Buy Migra nol pills 8 pcs
  • Buy Migra nol pills 8 pcs

Caffeine, Paracetamol

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Clinical Pharmacology

Migrenol is a combined analgesic-antipyretic, whose action is determined by the components in its composition.

Paracetamol is a non-narcotic analgesic. It blocks cyclooxygenase (COX) only in the central nervous system (CNS), affecting pain and thermoregulation centers (cellular tissue peroxidase neutralizes the effect of paracetamol on COX in inflammatory tissues), which explains the almost complete absence of anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on the water-salt metabolism (sodium and water retention) and the mucous membrane of the gastrointestinal tract. The possibility of the formation of methemoglobin is unlikely.

Caffeine stimulates the psychomotor centers of the brain, has analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance.



Absorption - high, connection with plasma proteins - 15%. The time to reach maximum concentration (TC max ) - 20-30 min. Penetrates the blood-brain barrier .

Less than 1% of the paracetamol dose taken by the nursing mother passes into breast milk.

A therapeutically effective concentration of paracetamol in plasma is achieved when it is administered at a dose of 10-15 mg / kg.

Metabolized in the liver: 80% react with conjugation with glucuronic acid and sulfates to form inactive metabolites: 17% undergo hydroxylation with the formation of active metabolites, which conjugate with glutathione and form inactive metabolites.

With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis.

The half-life (T 1/2 ) - 2-3 hours

In elderly patients, the clearance of the drug decreases and T increases 1/2 .

Excreted by the kidneys - 3% unchanged.



Vehicle max - caffeine - 1 hour; T 1/2 - 3,5 h; 65-80% of the drug is derived mainly as 1-methylxanthine, 1-methyl uric acid and acetylated uracil derivatives; a small amount is converted to theophylline and theobromine.


Migrenol is used to eliminate the pain syndrome of mild to moderate severity: headache, migraine, toothache, muscle and rheumatic pain, muscle pain, painful menstruation.

Migrenol is also used for the symptomatic treatment of colds and flu to reduce fever.


1 tablet contains acetaminophen (paracetamol) 500 mg and caffeine 65 mg;
Excipients: calcium hydrogen phosphate dihydrate, starch, microcrystalline cellulose, carmellose sodium, magnesium steart, silicon dioxide, Opadry Clear YS-1-7006 (hypromellose + macrogol), carnauba wax, stearic acid.

Caffeine, Paracetamol is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Migrenol Fourcent Ventures USA pills
Migrenium Biochemist Saransk Russia pills
Solpadeine Tamar S.A Greece pills

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Caffeine, Paracetamol

Dosage and Administration

take Migrenol pills by mouth, usually 1-2 pills, if necessary 3-4 times a day. The interval between doses - at least 4 hours. The maximum single dose - 2 pills, the maximum daily dose - 8 pills.

The drug is not recommended to use without the appointment and observation of a doctor for more than 5 days when used as an anesthetic and for more than 3 days as an antipyretic.

Do not exceed the specified dose. In case of overdose, you should immediately consult a doctor.

Adverse reactions

Allergic reactions (skin rash, pruritus, urticaria, angioedema), multifactorial exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Leila syndrome), dizziness, nausea, epigastric pain; hemolytic anemia, thrombocytopenia, agranulocytosis; insomnia.

With prolonged use in large doses - hepatotoxic effect, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia; nephrotoxicity.


Should be taken with care if used for Gilbert's syndrome and other benign hyperbilirubinemia, glaucoma, sleep disorders.

Drug interactions

When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.

Inductors of microsomal oxidation of the liver (barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the risk of hepatotoxic action with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic action.

Under the influence of paracetamol, the time of chloramphenicol excretion is increased 5 times.

Caffeine accelerates the absorption of ergotamine.

Simultaneous intake of paracetamol and alcohol increases the risk of hepatotoxic effects and acute pancreatitis.

Metoclopramide and domperidone increase, and Kolestiramin reduces the rate of absorption of paracetamol.

The drug can reduce the effectiveness of uricosuric drugs.

Enhances the action of monoamine oxidase inhibitors.

Pregnancy and Lactation


Special instructions

Excessive consumption of caffeine-containing products (coffee, tea) during treatment may cause overdose symptoms. During treatment, avoid work that requires quick reaction and concentration, do not use alcohol and other means of inhibiting the central nervous system.

