Buy Apilak pills 10 mg 50 pcs
  • Buy Apilak pills 10 mg 50 pcs

Apilak

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2019-06-23
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Clinical Pharmacology

Apilac (royal jelly) is a secret produced by the allotrophic glands of worker bees. Vitamins, macro- and microelements, amino acids, including essential, a number of other biologically active substances are found in apilac. It has a general tonic effect, stimulates cellular metabolism.

Indications

  • the recovery period after illness;
  • violation of lactation (hypogalactia) in the postpartum period;
  • as an aid in the treatment of neurotic disorders and arterial hypotension.

Composition

1 tablet contains:
active substance: dried royal jelly lyophilized - 10 mg;
Excipients: lactose monohydrate, talc, calcium stearate, potato starch.

Apilak is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Apilak Grindex Latvia pills
Apilak Vifitekh TOO Russia pills

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Apilak

Dosage and Administration

Inside
Dissolve the tablet in half past the hot water. Use immediately after dissolving. Stir before use.
Adults: take 1 tablet 2-3 times a day after meals for 3-5 days (no more than 5 days) until the symptoms of the disease disappear.
If there is no improvement in well-being, the drug should be stopped and consult a doctor.

Adverse reactions

In accordance with the constituent components.
From the side of the central nervous system: irritability, drowsiness, tremor, hyperkinesia, dizziness, headache, flushing of the blood to the face.
On the part of the digestive system: damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membranes in the mouth, lack of appetite, bloating (flatulence), diarrhea (diarrhea).
On the part of the urinary system: moderate pollakiuria.
From the side of blood-forming organs: changes in blood parameters. Control is needed.
Allergic reactions: angioedema, anaphylactic shock, skin rash, pruritus, urticaria.
On the part of the skin: Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), and acute generalized exantematous emptying.
Other: inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glycosuria).
If any of the side effects indicated in the instructions are aggravated, or you have noticed any other side effects that are not indicated in the instructions, inform your doctor immediately.

Hypersensitivity to one or more components that make up the drug; erosive and ulcerative lesions of the gastrointestinal tract in the acute phase; gastrointestinal bleeding; hemophilia; hemorrhagic diathesis; hypoprothrombinemia; portal hypertension; avitaminosis K; renal failure; pregnancy, breastfeeding period; diseases of the thyroid gland, acute diseases of the kidneys, liver (acute glomerulonephritis, acute pyelonephritis, acute hepatitis, or exacerbation of chronic diseases of these organs); chronic alcoholism; hypercalcemia, severe hypercalciuria, nephrolurithiasis, sarcoidosis, concomitant use of cardiac glycosides (risk of arrhythmias); fructose intolerance; phenylketonuria.
Children's age up to 18 years.
Carefully
Restricting use of epilepsy ), hypercalciuria; simultaneous or during the previous 2 weeks taking monoamine oxidase inhibitors, tricyclic antidepressants; while taking drugs that can adversely affect the liver (for example, inducers of microsomal liver enzymes). Care should be taken when treating patients with recurrent formation of urate kidney stones; progressive malignant diseases; bronchial asthma.
Elderly patients with arterial hypertension (the risk of hemorrhagic stroke increases, due to rimantadine, which is part of the drug).

Drug interactions

Paracetamol reduces the efficacy of uricosuric drugs. The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs. Inductors of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxication even with a small overdose.With simultaneous use with metoclopramide may increase the rate of absorption of paracetamol. Prolonged use of barbiturates reduces the effectiveness of paracetamol. Inhibitors of microsomal oxidation reduce the risk of hepatotoxic action.
Rimantadin stimulates the stimulating effect of caffeine. Cimetidine reduces the clearance of rimantadine by 18%.
Ascorbic acid increases the concentration of benzylpenicillin in the blood. It improves the absorption of iron preparations in the intestine (converts ferric iron to ferrous iron); may increase the excretion of iron while using with deferoxamine. Increases the risk of crystalluria in the treatment of short-acting salicylates and sulfonamides, slows the kidneys excretion of acids, increases the excretion of drugs having an alkaline reaction (including alkaloids). Reduces the concentration in the blood of oral contraceptives. Increases total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. With simultaneous use reduces the chronotropic effect of isoprenaline. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.
Loratadine. Inhibitors of CYP3A4 and CYP2D6 increase the concentration of loratadine in the blood.

