Buy Argosulfan cream 2%, 15 g
  • Buy Argosulfan cream 2%, 15 g

Argosulfan® [Sulfadiazine silver]

Elfa Pharmaceutical Plant
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Clinical Pharmacology

Argosulfan cream is a topical antibacterial drug that promotes healing of wounds (burns, trophic, purulent, etc.), provides effective protection of wounds against infection, relieves pain and burning sensation in the wound, reduces the time of treatment and preparation of the wound for skin grafts, in many cases leads to an improvement in condition that eliminates the need for transplantation.

The sulfanilamide - sulfathiazol, which is part of the cream, has a wide spectrum of antibacterial bacteriostatic action against gram-positive and gram-negative bacteria. The mechanism of the antimicrobial action of sulfathiazole - the inhibition of growth and reproduction of microbes - is associated with competitive antagonism with PABA and the inhibition of dihydropteroate synthetase, which leads to a violation of the synthesis of dihydrofolic acid and, ultimately, its active metabolite - tetrahydrofolic acid, necessary for the synthesis of purines and the gymnastics that are necessary for the synthesis of purines and in the synthesis of purines and diagrams, which are necessary for the synthesis of purines and objects, which are used for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and objects, for the synthesis of purines and irides, for the synthesis of purines and irides, which are necessary for the synthesis of purines and for the synthesis of purines and objects; The silver ions present in the preparation enhance the antibacterial action of sulfanilamide several dozen times - they inhibit the growth and division of bacteria by binding to the microbial cell DNA. In addition, silver ions weaken the sensitizing properties of sulfanilamide.

Due to the hydrophilic base of the cream, which has an optimal pH and contains a large amount of water, it has an analgesic effect and moisturizing the wound, contributing to good tolerance, facilitating and accelerating wound healing.


  • Burns of varying degrees, of any nature (thermal, solar, chemical, electric current, radiation, etc.), frostbite.
  • Bedsores, trophic ulcers of the lower leg of various genesis (including chronic venous insufficiency, obliterating endarteritis, circulatory disorders in diabetes, erysipelas, etc.).
  • Purulent wounds, minor household injuries (cuts, abrasions).
  • Infected dermatitis, simple contact dermatitis, complicated impetigo, microbial eczema, streptostaphyloderma.


1 g of cream contains:

Active ingredient: Sulfadiazine silver salt 20 mg.

The foundation: up to 1 year

Main components: liquid paraffin; cetostearyl alcohol; petrolatum; sodium lauryl sulfate; glycerol; propyl hydroxybenzoate; methyl hydroxybenzoate; potassium hydrogen phosphate; sodium dihydrophosphate; water for injections.

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Argosulfan® [Sulfadiazine silver]

Dosage and Administration

Topically. Apply on the skin 1 time per day, in the evening, for 7-10 days. After the treatment, take a bath, change the underwear and bed linen.

Adverse reactions

Allergic reactions.


Individual intolerance to the components of the drug.

  • Brand name: Argosulfan
  • Active ingredient: Sulfadiazine silver
  • Dosage form: Cream.
  • Manufacturer: Elfa Pharmaceutical Plant
  • Country of Origin: Poland

Studies and clinical trials of Sulfadiazine silver (Click to expand)

  1. Development of an artificial dermis preparation capable of silver sulfadiazine release
  2. Mechanical properties and release studies of chitosan films impregnated with silver sulfadiazine
  3. Silver Succinylsulfadiazine and Silver Sulfadiazine Imidazole: Two New Derivatives of the Antibacterial Silver Sulfadiazine
  4. A silver-sulfadiazine-impregnated synthetic wound dressing composed of poly-l-leucine spongy matrix: An evaluation of clinical cases
  5. Efficiency of controlled topical delivery of silver sulfadiazine in infected burn wounds
  6. Design and delivery of silver sulfadiazine from alginate microspheres-impregnated collagen scaffold
  7. IPM/DOSS/water microemulsions as reactors for silver sulfadiazine nanocrystal synthesis
  8. Characterization of silver sulfadiazine and related compounds
  9. Inhibition of supraeschar and subeschar Pseudomonas infection by silver sulfadiazine dry foam
  10. Solubility studies of silver sulfadiazine
  11. Liposome-encapsulated silver sulfadiazine (SSD) for the topical treatment of infected burns: Thermodynamics of drug encapsulation and kinetics of drug release
  12. Reversal of silver sulfadiazine-impaired wound healing by epidermal growth factor
  13. Photoproperties of silver sulfadiazine
  14. In vivo and in vitro antimicrobial activity of silver sulfadiazine and cerium nitrate: Saffer LD, Rodeheaver GT, Hiebert JM, et al, Surg Gyencol Obstet 151:232–236, (Aug) 1980
  15. Comparative trial of octyl-cyanoacrylate and silver sulfadiazine for the treatment of full-thickness skin wounds
  16. Laminin Modified Infection-Preventing Collagen Membrane Containing Silver Sulfadiazine–Hyaluronan Microparticles
  17. Synthesis, physical properties and microbiological activities of more water soluble silver sulfadiazine derivatives
  18. Effect of topically applied silver sulfadiazine on fibroblast cell proliferation and biomechanical properties of the wound
  19. Evaluation of a triple-lumen central venous heparin-coated catheter versus a catheter coated with chlorhexidine and silver sulfadiazine in critically ill patients
  20. Prevention of intravascular catheter-related infection with newer chlorhexidine-silver sulfadiazine-coated catheters: a randomized controlled trial
  21. Internally coated endotracheal tubes with silver sulfadiazine in polyurethane to prevent bacterial colonization: a clinical trial
  22. Reduction of catheter-related infections in neutropenic patients: a prospective controlled randomized trial using a chlorhexidine and silver sulfadiazine-impregnated central venous catheter
  23. Chlorhexidine and silver-sulfadiazine coated central venous catheters in haematological patients—a double-blind, randomised, prospective, controlled trial
  24. Antimicrobial chlorhexidine/silver sulfadiazine-coated central venous catheters versus those uncoated in patients undergoing allogeneic stem cell transplantation

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