During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver.

Influence on ability to drive motor transport and control mechanisms

During treatment, avoid work that requires quick reaction and concentration.


Symptoms: nausea, vomiting, stomach pain, pallor of the skin, anorexia. Hepatonecrosis (the severity of necrosis due to intoxication directly depends on the degree of overdose), the developed clinical picture of liver damage appears after 1-6 days.

Treatment: gastric lavage and adsorbents (Activated charcoal). If you suspect an overdose, you should immediately seek medical help.

  • Brand name: Migra nol
  • Active ingredient: Caffeine, Paracetamol
  • Dosage form: Migrenol. Coated pills.
  • Manufacturer: Fourcent Ventures
  • Country of Origin: USA

Studies and clinical trials of Caffeine, Paracetamol (Click to expand)

  1. A Simple Strategy for Simultaneous Determination of Paracetamol and Caffeine Using Flow Injection Analysis with Multiple Pulse Amperometric Detection
  2. Carcinogenicity of analgesics: Long-term treatment of sprague-dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen)
  3. Sequential injection chromatographic determination of paracetamol, caffeine, and acetylsalicylic acid in pharmaceutical tablets
  4. Determination of Paracetamol in the Presence of Caffeine and Acetylsalicylic Acid in Analgesic Formulations by the Linear Absorbances Method and the Derivative Spectroscopy Technique
  5. Simultaneous quantitation of paracetamol, caffeine and propyphenazone by high-pressure liquid chromatography
  6. Simultaneous determination of propyphenazone, paracetamol and caffeine in blood by high-performance liquid chromatography
  7. Mixed ion pair liquid chromatography method for the simultaneous assay of ascorbic acid, caffeine, chlorpheniramine maleate, dextromethorphan HBr monohydrate and paracetamol in Frenadol™ sachets
  8. Simultaneous assay of phenylpropanolamine hydrochloride, caffeine, paracetamol, glycerylguaiacolate and chlorpheniramine maleate in Silabat™ tablet using HPLC with diode array detection
  9. Simultaneous determination of acetylsalicylic acid, paracetamol and caffeine using solid-phase molecular fluorescence and parallel factor analysis
  10. N-way PLS applied to simultaneous spectrophotometric determination of acetylsalicylic acid, paracetamol and caffeine
  11. Simultaneous determination of paracetamol, caffeine and propyphenazone in ternary mixtures by micellar electrokinetic capillary chromatography
  12. Multivariate analysis of paracetamol, propiphenazone, caffeine and thiamine in quaternary mixtures by PCR, PLS and ANN calibrations applied on wavelet transform data
  13. Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography–tandem mass spectrometry
  14. Simultaneous spectrophotometric determination of paracetamol, ibuprofen and caffeine in pharmaceuticals by chemometric methods
  15. Application of a new spectrophotometric method for the analysis of a ternary mixture containing metamizol, paracetamol and caffeine in tablets
  16. Derivative ratio spectra–zero crossing spectrophotometry and LC method applied to the quantitative determination of paracetamol, propyphenazone and caffeine in ternary mixtures
  17. LC method for the analysis of paracetamol, caffeine and codeine phosphate in pharmaceutical preparations
  18. Linear regression analysis and its application to the multivariate spectral calibrations for the multiresolution of a ternary mixture of caffeine, paracetamol and metamizol in tablets
  19. Erratum to “Linear regression analysis and its application to the multivariate spectral calibrations for the multiresolution of a ternary mixture of caffeine, paracetamol and metamizol in tablets”: [Journal of Pharmaceutical and Biomedical Analysis 33 (2003) 605–615]
  20. A comparative study of the ratio spectra derivative spectrophotometry, Vierordt’s method and high-performance liquid chromatography applied to the simultaneous analysis of caffeine and paracetamol in tablets
  21. Simultaneous determination of paracetamol, caffeine and acetylsalicylic acid by means of a FI ultraviolet pls multioptosensing device
  22. The simultaneous determination of caffeine, aspirin and paracetamol by principal components regression using automatic dilution and calibration
  23. Treatment of fibromyalgia (Fibrositis syndrome): A parallel double blind trial with carisoprodol, paracetamol and caffeïne (Somadril comp®) versus placebo
  24. PLS-UV spectrophotometric method for the simultaneous determination of paracetamol, acetylsalicylic acid and caffeine in pharmaceutical formulations

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