Pregnancy and Lactation

Use during pregnancy and during breastfeeding is contraindicated.

Special instructions

Duration of use - no more than 5 days.
Do not use in the presence of metastatic tumors.
Persons prone to ethanol use should consult a doctor before starting treatment with the drug, since paracetamol may have a damaging effect on the liver.

Impact on the ability to drive vehicles and other mechanisms that require increased concentration of attention: during the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Overdosage

  • Symptoms: during the first 24 hours after administration - pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region; violation of glucose metabolism, metabolic acidosis (including lactic acidosis), hypokalemia, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases. Symptoms of abnormal liver function may appear 12-48 hours after an overdose. In severe overdose - liver failure with progressive encephalopathy, coma; acute renal failure with tubular necrosis (including in the absence of severe liver damage). The overdose threshold may be reduced in elderly patients, in patients taking certain drugs (for example, inducers of microsomal liver enzymes), alcohol or suffering from depletion.
  • Treatment: the introduction of SH-group donators and precursors of the synthesis of glutathione - methionine within 8-9 hours after overdose and acetylcysteine ​​- within 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further introduction of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.
  • Brand name: AnviMax®
  • Active ingredient: Paracetamol, Ascorbic acid, Rimantadine, Rutozid, Loratadine, Calcium gluconate
  • Dosage form: Effervescent pills [with cranberry taste and aroma], effervescent pills [with raspberry taste and aroma]. On 10 pills in a tub from polypropylene complete with a cover from polyethylene with a silica gel insert.
    On 1 tuba together with the application instruction in a pack from a cardboard.
  • Manufacturer: FarmVILAR FPK

Studies and clinical trials of Apilak (Click to expand)

  1. ChemInform Abstract: Synthesis and Structure—Activity Relationship of 2-Thiopyrimidine-4-one Analogues as Antimicrobial and Anticancer Agents.
  2. Lower BMI cutoff for assessing the prevalence of metabolic syndrome in Thai population
  3. Predicting the free radical scavenging activity of curcumin derivatives
  4. Enhancing the value of nitrogen from rapeseed meal for microbial oil production
  5. Identification of metabolic syndrome using decision tree analysis
  6. Synthesis and structure–activity relationship of 2-thiopyrimidine-4-one analogs as antimicrobial and anticancer agents
  7. Antioxidant, cytotoxicity, and QSAR study of 1-adamantylthio derivatives of 3-picoline and phenylpyridines
  8. Predicting antimicrobial activities of benzimidazole derivatives
  9. Synthesis of N-Substituted 5-Iodouracils as Antimicrobial and Anticancer Agents
  10. Bioactive Metabolites from Spilanthes acmella Murr.
  11. Synthesis, cytotoxicity and QSAR study ofN-tosyl-1,2,3,4-tetrahydroisoquinoline derivatives
  12. Exploring the chemical space of aromatase inhibitors
  13. Cytotoxicity and QSAR study of (thio)ureas derived from phenylalkylamines and pyridylalkylamines
  14. QSAR study of amidino bis-benzimidazole derivatives as potent anti-malarial agents againstPlasmodium falciparum
  15. QSAR modeling of aromatase inhibitory activity of 1-substituted 1,2,3-triazole analogs of letrozole
  16. Predictive QSAR modeling of aldose reductase inhibitors using Monte Carlo feature selection
  17. Insights into antioxidant activity of 1-adamantylthiopyridine analogs using multiple linear regression
  18. Antioxidant and antimicrobial activities of Saraca thaipingensis Cantley ex Prain
  19. Determining the optimal cutoff points for waist circumference and body mass index for identification of metabolic abnormalities and metabolic syndrome in urban Thai population
  20. QSAR modeling of aromatase inhibition by flavonoids using machine learning approaches
  21. Synthesis, anticancer activity and QSAR study of 1,4-naphthoquinone derivatives
  22. Large-scale QSAR study of aromatase inhibitors using SMILES-based descriptors
  23. Use of Apilak (Royal jelly) in sports medicine
  24. Probing the origins of anticancer activity of chrysin derivatives

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