Buy Almagel gel 10 ml sachets 10 pcs
  • Buy Almagel gel 10 ml sachets 10 pcs

Almagel

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2019-09-19
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Clinical Pharmacology

Pharmacotherapeutic group

Antacid

ATC code: А02АХ

pharmachologic effect

Pharmacodynamics

Almagel® is a drug that is a balanced combination of algaldrate (aluminum hydroxide) and magnesium hydroxide. It neutralizes free hydrochloric acid in the stomach, reduces the activity of pepsin, which leads to a decrease in the digestive activity of gastric juice. It has an enveloping, adsorbing effect. It protects the gastric mucosa by stimulating the synthesis of prostaglandins (cytoprotective action). This protects the mucosa from inflammatory and erosive hemorrhagic lesions as a result of the use of irritating and ulcerogenic agents such as ethyl alcohol and nonsteroidal anti-inflammatory drugs (for example, indomethacin, diclofenac, aspirin, acetylsalicylic acid, corticosteroids). The therapeutic effect after taking the drug comes in 3-5 minutes. The duration of action depends on the rate of gastric emptying. When taken on an empty stomach, the effect lasts up to 60 minutes. When taken an hour after a meal, the antacid effect can last up to 3 hours. Does not cause secondary hypersecretion of gastric juice.

Pharmacokinetics

Algeldrat

Absorption - small amounts of the drug are resorbed, which practically do not change the concentration of aluminum salts in the blood.

Distribution - no.

Metabolism is not.

Excretion - is excreted through the intestines.

Magnesium hydroxide

Absorption - magnesium ions are resorbed in about 10% of the accepted dose and do not change the concentration of magnesium ions in the blood.

Distribution is usually local.

Metabolism is not. Excretion - is excreted through the intestines.

Indications

Treatment

  • Acute gastritis; chronic gastritis with increased and normal gastric secretion (in the acute phase); acute duodenitis, enteritis, colitis;
  • peptic ulcer and duodenal ulcer (in acute phase);
  • hiatal hernia, gastroesophageal reflux, reflux esophagitis, duodenogastric reflux;
  • symptomatic ulcers of the digestive tract of various origins; erosion of the mucous membrane of the upper gastrointestinal tract;
  • acute pancreatitis, exacerbation of chronic pancreatitis;
  • heartburn and epigastric pain after errors in nutrition, excessive use of ethanol, nicotine, coffee, taking medicines that irritate the gastric mucosa.
  • Prevention of gastric and duodenal disorders
  • reduction of irritant and ulcerogenic effects associated with taking medications that irritate the gastric mucosa.

Composition

10 ml (1 sachet) suspensions contain: Active ingredients: Aluminum hydroxide gel - 4.36 g in terms of Al2O3 - 436 mg Magnesium hydroxide Nast - 700 mg in terms of MgO - 150 mg Excipients: Hydrogen peroxide solution 30% - 0.82 mg, sorbitol - 1602.300 mg, gietelloza - 21.80 mg, methyl parahydroxybenzoate - 21.80 mg, propyl parahydroxybenzoate - 2.726 mg, butyl parahydroxybenzoate - 2.726 mg, sodium sugar, 6.66 mg, 16.66 mg, sodium sulfate, 16.66 mg, 16.66 mg, sodium sulfate, 16.66 mg, sodium sulfate, 16.2%, 16.66 mg, sodium sulfate, hexane hydroxybenzoate, hexane hydroxybenzoate, 2.726 mg, sorbitol, 2.726 mg, sorbitol, 2.726 mg 654.00 mg, macrogol 4000 - 436.00 mg, lemon oil - 3.27 mg, ethanol 96% - 196.20 mg, purified water to 10 ml.

Almagel is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Almagel gel
Almagel A Balkanpharma Bulgaria gel
Almagel Neo Balkanpharma Bulgaria gel
Almagel Balkanpharma Bulgaria gel

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Almagel

Dosage and Administration

Treatment

Adverse reactions

Almagel can cause constipation, which goes away after dose reduction.

