Aspirin Complex
Bayer Pharma AG
1583 Items
2019-09-19
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Clinical Pharmacology
Aspirin Complex is a combination drug.
Acetylsalicylic acid has antipyretic, analgesic and anti-inflammatory effects, and also reduces platelet aggregation.
Phenylephrine It is a sympathomimetic and, having a vasoconstrictor effect, reduces swelling of the mucous membranes of the nose and paranasal sinuses, resulting in easier breathing.
Chlorphenamine - histamine H blocker1-receptors, has anti-allergic effect: eliminates itching (including eyes, nose), swelling and hyperemia of the mucous membranes of the nasal cavity, nasopharynx and sinuses, reduces the phenomenon of exudation.
Indications
Use to relieve symptoms of “colds”, acute respiratory viral infections, flu, such as: fever and chills, headache and muscle pain, runny nose and / or nasal congestion, sore throat and sneezing.
Composition
Each bag contains: active ingredients: acetylsalicylic acid - 500 mg, phenylephrine hydrotartrate - 15.58 mg, chlorphenamine maleate - 2.00 mg; excipients: anhydrous citric acid 1220 mg, sodium bicarbonate 1709.6 mg, lemon flavor 100 mg, quinoline yellow dye (E 104) 0.32 mg.
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Dosage and Administration
Adults and children over the age of 15 are prescribed 1 sachet every 6-8 hours. The maximum daily dose is 4 sachets, the interval between doses of the drug should be at least 6 hours.
The duration of treatment (without consulting a doctor) should not exceed 5 days when used as an anesthetic and more than 3 days as an antipyretic.
The drug should be taken orally after eating, after dissolving the contents of the bag in a glass of water at room temperature.
Adverse reactions
From the digestive tract: nausea, anorexia, epigastric pain are possible; in some cases (especially with frequent and long-term use of the drug) - erosive and ulcerative lesions of the gastrointestinal tract, hidden blood loss from the gastrointestinal tract, signs of gastrointestinal bleeding (tarry stools).
From the hemopoietic system: very rarely - thrombocytopenia, anemia (due to hidden bleeding from the gastrointestinal tract).
Allergic reactions: rarely (especially in patients with bronchial asthma) - skin rash, bronchospasm.
Contraindications
The drug is not prescribed to children under the age of 15 years with acute respiratory infections caused by viral infections, because of the risk of Reye's syndrome (encephalopathy and acute fatty liver with acute development of liver failure).
WITHcaution should be prescribed the drug for gout, hyperuricemia; patients with a history of indications of ulcerative lesions of the gastrointestinal tract (including gastric ulcer and duodenal ulcer) or gastrointestinal bleeding, impaired kidney and liver function, bronchial asthma, chronic diseases of the respiratory organs, hay fever, nasal mucosa polyposis ; in case of allergic reactions to medicines (including NSAIDs), in the II trimester of pregnancy.
Drug interactions
Acetylsalicylic acid
Combination with Methotrexate at a dose of> 15 mg per week is contraindicated. Combinations of drugs that are used with caution: Methotrexate at a dose of less than 15 mg / week: The simultaneous use of drugs increases the hematological toxicity of methotrexate due to the fact that NSAIDs generally reduce the renal clearance of methotrexate, and salicylags, in particular, displace it from the association with plasma proteins.
Anticoagulants (coumarin, heparin): At the same time taking ASA and indirect atico-coagulants, the risk of bleeding increases due to the suppression of platelet function, damage to the mucous membrane of the stomach and duodenum, and the displacement of oral anticoagulants from their plasma proteins.
Other NSAIDs with salicylates in high dose (at a dose of 3 g / day or more): with simultaneous use of drugs due to the effect of synergism increases the risk of ulceration of the mucous membrane of the gastrointestinal tract and bleeding.
Uricosuric drugs (probenecid, sulfinpyrazon): The therapeutic effect of uricosuric drugs is reduced due to competitive tubular elimination of uric acid.
Digoxin: with simultaneous use of drugs increases the concentration of digoxin in the plasma by reducing its excretion.
