Calcemin®
Bayer Pharma AG
895 Items
2019-09-19
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Clinical Pharmacology
The combined preparation containing vitamin DZ, micro and macrocells. It regulates calcium and phosphorus metabolism, compensates for the relative deficiency of trace elements and vitamin DZ, prevents diseases of the musculoskeletal system, and strengthens the skeletal system and joints.
Calcium, which is part of the drug, is a building component for bone tissue, regulates vascular wall permeability, participates in the regulation of conductivity in synapses and neuro-muscular compounds, participates in the contractile activity of skeletal and smooth muscles, is a necessary component for blood coagulation. Calcium is represented in the preparation of carbonate and citrate salts. Calcium carbonate contains the maximum amount of elemental calcium. Calcium citrate reduces the dependence of the process of calcium bioavailability on the state of the mucous membrane of the gastrointestinal tract, prevents the formation of stones in the urinary system even in case of prolonged use, reduces the excess production of parathyroid hormone.
Vitamin D (cholecalciferol) promotes adequate absorption of calcium, is involved in the processes of regeneration and the construction of bone tissue.
Zinc is a component of various body enzymes (more than 200 species) that synthesize proteins and nucleic acids. It also provides gene expression, regeneration and cell growth. A positive effect on the activity of the enzyme alkaline phosphatase.
Manganese promotes the synthesis of substances that are components of bone and cartilage tissue (glycosaminoglycans). Potentiates calcium-sparing ability of vitamin D.
Copper is involved in the formation of elastin, collagen. It helps to stop the phenomenon of demineralization of bone structures.
Boron normalizes the activity of parathyroid hormone - parathyroid hormone. The latter is involved in the metabolism of calcium, cholecalciferol, phosphorus, magnesium. The effect on mineral metabolism of parathyroid hormone does not depend on the intake of vitamin D3.
Indications
- Prevention and complex treatment of osteoporosis of various origins:
- To compensate for calcium deficiency and trace elements in adolescents, in women during pregnancy and breastfeeding.
Composition
Active ingredients:
Calcium 250 mg (calcium citrate and calcium carbonate), Vitamin D3 (cholecalciferol) 50 ME, copper (copper oxide) 0.5 mg, zinc (zinc oxide) 2 mg, manganese (manganese sulfate) 0.5 mg, boron (sodium borate) 50 mcg.
Inactive Ingredients:
Maltodextrin, microcrystalline cellulose, croscalous sodium, acacia, stearic acid, soy polysaccharide, magnesium stearate.
Shell:
Hypromellose 11, 71, triacetin 2, 53 mg, mineral oil 1, 27 mg, sodium lauryl sulfate 0, 004 mg, 7, 03 mg, magnesium silicate 5 mg.
Description:
pills biconvex oval-shaped, coated white in white with a risk on one side.
Calcemin® is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Calcemin | Bayer Pharma AG | Germany | pills |
| Calcemin Advance | Bayer Pharma AG | Germany | pills |
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Dosage and Administration
Orally
Children from 5 to 12 years old take 1 tab. 1 time per day with meals.
Adults and children over 12 years old - 1 tablet 2 times a day with meals.
During the period of pregnancy and breastfeeding: from the 20th week of pregnancy and the entire period of breastfeeding - 1 tablet 2 times a day.
The minimum course of taking the drug for treating osteoporosis as part of complex therapy for adults is 3 months, a longer course - after consulting a doctor.
The minimum course of taking the drug for the prevention of osteoporosis for adults is 1 month, a longer course - after consulting a doctor.
The minimum course of taking the drug for children and adults with calcium deficiency and trace elements is 2-3 months, a longer course - after consulting a doctor.
A repeated course of the drug is possible 1 month after the end of treatment.
Adverse reactions
Nausea, vomiting, flatulence, diarrhea, constipation, hypercalcemia, hypercalciuria, allergic reactions (itching, rash, urticaria).
Increased individual sensitivity to any of the components of the drug, hypercalcemia and hypercalciuria, nephroltiasis, vitamin D3 hypervitaminosis, severe renal failure, active tuberculosis, decalcifying swelling (myeloma, bone metastases, sarcoidosis), children up to 5 years.
Carefully:
Benign granulomatosis, taking cardiac glycosides and thiazide diuretics, pregnancy, lactation.
Drug interactions
With simultaneous use of the drug Kaltsemin with vitamin A reduces the toxicity of vitamin D3. Phenytoin, barbiturates, GCS reduce the effectiveness of vitamin D3. Laxatives reduce the absorption of vitamin D3. GCS, hormonal contraceptives for systemic use, levothyroxine worsen the absorption of calcium ions. With simultaneous use of tetracyclines, the interval between doses should be at least 3 hours, bisphosphonates and sodium fluoride (their absorption is disturbed) - at least 2 hours. When combined with Calcemin with cardiac glycosides, their toxicity increases (ECG and clinical condition monitoring is necessary), thiazide diuretics - increases the risk of hypercalcemia, with furosemide and other loop diuretics - increases the excretion of calcium by the kidneys. Do not use Calcemin simultaneously with calcium channel blockers. The combined use of the drug with antacids containing aluminum due to a decrease in their effectiveness is not recommended.
Pregnancy and Lactation
During pregnancy and breastfeeding, the drug should be coordinated with the doctor.
the dose should not exceed 1500 mg of calcium and 600 IU of vitamin D3, hypergalcemia that develops on the background of an overdose during pregnancy can cause defects of mental and physical development in the fetus.
In lactating women, it should be borne in mind that colecalciferol and its metabolites pass into breast milk, therefore it is necessary to take into account the intake of calcium and vitamin D3.
Special instructions
The dose should not exceed that specified in the instructions, since increased calcium intake may inhibit the absorption in the intestines of iron, zinc and other essential minerals.
Overdosage
Vitamin D hypervitaminosis, hypercalcemia and hypercalciuria. Symptoms: loss of appetite, thirst, polyuria, dizziness, fainting, constipation, nausea and vomiting. With prolonged use of excessive doses of calcification of the joints and tissues. It is necessary to reduce the dose or stop using the drug. In case of accidental overdose, it is necessary to induce vomiting, flush the stomach. Symptomatic therapy.
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