Betamethasone, Salicylic Acid

Brand Vertex

In stock 1519 Items

Available since: 2019-09-19

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Clinical Pharmacology

Roderm - a combined preparation for external use, the action of which is due to its constituent components; the drug has anti-inflammatory, antiallergic, antipruritic, keratolytic action. Betamethasone inhibits the release of inflammatory mediators, prevents the regional accumulation of neutrophils, reduces inflammatory exudate and cytokine production, reduces the migration of macrophages, leading to a decrease in the infiltration and granulation processes.
Due to the presence of salicylic acid, it softens the skin, eliminates horny layers and promotes deeper penetration of betamethasone.

Indications

Roderm is indicated for use in the treatment of sub-acute and chronic dermatosis, accompanied by hyperkeratosis and desquamation:
psoriasis, dyshidrotic dermatitis, eczema, neurodermatitis, lichen planus, ichthyosis and ichthyosis of the skin, atopic dermatitis, diffuse neurodermatitis;
simple and allergic dermatitis;
urticaria, erythema multiforme;
simple chronic lichen (limited neurodermatitis).
Dermatosis, not treatable by other glucocorticosteroids (especially red warty), skin dyshidrosis.

Composition

100 g:
- betamethasone dipropionate in terms of betamethasone 0.05 g
- salicylic acid 3.0 g
excipients: liquid paraffin (liquid paraffin), petroleum jelly (white petrolatum, white soft paraffin).

Betamethasone, Salicylic Acid is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Raederm	Vertex	Russia	ointment
Belosalic	Belupo	Croatia
Belosalic	Belupo	Croatia	ointment
Acriderm SK	Akrikhin	Russia	ointment
Diprosalic	Bayer Pharma AG	Germany	ointment

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Dosage and Administration

Topically. Apply on the affected areas at the rate of: a column of Rederm ointment 0.5 cm long on a skin area of approximately 7 cm × 7 cm, slightly rubbing, in a thin layer 2 times a day. Other frequency of use can be set by the doctor based on the severity of the disease. In mild cases, it is enough to apply the ointment, usually once a day; more severe lesions may require more frequent use.
If necessary, impose occlusive dressings that change every 24 hours.
The duration of treatment depends on the effectiveness and tolerability of therapy and is 2-4 weeks.
If clinical improvement does not occur, it is necessary to clarify the diagnosis.

Adverse reactions

- Burning, irritation, dryness, hypopigmentation, itchy skin, folliculitis, hypertrichosis, dermatitis, acne-like rashes.
- When applying occlusive dressings - skin maceration, striae, skin atrophy, secondary infection, prickly heat.
- With prolonged use - atrophy of the skin, local hirsutism, telangiectasia, purpura, hypopigmentation, hypertrichosis.
- When applied to large surfaces - systemic manifestations of side effects of glucocorticosteroids (growth retardation, Itsenko-Cushing syndrome, increased intracranial pressure after treatment, hyperglycemia, glycosuria, hypokalemia, increased blood pressure) or salicylates (pallor, increased fatigue, drowsiness, hyperventilation) background tachypnea, nausea, vomiting, hearing loss, confusion).

Contraindications

Children under 2 years old, lactation period, hypersensitivity, open wounds, bacterial, viral and fungal skin diseases (pyoderma, syphilis, skin tuberculosis, chicken pox, herpes, actinomycosis, blastomycosis, sporotrichosis); post-vaccination skin reactions, perioral dermatitis, rosacea, trophic ulcers against the background of chronic venous insufficiency, skin tumor (skin cancer, nevus, atheroma, epithelioma, melanoma, hemangioma, xanthoma, sarcoma).
Carefully:
Hepatic insufficiency, childhood (over 2 years), long-term therapy, especially with the use of occlusive dressings.

Pregnancy and Lactation

The safety of using local glucocorticosteroids in pregnant women has not been established. The purpose of this group of drugs during pregnancy is justified only if the potential benefit to the mother outweighs the potential risk to the fetus. During pregnancy, this group of drugs should not be used in high doses or for a long time.
It is not established whether topical use of glucocorticosteroids can cause them to appear in mother's milk, therefore, the question of discontinuing breastfeeding should be resolved.

Special instructions

Avoid getting the drug in the eyes, can not be applied to the skin near the eyes and mucous membranes. The drug is not intended for use in ophthalmology. With prolonged treatment, when applying the drug on the vast surface of the skin, using occlusive dressings, systemic absorption of glucocorticosteroids is possible.
Long-term use on the skin of the face is not recommended - it is possible to develop dermatitis like rosacea, perioral dermatitis, skin atrophy and acne; avoid use in the anogenital area.
Rederm Ointment is most suitable for the treatment of patients with dry and fragile skin.
If there are signs of hypersensitivity or skin irritation associated with the use of the drug, discontinue treatment and select adequate therapy for the patient.
With prolonged use of the drug, its cancellation should be carried out gradually.
Pediatric use:
For children from 2 years old, the drug is prescribed only under strict indications and under medical supervision, since it is possible to develop systemic side effects associated with betamethasone. The duration of treatment should be as short as possible.When using the drug Rederm on large surfaces and / or under an occlusive dressing, suppression of the hypothalamic-pituitary-adrenal system and the development of symptoms of hypercorticism may occur, a decrease in growth hormone excretion, an increase in intracranial pressure may be observed.

Overdosage

Acute overdose is unlikely, however, with excessive or prolonged use of the drug, chronic overdose is possible, accompanied by signs of hypercortisolism: hyperglycemia, glycosuria, reversible suppression of the adrenal cortex function, manifestation of Cushing's syndrome.
Treatment.
Corresponding symptomatic treatment is indicated. In the case of chronic toxic effects, a gradual withdrawal of the drug is recommended.