Antidiabetic drugs (insulin, sulfonylurea): hypoglycemic effect is enhanced due to the fact that high-dose ASA has hypoglycemic properties and displaces the sulfonylurea from the bond with plasma proteins.
Thrombolytic / antiplatelet drugs of other classes (ticlopidine): increases the risk of bleeding.
Diuretics in combination with ASA in a dose of 3 g / day or more: glomerular filtration decreases due to a decrease in prostaglandin synthesis in the kidneys.
Systemic glucocorticosteroids (GCS) with the exception of hydrocortisone (used to treat Addison's disease): With the simultaneous use of drugs, the concentration of salicylates in the blood decreases, because GCS enhances the elimination of salicylates.
Angiotensin-converting enzyme (ACE) inhibitors: with simultaneous use of ACE inhibitors and ASA at a dose of 3 g / day or more, a decrease in the hypotensive effect of ACE inhibitors is observed, due to a decrease in glomerular filtration.
Valproic acid: ASC disrupts the association of valproic acid with plasma proteins, resulting in increased toxicity.
Alcohol: when combined with ASA, the damaging effect on the mucous membrane of the gastrointestinal tract increases and the bleeding time is prolonged.
Phenylephrine
Monoamine oxidase inhibitors (MAO inhibitors) - with simultaneous use of phenylephrine and MAO inhibitors (antidepressants - tranylcypromine, moclobemide; anti-parkinsonian drugs - selegilin), severe side effects are possible in the form of intense headache, high blood pressure and body temperature.
Beta blockers - with simultaneous use may increase blood pressure (hypertension) and severe bradycardia. Sympathomimetics with simultaneous use increases the effect of sympathomimetics on the central nervous system and the cardiovascular system. Possible excitement, irritability, insomnia.
Inhalation Anesthetics - The use of filylephrine before inhalation anesthesia increases the risk of heart rhythm disturbances. Treatment with phenylephrine should be discontinued a few days before the planned surgical treatment.
Rauwolfia alkaloids - with simultaneous use may decrease the therapeutic effect of phenylephrine.
Caffeine - with simultaneous use may increase therapeutic and toxic effects of caffeine.
Indomethacin, bromocriptine - in isolated cases with simultaneous use of phenylephrine with indomethacin or bromocriptine, severe arterial hypertension is possible.
Selective serotonin reuptake inhibitors - in case of simultaneous use with antidepressants of this group (fluvoxamine, paroxetine, sertraline), the sensitivity of the organism to sympathomimetics may increase as well as the risk of a serotonergic effect may increase.
Antihypertensive drugs from the group of sympatholytics, such as reserpine, guanethidine - Phenylephrine reduces the hypotensive effect of these drugs.
Chlorphenamine
Alcohol, hypnotic drugs, tranquilizers, antipsychotics (neuroleptics), analgesics of neutral action- Chlorphenamine may enhance the inhibitory effect of these drugs on the central nervous system.
Anticholinergic drugs (atropine, antispasmodics, tricyclic antidepressants, MAO inhibitors, anti-Parkinsonian drugs)- Chlorphenamine enhances the anticholinergic effect of these drugs.
Pregnancy and Lactation
Contraindicated in pregnancy and lactation.
Special instructions
Children and adolescents with diseases accompanied by hyperthermia, it is desirable to prescribe Aspirin only with the ineffectiveness of other drugs. If long-term vomiting occurs when administering Aspirin, this may be a sign of Reye's syndrome.
In patients with allergic diseases, including bronchial asthma, allergic and hay rhinitis, urticaria, pruritus, mucosal edema and nasal polyps, and in combination with chronic infections of the respiratory tract, patients with hypersensitivity to analgesics and antirheumatic drugs of any type may develop bronchial asthma attacks.
During the period of use of the drug should refrain from alcohol.
Overdosage
Symptoms: nausea, vomiting, tinnitus, impairment of hearing and vision, rapid breathing, severe headache, imbalance, severe drowsiness, and heart rhythm disturbances.
Treatment: gastric lavage, the appointment of Activated charcoal, symptomatic therapy.
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