 year;

Contraindications

- Hypersensitivity to the components of the drug Rilmenidine.
With caution should be prescribed the drug for epilepsy (including in history).

Drug interactions

When combined, Rilmenidine® reduces the effectiveness of antiepileptic drugs.
When taken simultaneously, adsorbents, binders and coating agents reduce the absorption of rimantadine.
Drugs that acidify urine (acetazolamide, sodium bicarbonate), increase the effectiveness of rimantadine due to the reduction of its excretion by the kidneys.
When combined with the use of acetylsalicylic acid, paracetamol reduce the Cmax value of rimantadine by 11%.
Cimetidine reduces the clearance of rimantadine by 18%.

Pregnancy and Lactation

The drug Rilmenidine is contraindicated for use during pregnancy and lactation.

Special instructions

While taking the drug Rilmenidine, exacerbation of chronic comorbid diseases is possible.
When epilepsy increases the risk of developing an epileptic seizure.
Rilmenidine syrup contains 60% sucrose, which should be considered when prescribing the drug for diabetics.
Perhaps the emergence of drug-resistant viruses.