Ascorbic acid
Uralbiopharm
1984 Items
2019-09-19
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Clinical Pharmacology
Ascorbic acid has pronounced reducing properties, is involved in the regulation of carbohydrate metabolism, redox processes, blood clotting, normalization of capillary permeability, tissue regeneration, the synthesis of steroid hormones, collagen, procollagen.
Indications
Used for prophylactic and therapeutic purposes in all clinical situations related to the need for additional administration of vitamin C. It is prescribed for the prevention and treatment of scurvy, for bleeding (nose, lung, uterine, caused by radiation sickness), hemorrhagic diathesis, for various intoxications and infectious diseases , nephropathies of pregnant women, Addison's disease, in case of overdose of anticoagulants, bone fractures and slow-healing wounds, various dystrophies, with increased mental stress and increased physical skom work.
Composition
1 dr. Contains ascorbic acid 50 mg
Ascorbic acid is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Vitamin C (Uralbiopharm | Uralbiopharm | Russia | dragee |
| Vitamin C | Pharmstandard Ufavita | Russia | dragee |
| Vitamin C | tea bags | ||
| Vitamin C | powder | ||
| Askorbinka | pills | ||
| Ascorbic acid with glucose | pills | ||
| Supra vit | Candy Ltd BG | Bulgaria | effervescent pills |
| Vitamin C | Evalar | Russia | effervescent pills |
| Askorbinka | Farm Tigoda | Russia | Other |
| Vitamin C | Cesena | Russia | dragee |
| Ascorbic Acid Twist with Sugar | Square-C | Russia | Other |
| Ascorbic Acid Twist with Sugar | Pharmaceutical industry | Russia | Other |
| Ascorbic Acid Twist with Sugar | Askoprom | Russia | Other |
| Vitamin C | Marbiopharm | Russia | pills |
| Ascorbic Acid Injection | Armavir biological factory | Russia | ampoules |
| Citrogex | Malkuth | Belarus | pills |
| Askorbinka | Ecopharm | Russia | Other |
| Ascorbic Acid | Vitamin C) Powder (Meligen | Russia | tea bags |
| Asvitol | Pharmstandard | Russia | pills |
| Ascorbic Acid Twist with Sugar | Ecopharm | Russia | Other |
| Askovit | Natur Product Pharma | Poland | effervescent pills |
| Vitamin C | effervescent pills | ||
| Vitamin C | Hemofarm | Serbia | effervescent pills |
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Dosage and Administration
For prophylactic purposes for adults - 0.05-0.1 g per day; during pregnancy, in the postpartum period and in the case of a low content of vitamin C in the milk of lactating women — 0.3 g per day for 10–15 days, and then prophylactically at 0.1 g per day during the entire lactation period. Children in order to prevent - 0.025 g 2-3 times a day. Therapeutic doses for adults - 0.05-0.1 g 3-5 times a day. Children - at 0.05-0.1 g 2-3 times a day.
Adverse reactions
From the side of the central nervous system: with rapid intravenous administration - dizziness, feeling tired, with prolonged use of large doses (more than 1 g) - headache, increased excitability of the central nervous system, insomnia.
Contraindications
Hypersensitivity, with prolonged use in large doses (more than 500 mg) - diabetes, hyperoxaluria, nephrolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficiency.
Drug interactions
Pharmaceutically incompatible with aminophylline, bleomycin, cefazolin, cefapirin, chlordiazepoxide, estrogens, dextrans, doxapram, erythromycin, methicillin, nafcillin, benzylpenicillin, warfarin.
Pregnancy and Lactation
The minimum daily need for ascorbic acid in the II-III trimesters of pregnancy is about 60 mg.
The minimum daily need during the lactation period is 80 mg. A mother's diet that contains an adequate amount of ascorbic acid is sufficient to prevent vitamin C deficiency in an infant (it is recommended not to exceed the maximum daily ascorbic acid need by a nursing mother)
Special instructions
In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor the function of the adrenal glands and blood pressure. High doses of ascorbic acid increase the excretion of oxalate, contributing to the formation of kidney stones. In newborns whose mothers took high doses of ascorbic acid, and in adults who took high doses, a ricochet of scurvy could be observed. With long-term use of large doses, the function of the insular apparatus of the pancreas may be inhibited, therefore during treatment it must be regularly monitored. In patients with a high content of iron in the body, ascorbic acid should be used in minimal doses. Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood and urine glucose, bilirubin, liver transaminases and lactate dehydrogenase activity).
Overdosage
Symptoms: If taken more than 1 g / day, heartburn, diarrhea, difficulty urinating or dyeing urine red, hemolysis are possible. (in patients with glucose-6-phosphate dehydrogenase deficiency).
Treatment: symptomatic, forced diuresis.
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- Anemia related to ascorbic acid deficiency
- Influence of System Composition on Ascorbic Acid Destruction at Processing Temperatures
- The effect of addedL-ascorbic acid, and sodium chloride on the change in concentration of some volatiles in pressurised peach homogenate during storage
- Effect of ascorbic acid addition to peppers on paprika quality
- PlantL-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing
- Stage and organ dependent effects of 1- O-hexyl-2,3,5-trimethylhydroquinone, ascorbic acid derivatives, N-heptadecane-8,10-dione and phenylethyl isothiocyanate in a rat multiorgan carcinogenesis model
- Chloroperoxidase-catalyzed enantioselective oxidation of methyl phenyl sulfide with dihydroxyfumaric acid/oxygen or ascorbic acid/oxygen as oxidants
- A kinetic study of electron transfer from L-Ascorbic acid to sodium perborate and potassium peroxy disulphate in aqueous acid and micellar media
- Preparation of monodisperse polystyrene spheres incorporating polyimide prepolymer by dispersion polymerization in the presence of L-ascorbic acid
- Effects of polyelectrolyte complex (PEC) on human periodontal ligament fibroblast (HPLF) function. II. Enhancement of HPLF differentiation and aggregation on PEC by L-ascorbic acid and dexamethasone
- Rapid chondrocyte maturation by serum-free culture with BMP-2 and ascorbic acid
- Osteoblastic phenotype of rat marrow stromal cells cultured in the presence of dexamethasone, β-glycerolphosphate, and L-ascorbic acid
- Regulation of growth, protein synthesis, and maturation of fetal bovine epiphyseal chondrocytes grown in high-density culture in the presence of ascorbic acid, retinoic acid, and dihydrocytochalasin B
- Modulation of chondrocyte proliferation by ascorbic acid and BMP-2
- Glucocorticoid stimulation of Na+-dependent ascorbic acid transport in osteoblast-like cells
- Antimutagenic and promutagenic activity of ascorbic acid during oxidative stress
- Ascorbic acid-dehydroascorbate induces cell cycle arrest at G2/M DNA damage checkpoint during oxidative stress
- Determination of ascorbic acid in nanolitre samples by means of capillary batch injection analysis
- Role of ascorbic acid in cadmium-induced thyroid dysfunction and lipid peroxidation
- Comparative effects of de-aeration and package permeability on ascorbic acid loss in refrigerated orange juice
- Simultaneous Determination of Ascorbic Acid and Dehydroascorbic Acid in Plant Materials by High Performance Liquid Chromatography
- Ascorbic and uric acid responses to xanthotoxin ingestion in a generalist and a specialist caterpillar
- Pharmacologic application of FTIR spectroscopy: Effect of ascorbic acid-induced free radicals on Deinococcus radiodurans
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