

Amlodipine is a calcium channel blocker that is used to treat various heart conditions, such as chest pain and hypertension. Amlodipine often sold as combined medication, in combination with other cardiac drugs.
Amlodipine blocks the entry of calcium ions through the cell membranes into the smooth muscle cells of the myocardium and blood vessels. It has a direct relaxing effect on vascular smooth muscle, expands peripheral arterioles, which leads to a reduction in round neck, reduces the load on the heart and reduces the myocardial oxygen demand, expands the coronary arteries, increasing the oxygen supply to the myocardium.
1 tablet contains:
Active substance: Amlodipine 5 mg.
Amlodipine is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Amlovas | Yunik Pharmaceutical | India | pills |
Amlodipine | Canonpharma | Russia | pills |
Amlodipine | Hemofarm | Serbia | pills |
Amlodipine | Vertex | Russia | pills |
Amlorus | Synthesis AKOMP | Russia | pills |
Amlodipine Sandoz | Sandoz | Switzerland | pills |
Amlodipine-Teva | Teva | Israel | pills |
Amlotop | Hemofarm | Serbia | pills |
Tenox | Krka dd Novo mesto AO | Slovenia | pills |
Normodipine | Gedeon Richter | Hungary | pills |
Norvasc | Pfizer | USA | pills |
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Orally, the initial dose of 5 mg / day, if necessary, the daily dose may be increased to 10 mg. The maximum daily dose of 10 mg.
From the nervous system and sense organs: dizziness, headache, drowsiness, feeling tired; rarely, mood changes, asthenia, convulsions, myalgia, blurred vision, paresthesia.
Since the cardiovascular system and blood (hematopoiesis, hemostasis): palpitations, hot flashes.
On the part of the digestive tract: nausea, abdominal pain, dyspepsia; rarely - gingival hyperplasia, elevated levels of hepatic transaminases, jaundice.
From the genitourinary system: increased urination, swelling, impotence.
On the part of the skin: allergic reactions (skin rash, itching), rarely - erythema multiforme.
Other: rarely - shortness of breath, gynecomastia.
Hypersensitivity, hypotension.
Carefully: should be prescribed to patients with impaired liver function, stenosis of the aortic orifice, chronic heart failure.
It is possible only if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.
It should refrain from the use of the drug in pediatric practice, since the safety and efficacy of its use in children have not been determined.
Precautions should be prescribed to patients with impaired liver function, stenosis of the aortic mouth, and chronic heart failure.
Symptoms: severe hypotension.
Treatment: maintaining the function of the cardiovascular system, monitoring the performance of the heart and lungs, the elevated position of the extremities, control of the BCC and diuresis, the use of vasoconstrictor agents, the introduction of calcium gluconate (IV).
Studies and clinical trials of Amlodipine (Click to expand)