Betahistine

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Available since: 2019-09-19

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Clinical Pharmacology

Betahistine acts mainly on the histamine H1 and H3 receptors of the inner ear and the vestibular nuclei of the CNS. Through direct agonistic action on the H1 receptors of the vessels of the inner ear, as well as indirectly through the impact on the H3 receptors, improves microcirculation and capillary permeability, normalizes the endolymph pressure in the maze and cochlea. However, betahistine increases blood flow in the basilar artery. It has a pronounced central effect, being an inhibitor of the H3 receptors of the nuclei of the vestibular nerve. Improves conductivity in the neurons of the vestibular nuclei at the level of the brain stem. The clinical manifestation of these properties is to reduce the frequency and intensity of dizziness, reduce tinnitus, and improve hearing in case of its decrease.

Pharmacokinetics:

Absorbed quickly, the connection with plasma proteins is low. The maximum concentration in a blood plasma in 3 hours. The half-life in 3-4 hours. Almost completely excreted by the kidneys as a metabolite (2-peridylacetic acid) within 24 hours.

Indications

treatment and prevention of vestibular vertigo of various origin;
syndromes including dizziness and headache, tinnitus, progressive hearing loss, nausea and vomiting;
Meniere's disease or syndrome.

Composition

active substance - betahistine dihydrochloride.

Excipients: microcrystalline cellulose; lactose (milk sugar); lemon acid; colloidal silicon dioxide (aerosil); talc; magnesium stearate; sodium lauryl sulfate; starch 1500 (pregelatinized starch).

Description: tablets 16 mg - white or almost white, flat-cylindrical in shape, with chamfer and risk.

Betahistine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Vertran			pills
Betahistine-SZ	North Star	Russia	pills
Betahistine	Vertex	Russia	pills
Vesticap	Ozon	Russia	capsules
Tagista	Nizhpharm	Russia	pills
Tagista	Hemofarm	Russia	pills
Betahistine	Canonpharma	Russia	pills
Betaver	Veropharm	Russia	pills
Vestibo	Catalent Germani Schorndorf GmbH	Germany	pills
Betaserc	Abbott	USA	pills

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Dosage and Administration

Inside, while eating. 1 / 2-1 pills 3 times a day.

Improvement is usually noted already at the beginning of therapy. A stable therapeutic effect occurs after two weeks of treatment and may increase over several months of treatment. The treatment is long. The duration of the drug is selected individually.

Adverse reactions

Gastrointestinal disorders, allergic reactions of the skin (skin rash, itching, urticaria), angioedema.

Contraindications

Carefully:

peptic ulcer and duodenal ulcer (in history);
pheochromocytoma;
bronchial asthma.

Drug interactions

Cases of interaction or incompatibility with other drugs are unknown.

Pregnancy and Lactation

Not enough data to assess the effects of the drug during pregnancy and lactation. In this regard, it is not recommended reception during pregnancy. At the time of treatment should stop breastfeeding.

Special instructions

Patients with gastric ulcer or duodenal ulcer history, pheochromocytoma or asthma should be prescribed the drug under regular medical supervision.

Influence on ability to drive motor transport and control mechanisms

Betahistine does not have a sedative effect and does not affect the ability to drive a car or engage in activities that require the speed of psychomotor reactions.