Buy Bromhexin-Akrikhin syrup 4 mg/5 ml 100 ml

Bromhexine

Brand Akrikhin

In stock 725 Items

Available since: 2019-09-19

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Clinical Pharmacology

Bromhexine has mucolytic (secretolytic) and expectorant effects. The mucolytic effect is associated with the depolymerization and liquefaction of mucoprotein and mucopolysaccharide fibers. Bromhexine has a weak antitussive effect. Stimulates the production of endogenous surfactant, ensuring the stability of alveolar cells during respiration. The clinical effect is manifested after 2-5 days from the start of treatment with the drug.

Pharmacokinetics

When ingested, Bromhexine is almost completely (99%) absorbed within 30 minutes. Bioavailability is 20-25% (the effect of "first pass" through the liver). In plasma, Bromhexine strongly binds to proteins of 95%, penetrates the hematoencephalic and placental barriers. In the liver, Bromhexine undergoes demethylation and oxidation. The half-life is 15 hours due to slow reverse diffusion from tissues. Excreted by the kidneys. In chronic renal failure, the release of Bromhexine metabolites is impaired. With repeated use, Bromhexine may accumulate.

Indications

Chronic inflammatory lung diseases (bronchial asthma, cystic fibrosis, tuberculosis, tracheobronchitis, spastic bronchitis, bronchiectasis, pulmonary emphysema, pneumoconiosis), chest injuries, pre- and postoperative period.

Composition

5 ml of syrup contain:

Active substance: Bromhexine hydrochloride - 4 mg.

Bromhexine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Bromhexin-Akrikhin	Akrikhin	Russia	syrup
Bromhexine	Pharmstandard	Russia	pills
Bromhexin-Akrikhin	Akrikhin	Russia	pills
	PFK Obnovlenie	Russia	pills
Bromhexine	Takeda GmbH	Japan	vials
Bromhexine	BPMP	Belarus	pills
Bromhexine	Grindex	Latvia	syrup
Bromhexine	Pharmstandard	Russia	syrup
Bromhexine	Berlin-Chemie/Menarini	Germany	dragee
Bromhexine			mixture

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Dosage and Administration

Bromhexine ingested regardless of the meal.

Adults are prescribed 8-16 mg (10-20 ml) 3-4 times a day.

Children:

from 2 years old - 2 mg (2.5 ml) 2-3 times a day;
from 3 to 6 years - 2-4 mg (2.5-5 ml) 3 times a day;
from 6 to 14 years - 4-8 mg (5-10 ml) 3 times a day.

The course of treatment is from 4 to 28 days.

In the course of treatment, it is recommended to use a sufficient amount of liquid, which supports the secretolytic action of Bromhexine.

In children, treatment should be combined with postural drainage or vibration massage of the chest, which facilitates the evacuation of secretions from the bronchi.

Adverse reactions

From the digestive system: dyspeptic phenomena, transient increase in the activity of liver transaminases in serum.

From the side of the central nervous system: headache, dizziness.

Dermatological reactions: increased sweating, skin rash.

On the part of the respiratory system: cough, bronchospasm.

Contraindications

Pregnancy (I-st trimester), children's age (up to 3 years).

Drug interactions

Bromhexine can be administered simultaneously with other drugs used in the treatment of bronchopulmonary diseases.

Bromhexine is not prescribed simultaneously with antitussives (including those containing codeine), because they may make coughing of sputum diluted with bromhexine difficult.

Bromhexine contributes to the penetration of antibiotics (amoxicillin, erythromycin, cephalexin, oxytetracycline), sulfa drugs into the bronchial secretion in the first 4-5 days of antimicrobial therapy.

Bromhexine is not compatible with alkaline solutions.

Pregnancy and Lactation

During pregnancy and lactation, Bromhexine is used in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.