Antigrippine-ANVI
Antiviral
686 Items
2019-09-19
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Clinical Pharmacology
The drug of the combined composition.
Acetylsalicylic acid possesses analgesic, antipyretic and anti-inflammatory effects; inhibits platelet aggregation.
Vitamin C plays an important role in the regulation of redox processes, carbohydrate metabolism, blood clotting, tissue regeneration, helps to increase the body's resistance.
Rutoside (rutin) is an angioprotector. Reduces capillary permeability, reduces swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of red blood cell deformation.
Metamizole Sodium It has analgesic, antipyretic and weak anti-inflammatory effects, the mechanism of which is associated with the inhibition of prostaglandin synthesis.
Diphenhydramine has antiallergic, anti-edema effect. Reduces vascular permeability, eliminates swelling and hyperemia of the nasal mucosa, sore throat and manifestations of allergic reactions from the upper respiratory tract.
Calcium gluconate It is a regulator of calcium and phosphorus metabolism, has anti-allergic effect (mechanism is unclear), reduces vascular permeability. In allergic diseases or conditions, its combined use with antihistamines is recommended.
Indications
Symptomatic treatment of influenza, ARVI, colds in adults and adolescents over 15 years.
Composition
1 capsule A contains:
Active substances:acetylsalicylic acid - 250 mg, ascorbic acid - 300 mg, rutoside - 20 mg.
Two types of capsules:
1 green capsule contains:
Active ingredients
- Acetylsalicylic acid 250 mg.
- Acorbic acid 300 mg.
- Rutin 20 mg.
Excipients: calcium stearate - 1 mg, potato starch - 9 mg.
The composition of hard gelatin capsules: gelatin - 90.723 mg, dye azorubine (E122) - 0.003 mg, brilliant black dye (E151) - 0.184 mg, blue patented dye (E131) or brilliant blue dye (E133) - 0.315 mg, quinoline yellow dye (E104) - 2.207 mg , titanium dioxide (E171) - 2.56 mg.
1 white capsule contains:
Active ingredients
- Metamizol 250 mg.
- Diphenhydramine 20 mg.
- Calcium gluconate 100 mg.
Excipients: calcium stearate - 3.8 mg, potato starch - 6.2 mg.
The composition of hard gelatin capsules: gelatin - 91.944 mg, titanium dioxide (E171) - 4.055 mg.
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Dosage and Administration
The drug is administered orally to adults and adolescents over 15 years old in 2 capsules per reception: 1 green capsule (from blister A) and 1 white capsule (from blister B).
The duration of treatment is 3-5 days until the symptoms of the disease disappear.
Capsules are taken orally 2-3 times a day after meals with water. The patient should be warned that in the absence of improvement in health, taking the drug should be stopped and consult a doctor.
Adverse reactions
From the digestive system: anorexia, nausea, vomiting, gastralgia, diarrhea, erosive and ulcerative gastrointestinal lesions, gastrointestinal bleeding, hepatic failure.
From the urinary system: renal failure.
Since the cardiovascular system: increased blood pressure, tachycardia.
Allergic reactions: skin rash, angioedema, bronchospasm.
Side effects observed with prolonged use of the drug (more than 7 days)
From the side of the central nervous system: dizziness, headache.
From the senses: visual disturbances, tinnitus, deafness.
From the hemopoietic system: leukopenia, thrombocytopenia, agranulocytosis.
On the part of the respiratory system: with a tendency to bronchospasm may provoke an attack.
From the blood coagulation system: reduction of platelet aggregation, hypocoagulation, hemorrhagic syndrome (including nosebleeds, gingival bleeding, purpura).
Allergic reactions: anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
From the urinary system: kidney damage with papillary necrosis, renal dysfunction, oliguria, anuria, proteinuria, interstitial nephritis, urine staining in red due to the release of the metabolite.
Other: in children - Reye's syndrome (hyperpyrexia, metabolic acidosis, disorders of the nervous system and psyche, vomiting, liver dysfunction).
The patient should be warned that all side effects, including not listed above, you should inform your doctor and stop taking the drug.
Carefully: prescribe the drug for hyperuricemia, urate nephrolithiasis, gout, gastric ulcer and duodenal ulcer (history), decompensated heart failure.
