Azelaic acid

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Available since: 2019-09-19

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Clinical Pharmacology

Drug for external use. It has bacteriostatic activity against Propionibacterium acne and Staphylococcus epidermidis, reduces the production of fatty acids that contribute to the occurrence of acne. Reduces the formation of comedones. Influencing the process of keratinization of epidermal cells, inhibits the growth and activity of abnormal melanocytes, causing melasma-type hyperpigmentation. It has an anti-acne, depigmentative effect.

Pharmacokinetics

Suction

After application to the skin penetrates the epidermis and dermis, 3.6% of the total dose is absorbed into the systemic circulation.

Metabolism and excretion

Part of the absorbed acid is excreted by the kidneys in unchanged form, and some - in the form of dicarboxylic acids (C7, C5), formed as a result of beta-oxidation.

Indications

- acne rash (acne vulgaris);

- Rosacea.

Composition

Per 100 g:

azelaic acid in terms of 100% substance 15 g.

Excipients: benzoic acid - 0.1 g, methylpyrrolidone - 4 g, squalane - 1 g, propylene glycol - 8 g, disodium edetate - 0.1 g, sodium hydroxide - 0.25 g, dimethicone 100 cst - 1 g, macrogol cetostearyl ether - 1.4 g, carbomer interpolymer (type A) - 1.4 g, purified water - up to 100 g

Azelaic acid is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Azelik®	Akrikhin	Russia	gel
Skinoren®	Bayer Pharma AG	Germany	cream
Azix-derm®	Ranbaxy Laboratories Ltd	India	cream
Skinoren®	Bayer Pharma AG	Germany	gel

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Dosage and Administration

Apply externally.

The gel should be applied to the previously thoroughly washed (water or cleansed with a mild cleansing cosmetic) and dried face skin. The gel is applied in a thin layer on the affected skin 2 times / day (morning and evening) and lightly rubbed. Approximately 2.5 cm of gel is sufficient for the entire surface of the face.

In patients with acne vulgaris (acne vulgaris), marked improvement is usually observed after 4 weeks. For best results, use of the drug should be continued for several months.

Adverse reactions

On the part of the skin and subcutaneous fat: at the beginning of treatment, local irritating action, hyperemia and peeling of the skin, burning, erythema, itching, usually stopped in the course of treatment, are possible; possible - skin allergic reactions.

Contraindications

- Hypersensitivity to the drug.

The drug should be used with caution during pregnancy and lactation (breastfeeding).

Drug interactions

Can be used in combination with other drugs for the treatment of acne.

Pregnancy and Lactation

During pregnancy and during breastfeeding, they are used only when the intended benefit of therapy for the mother exceeds the risk to the fetus or infant.

Special instructions

In cases of severe irritation of the skin in the first weeks of treatment, the gel can be applied 1 time / day; short-term withdrawal of the drug is also possible. After the disappearance of symptoms of skin irritation should resume regular use of the drug in the recommended dose.

It is necessary to avoid getting the drug in the eyes, as well as on the mucous membranes of the nose, lips and mouth, in case of accidental contact - immediately rinse with water.

During treatment it is necessary to protect the skin from the entire spectrum of solar radiation.

Overdosage

Currently, cases of overdose of the drug is not described.

Brand name: Azelik
Active ingredient: Azelaic acid
Dosage form: Gel for external use 15% white or almost white in color, a slight peculiar smell is allowed.
Manufacturer: Makiz-Pharma