Caffeine, Paracetamol

Brand Fourcent Ventures

In stock 1951 Items

Available since: 2019-09-19

Dosage form

pills

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Package Size

8 pcs

$24.69

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Clinical Pharmacology

Migrenol is a combined analgesic-antipyretic, whose action is determined by the components in its composition.

Paracetamol is a non-narcotic analgesic. It blocks cyclooxygenase (COX) only in the central nervous system (CNS), affecting pain and thermoregulation centers (cellular tissue peroxidase neutralizes the effect of paracetamol on COX in inflammatory tissues), which explains the almost complete absence of anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on the water-salt metabolism (sodium and water retention) and the mucous membrane of the gastrointestinal tract. The possibility of the formation of methemoglobin is unlikely.

Caffeine stimulates the psychomotor centers of the brain, has analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance.

Pharmacokinetics

Paracetamol

Absorption - high, connection with plasma proteins - 15%. The time to reach maximum concentration (TC _max ) - 20-30 min. Penetrates the blood-brain barrier .

Less than 1% of the paracetamol dose taken by the nursing mother passes into breast milk.

A therapeutically effective concentration of paracetamol in plasma is achieved when it is administered at a dose of 10-15 mg / kg.

Metabolized in the liver: 80% react with conjugation with glucuronic acid and sulfates to form inactive metabolites: 17% undergo hydroxylation with the formation of active metabolites, which conjugate with glutathione and form inactive metabolites.

With a lack of glutathione, these metabolites can block the enzyme systems of hepatocytes and cause their necrosis.

The half-life (T _1/2 ) - 2-3 hours

In elderly patients, the clearance of the drug decreases and T increases _1/2 .

Excreted by the kidneys - 3% unchanged.

Caffeine

Vehicle _max - caffeine - 1 hour; T _1/2 - 3,5 h; 65-80% of the drug is derived mainly as 1-methylxanthine, 1-methyl uric acid and acetylated uracil derivatives; a small amount is converted to theophylline and theobromine.

Indications

Migrenol is used to eliminate the pain syndrome of mild to moderate severity: headache, migraine, toothache, muscle and rheumatic pain, muscle pain, painful menstruation.

Migrenol is also used for the symptomatic treatment of colds and flu to reduce fever.

Composition

1 tablet contains acetaminophen (paracetamol) 500 mg and caffeine 65 mg;
Excipients: calcium hydrogen phosphate dihydrate, starch, microcrystalline cellulose, carmellose sodium, magnesium steart, silicon dioxide, Opadry Clear YS-1-7006 (hypromellose + macrogol), carnauba wax, stearic acid.

Caffeine, Paracetamol is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Migrenol	Fourcent Ventures	USA	pills
Migrenium	Biochemist Saransk	Russia	pills
Solpadeine	Tamar S.A	Greece	pills

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Dosage and Administration

take Migrenol pills by mouth, usually 1-2 pills, if necessary 3-4 times a day. The interval between doses - at least 4 hours. The maximum single dose - 2 pills, the maximum daily dose - 8 pills.

The drug is not recommended to use without the appointment and observation of a doctor for more than 5 days when used as an anesthetic and for more than 3 days as an antipyretic.

Do not exceed the specified dose. In case of overdose, you should immediately consult a doctor.

Adverse reactions

Allergic reactions (skin rash, pruritus, urticaria, angioedema), multifactorial exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Leila syndrome), dizziness, nausea, epigastric pain; hemolytic anemia, thrombocytopenia, agranulocytosis; insomnia.

With prolonged use in large doses - hepatotoxic effect, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia; nephrotoxicity.

Contraindications

Should be taken with care if used for Gilbert's syndrome and other benign hyperbilirubinemia, glaucoma, sleep disorders.

Drug interactions

When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.

Inductors of microsomal oxidation of the liver (barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the risk of hepatotoxic action with small overdoses.

Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic action.

Under the influence of paracetamol, the time of chloramphenicol excretion is increased 5 times.

Caffeine accelerates the absorption of ergotamine.

Simultaneous intake of paracetamol and alcohol increases the risk of hepatotoxic effects and acute pancreatitis.

Metoclopramide and domperidone increase, and Kolestiramin reduces the rate of absorption of paracetamol.

The drug can reduce the effectiveness of uricosuric drugs.

Enhances the action of monoamine oxidase inhibitors.

Pregnancy and Lactation

Contraindicated.

Special instructions

Excessive consumption of caffeine-containing products (coffee, tea) during treatment may cause overdose symptoms. During treatment, avoid work that requires quick reaction and concentration, do not use alcohol and other means of inhibiting the central nervous system.

During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver.

Influence on ability to drive motor transport and control mechanisms

During treatment, avoid work that requires quick reaction and concentration.

Overdosage

Symptoms: nausea, vomiting, stomach pain, pallor of the skin, anorexia. Hepatonecrosis (the severity of necrosis due to intoxication directly depends on the degree of overdose), the developed clinical picture of liver damage appears after 1-6 days.

Treatment: gastric lavage and adsorbents (Activated charcoal). If you suspect an overdose, you should immediately seek medical help.