Amlodipine, Losartan

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Dosage and Administration

Dosage and Administration

Inside, 1 time per day, regardless of the time of the meal, with a small amount of water.

The recommended dose of the drug Lortenza - 1 table. / Day.

Lortensa drug at a dose of 5 + 50 mg is prescribed to patients who have not achieved adequate blood pressure control when using amlodipine at a dose of 5 mg or losartan at a dose of 50 mg in monotherapy.

Lortenza drug at a dose of 5 + 100 mg is prescribed to patients who have not achieved adequate blood pressure control when using losartan at a dose of 100 mg or Lortenza drug at a dose of 5 + 50 mg.

Lortenza drug at a dose of 10 + 50 mg is prescribed to patients who have not achieved adequate blood pressure control when using amlodipine at a dose of 10 mg or Lortenza drug at a dose of 5 + 50 mg.

Lortenza drug at a dose of 10 + 100 mg is prescribed to patients who have not achieved adequate blood pressure control with Lortenza at a dose of 5 + 100 mg or 10 + 50 mg.

The dose is selected after a previous titration of doses of individual components of the drug. If you need to change the dose of one of the active ingredients in the composition of a fixed combination drug (for example, in connection with a newly diagnosed disease, a change in the patient’s condition or drug interaction), an individual selection of doses of individual components is necessary.

The maximum daily dose is 10 + 100 mg.

Patients taking losartan and amlodipine at the same time can be transferred to Lawtenza, which contains losartan and amlodipine in the same doses.

Impaired renal function. With Cl creatinine from 50 to 20 ml / min, dose adjustment is not required.

Lortenza is contraindicated in patients with creatinine Cl less than 20 ml / min and in patients on hemodialysis (see “Contraindications”).

Patients with reduced BCC. In patients with reduced BCC (for example, due to treatment with high doses of diuretics, etc.), the initial dose of losartan should be reduced to 25 mg 1 time per day. In connection with the lack of a dosage of drug Lortenza containing 25 mg of losartan, this dose should be prescribed in losartan monotherapy.

Before using the drug Lortenza, it is necessary to restore the BCC and the sodium content in the blood plasma.

Liver dysfunction. In patients with impaired function (less than 9 points on the Child-Pugh scale) in history, lower doses of losartan are recommended. In connection with the lack of a dosage of drug Lortenza containing 25 mg of losartan, this dose should be prescribed in losartan monotherapy.

Use of the drug Lortenza is possible in patients with impaired liver function (less than 9 points on the Child-Pugh scale), who are recommended by the doctor to use losartan in a dose of 50 mg.

Elderly patients. Elderly patients do not require dose adjustment of Loretenza, but the dose should be increased carefully.

Children and teenagers. Lawtenza should not be prescribed to children and adolescents under the age of 18, because There are no data on the efficacy and safety of use in this group of patients.

Adverse reactions

Classification of the incidence of side effects WHO: very often - ≥1 / 10; often from ≥1 / 100 to <1/10; infrequently - from ≥1 / 1000 to <1/100; rarely from ≥1 / 10000 to <1/1000; very rarely - <1/10000; frequency unknown - cannot be estimated based on available data.

• Brand name: Lodoz
• Active ingredient: Amlodipine, Losartan
• Manufacturer: Merck sante

MedDRA	Unwanted effects	Development frequency
		Amlodipine	Losartan
Infectious and parasitic diseases	Urinary tract infection	—	Frequency unknown
Blood and lymphatic system	Leukopenia	Very rarely	—