Baneocin®
Merck KGaA & Co.
1736 Items
2019-09-19
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Clinical Pharmacology
Baneocin - combined antibacterial drug for external use. Contains two antibiotics that have a bactericidal effect, neomycin and bacitracin.
Bacitracin is a polypeptide antibiotic that inhibits the synthesis of the cell wall of bacteria.
Neomycin is an antibiotic aminoglycoside that inhibits bacterial protein synthesis.
Bacitracin active against gram-positive (Streptococcus spp. / including hemolytic streptococcus /, Staphylococcus spp.) and some gram-negative microorganisms. Resistance to bacitracin is rarely developed. It has good tissue tolerance; inactivation by biological products, blood and tissue components is not observed.
Neomycin active against gram-positive and gram-negative bacteria.
Through the use of a combination of these two antibiotics, a wide spectrum of drug action and synergism of action against a number of microorganisms, for example, staphylococci, is achieved.
Indications
Ointment Baneocin can be used as an additional treatment in the postoperative period:
Applying Baneocin ointment on gauze strips is preferable for the targeted local treatment of patients with infected cavities and wounds (for example, infections of the ear canal, wounds or surgical incisions that heal by secondary tension).
Composition
1 g ointment contains:
Active substances: Zinc-Bacitracin 250 IU, Neomycin sulfate 5000 IU (5 mg).
Baneocin® is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Baneocin® | Merck KGaA & Co | Switzerland | ointment |
| Baneocin® | Merck KGaA & Co | Switzerland | powder |
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Dosage and Administration
Apply the required amount of ointment or powder to the treatment site, if appropriate, under the bandage.
As a rule, in adults and children, Baneocin powder is applied two to four times a day, while Baneocin ointment is used two to three times a day.
In patients with burns occupying more than 20% of the body surface, Baneocin powder should not be used more than once a day, especially in case of a decrease in kidney function, since absorption of the active ingredient may occur.
When applied topically, the dose of neomycin should not exceed 1 g per day (corresponding to 200 g of powder or ointment) for 7 days. When you re-rate the maximum dose should be reduced by half.
Adverse reactions
Allergic reactions: with prolonged use - redness, dry skin, skin rash, itching. When treating chronic dermatoses or chronic otitis media, Baneocin promotes sensitization to other drugs, including neomycin. This can manifest itself in the low efficiency of treatment. Allergic reactions such as contact eczema were less common than usual (associated with cross-allergy to other aminoglycosides in about 50% of cases).
System effects: in case of extensive skin lesions, the possibility of absorption of the drug and the development of oto-and nephrotoxic effects and neuromuscular conduction disorders should be taken into account.
Contraindications
A history of hypersensitivity to bacitracin and / or neomycin, or to other aminoglycoside antibiotics.
Baneocin should not be used for significant skin lesions, as absorption of the drug may cause an ototoxic effect with hearing loss.
Baneocin should not be used in patients with pronounced disorders of the excretory function, including renal etiology, and already having damage to the vestibular and cochlear systems, in cases where uncontrolled absorption of the drug is possible.
Do not use in the ear canal when perforating the eardrum.
Do not apply on eyes.
Drug interactions
If systemic absorption occurs, the concomitant administration of cephalosporins or other aminoglycoside antibiotics may increase the likelihood of a nephrotoxic reaction.
The simultaneous use of diuretics such as ethacrynic acid or furosemide can provoke an oto- and nephrotoxic effect.
The absorption of Baneocin can potentiate the effects of the neuromuscular block in patients receiving drugs, anesthetics and muscle relaxants.
Pregnancy and Lactation
In cases where it is impossible to control the absorption of the drug in pregnant and lactating women, Baneocin should be used with caution. Like all other aminoglycosides, neomycin penetrates the placental barrier. With systemic use of aminoglycosides in a high dose, the development of damage to the cochlear apparatus of the fetus is noted.
Special instructions
When used in doses significantly higher than recommended, due to the possible absorption of Baneocin, attention should be paid to symptoms indicating nephro- and / or ototoxic reactions, especially in patients with trophic ulcers. Since the risk of toxic effects increases with a decrease in liver and / or kidney function, in patients with hepatic and / or renal insufficiency, blood and urine tests should be performed along with an audiometric study before and during intensive therapy with Baneocin.
Precautions should be observed in case of long-term administration of the drug in patients with chronic otitis media due to the possible ototoksicheskogo effect, do not use the drug in the external auditory perforation of the eardrum. If there is an uncontrolled absorption of Baneocin, attention should be paid to the potential block of neuromuscular conduction, especially in patients with acidosis, myasthenia gravis, and other diseases of the neuromuscular apparatus.
With long-term treatment, attention should be paid to the possible growth of resistant microorganisms, especially fungi. In such cases, appropriate treatment should be prescribed.
Patients who have developed allergies and superinfection, the drug should be canceled.
- Brand name: Baneocin
- Active ingredient: Bacitracin, Neomycin
- Dosage form: Ointment for external use
- Manufacturer: Merck KGaA & Co.
- Country of Origin: Switzerland
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