Drug interactions
With the simultaneous use of Antigrippine-ANVI enhances the action of heparin, indirect anticoagulants, reserpine, steroid hormones and hypoglycemic agents.
With the simultaneous use of Antigrippine-ANVI reduces the effectiveness of spironolactone, furosemide, antihypertensive and uricosuric drugs.
Antigrippine-ANVI enhances adverse reactions of GCS, sulfonylurea derivatives, methotrexate, non-narcotic analgesics and NSAIDs.
With simultaneous use of the drug Antigrippine-ANVI with barbiturates, antiepileptic drugs, zidovudine, rifampicin and ethanol-containing drugs increases the risk of hepatotoxic action. These combinations should be avoided.
Ascorbic acid improves intestinal absorption of iron preparations.
Tricyclic antidepressants, oral contraceptives and allopurinol violate the metabolism of metamizol in the liver and increase its toxicity.
Metamizole sodium enhances the effects of alcohol-containing beverages.
The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood plasma.
With simultaneous use with sodium metamizole, thiamazole and melphalan increase the risk of leukopenia.
Sedatives and tranquilizers enhance the analgesic effect of metamizole sodium.
Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during the administration of metamizole sodium.
Pregnancy and Lactation
The drug is contraindicated for use in pregnancy.If necessary, the appointment during lactation should stop breastfeeding for the period of use of the drug.
Acetylsalicylic acid has a teratogenic effect: when applied in the first trimester of pregnancy leads to the development of splitting of the upper palate; in the third trimester - to premature closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the pulmonary circulation, and inhibition of labor activity (due to inhibition of prostaglandin synthesis).
Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets.
Special instructions
The drug is not prescribed as an antipyretic. children under 15 years old with acute respiratory viral diseases due to the risk of Reye's syndrome (encephalopathy and acute fatty liver with acute development of liver failure).
With prolonged use of the drug is necessary to control the picture of peripheral blood and laboratory parameters of the functional state of the liver.
Since acetylsalicylic acid has an antiplatelet effect, the patient, if he is to undergo surgery, must notify the doctor in advance about taking the drug.
Acetylsalicylic acid in low doses reduces the excretion of uric acid, which can in some cases provoke an attack of gout.
Against the background of the use of the drug, patients should avoid drinking alcohol-containing drinks because of the increased risk of gastrointestinal bleeding.
Acetylsalicylic acid has a teratogenic effect: when applied in the first trimester of pregnancy leads to the development of splitting of the upper palate; in the third trimester - to premature closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the pulmonary circulation, and inhibition of labor activity (due to inhibition of prostaglandin synthesis).
Acetylsalicylic acid is excreted in breast milk, which increases the risk of bleeding in a child due to dysfunction of platelets.
In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the kidney function and blood pressure.
The administration of ascorbic acid to patients with rapidly proliferating and intensely metastatic tumors can aggravate the process.
Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (determination of glucose, bilirubin and activity of "liver" transaminases, LDH in blood plasma).
In patients with asthma and hay fever when taking the drug may develop hypersensitivity reactions.
Influence on ability to drive motor transport and control mechanisms
During the period of use of the drug should refrain from engaging in potentially hazardous activities that require increased attention and speed of psychomotor reactions.
Overdosage
Symptoms: nausea, vomiting, stomach pain, sweating, pale skin, tachycardia; with a slight overdose - ringing in the ears; in severe overdose - drowsiness, collapse, convulsions, bronchospasm, difficulty breathing, anuria, bleeding, progressive respiratory paralysis and respiratory acidosis (due to dissociation of oxidative phosphorylation).
Treatment: artificial vomiting, gastric lavage, the appointment of saline laxatives, Activated charcoal; with the development of convulsive syndrome - IV the introduction of diazepam and barbiturates; if necessary - conducting forced diuresis, hemodialysis.
- Brand name: Antigrippine-ANVI
- Active ingredient: Ascorbic to-that, Acetilsalicylic to-that, Rutozid, Metamizol of sodium, Calcium gluconate, Difengidromi
- Dosage form: Antigrippine-ANVI. Capsules
- Manufacturer: Antiviral
- Country of Origin: Russia
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