In rare cases, nausea, vomiting, stomach cramps, changes in taste, allergic reactions and hypermagneemia (increased levels of magnesium in the blood) are observed. With prolonged use of the drug by patients with renal insufficiency and on dialysis, changes in mood and mental activity are possible; With long-term intake of high doses of the drug, along with a deficiency of phosphorus in food, it is possible - the occurrence of osteomalacia.

Contraindications

  • Hypersensitivity to the active or to any excipient, which is part of the drug.
  • Severe form of renal failure (due to the risk of hypermagnesia and aluminum intoxication).
  • Pregnancy.
  • Alzheimer's disease.
  • Hypophosphatemia.
  • Children's age up to 10 years.
  • Congenital fructose intolerance (contains sorbitol)

Drug interactions

It can absorb certain drugs, thus reducing their absorption, therefore, while taking other drugs, they must be taken 1-2 hours before or after taking Almagel.

Almagel reduces the acidity of gastric juice, and this can affect the action of a large number of drugs while taking.

Almagel reduces the effect of histamine H2-receptor blockers (cimetidine, ranitidine, famotidine), cardiac glycosides, iron salts, lithium preparations, quinidine, mexiletin, phenothiazine preparations, tetracycline antibiotics, ciprofloxacin, isoniazid and ketoconazaz.

With the simultaneous intake of enteric preparations, an elevated pH of the gastric juice can lead to an accelerated disruption of the membrane and irritate the stomach and duodenum. Almagel may affect the results of some laboratory and functional studies and tests: it reduces the level of gastric secretion in determining its acidity; alters test results using technetium (TC ??), such as bone scintigraphy and some tests for the study of the esophagus, increases the serum phosphorus level, pH values ​​of serum and urine.

Pregnancy and Lactation

Animal studies have shown that there is no evidence of teratogenic potential or other undesirable effects on the embryo and / or fetus.

There is no clinical data on the use of Almagel pregnant women. The drug is not recommended during pregnancy, but if the estimated benefits of its use outweighs the potential risk to the fetus, the drug should be taken under the supervision of a doctor for no more than 5-6 days.

There is no data on the release of the active substances of the drug in breast milk. Almagel can be used during breastfeeding only after a careful assessment of the ratio of benefits to the mother and the potential risk to the newborn.

During breastfeeding, it is recommended to use no more than 5-6 days under the supervision of a physician.

Special instructions

The use of the drug in patients with severe constipation is not recommended; with pain in the stomach of unknown origin and in case of suspected acute appendicitis; in the presence of ulcerative colitis, diverticulosis, colostomy or ileostomy; chronic diarrhea; acute hemorrhoids; when changing the acid-base balance in the body, as well as in the presence of metabolic alkalosis; in case of liver cirrhosis; severe heart failure; in case of toxicosis of pregnant women; with impaired renal function (creatinine clearance <30 ml="" min="" due="" to="" the="" risk="" of="" hypermagnesium="" and="" aluminum="" intoxication="" p="">

With prolonged use of the drug (more than 20 days), regular medical monitoring of the serum magnesium level is necessary when treating patients with renal insufficiency. The drug does not contain sugar, which allows you to take it to patients with diabetes. The drug contains sorbitol, which is contraindicated in congenital fructose intolerance.

The effect of the drug on the ability to drive vehicles and other mechanisms:

Almagel does not affect the ability to drive and work with mechanisms. When taken in the recommended daily dose, the ethyl alcohol contained in the preparation does not affect the ability to drive a car or work with mechanisms.

Overdosage

When a single dose is exceeded, no other signs of overdose are observed other than constipation, flatulence, metallic taste in the mouth.

With prolonged high doses, the formation of kidney stones, the appearance of severe constipation, mild drowsiness, and hypermagnemia are possible. There may also be signs of metabolic alkalosis: a change in mood or mental activity, numbness or pain in the muscles, irritability and fatigue, slowed breath, unpleasant taste sensations.

In these cases, you must immediately take measures for the rapid removal of the drug from the body - gastric lavage, stimulation of vomiting, taking activated charcoal.

  • Brand name: Almagel
  • Active ingredient: Algeldrat, Benzocaine, Magnesium hydroxide
  • Dosage form: Suspension for ingestion of 10 ml in a bag - 10 bags in a carton box
  • Manufacturer: Balkanpharma

Studies and clinical trials of Almagel (Click to expand)

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