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Baklosan - centrally acting muscle relaxant; GABAB receptor agonist. Reducing the excitability of the terminal parts of afferent sensory fibers and suppressing intermediate neurons, inhibits mono-and polysynaptic transmission of nerve impulses; reduces prestress of muscle spindles. Baklosan does not affect the transmission of impulses in the neuromuscular synapses. In neurological diseases accompanied by skeletal muscle spasticity, it relieves painful spasms and clonic convulsions. Increases the amount of movement in the joints, facilitates the holding of passive and active kinesitherapy (exercise, massage, manual therapy).
Absorption is high. The maximum plasma concentration is reached 2 to 3 hours after taking the drug. Communication with proteins - 30%. Gets through a placental barrier, it is allocated with breast milk. Metabolized in the liver. Excreted by the kidneys (mostly unchanged).
Increased muscle tone in multiple sclerosis; diseases of the spinal cord of infectious, degenerative and traumatic genesis (for example, syringomyelia tumors, motor neuron diseases, injuries); stroke; cerebral palsy; meningitis; traumatic brain injuries; alcoholism (affective disorders).
active substance - baclofen 25 mg;
Excipients - lactose, potato starch, gelatin, talc, magnesium stearate, ethylcellulose.
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Dosage and Administration
Inside, while eating. In the case of skipping the next reception should not take a double dose of the drug.
Adults: initial dose of 5 mg (1/2 pills of 10 mg) 3 times a day. Gradually increase the dose of the drug every 3 days until the onset of the therapeutic effect (usually up to 30 - 75 mg per day). For patients requiring higher doses of Baclofen (from 75 mg to 100 mg per day), the drug should be used in pills of 25 mg. In patients older than 65 years, the dose should be increased with caution due to the increased risk of side effects. The maximum daily dose is 100 mg.
Children: initial dose of 5 mg (1/2 pills of 10 mg) 3 times a day. If necessary, the dose can be carefully increased every 3 days. The following doses are usually recommended: from 1 to 2 years old - 10–20 mg per day, from 2 years to 6 years - 20–30 mg per day, from 6 to 10 years - 30–60 mg per day. In children over 10 years, the maximum dose is 1.5-2.0 mg / kg body weight.
Nausea, vomiting, drowsiness, dizziness, fatigue, dry mouth, confusion, gait disturbance, urinary retention, constipation or diarrhea, lowering blood pressure, apathy; euphoria, depression, paresthesia, myalgia, muscle weakness, ataxia, tremor, nystagmus, accommodation paresis, hallucinations, dysuria, enuresis, convulsions, decrease in seizure threshold. With prolonged use - impaired renal function.
Hypersensitivity, epilepsy, convulsions (in history), psychosis, Parkinson's disease, chronic renal failure, pregnancy and lactation.
With caution in cerebrovascular insufficiency, atherosclerosis of cerebral vessels, gastric ulcer and duodenal ulcer, the elderly and children under 12 years.
Enhances the effect of drugs that affect the central nervous system, antihypertensive drugs, ethanol. Tricyclic antidepressants increase muscle tone reduction; levodopa and cardidopa increase the risk of hallucinations, confusion, agitation. Patients should inform the doctor about all the drugs taken.
In patients with liver disease and diabetes mellitus, it is necessary to periodically monitor the activity of "liver" transaminases, alkaline phosphatase, blood glucose. During treatment, you should refrain from potentially hazardous activities associated with the need for increased attention and quick mental and motor responses.
Symptoms: hypotonia, depression of the respiratory center, confusion, coma (after regaining consciousness, hypotension can persist for 72 hours).
Treatment: excessive drinking, diuretic intake, respiratory depression - mechanical ventilation. There is no specific antidote.
- Brand name: Baklosan
- Active ingredient: Baclofen
- Dosage form: Pills
- Manufacturer: Polpharma
- Country of Origin: Poland
- Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia
- Baclofen infused in rat hippocampal formation impairs spatial learning
- Baclofen reduces GABAA receptor responses in acutely dissociated neurons of bullfrog dorsal root ganglia
- Influence of intrathecal baclofen on silent periods in dystonia
- Chiral analysis of baclofen by α-cyclodextrin-modified capillary electrophoresis and laser-induced fluorescence detection
- Intrathecal baclofen for dystonia: Benefits and complications during six years of experience
- Highly Enantioselective Organocatalytic Conjugate Addition of Nitromethane to α,β-Unsaturated Aldehydes: Three-Step Synthesis of Optically Active Baclofen
- Baclofen in the treatment of staff-man syndrome
- Baclofen as a treatment for nystagmus
- Morbilliform rash secondary to baclofen ingestion
- Effect of baclofen on sleep-related periodic leg movements
- Baclofen in the treatment of trigeminal neuralgia: Double-blind study and long-term follow-up
- Encephalopathy associated with baclofen
- Glossopharyngeal neuralgia: Successful treatment with baclofen
- A controlled clinical trial of baclofen as protective therapy in early huntington's disease
- Baclofen therapy may be associated with chorea in Alzheimer's disease
- Baclofen-induced generalized nonconvulsive status epilepticus
- A double-blind controlled study of gabapentin and baclofen as treatment for acquired nystagmus
- Spectrophotometric Determination of Baclofen.. Spektrophotometrische Bestimmung von Baclofen
- Synthesis and Binding Properties to GABA Receptors of 3-Hydroxypyridinyl- and 3-Hydroxypiperidinyl-Analogues of Baclofen
- Evidence of a specialized transport mechanism for the intestinal absorption of baclofen
- Partially competitive inhibition of intestinal baclofen absorption by beta-alanine, a nonessential dietary aminoacid
- Influence of γ-aminobutyric acid on baclofen intestinal absorption
- Influence of leucine on intestinal baclofen absorption as a model compound of neutral α-aminoacids