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The combined preparation containing vitamin DZ, micro and macrocells. It regulates calcium and phosphorus metabolism, compensates for the relative deficiency of trace elements and vitamin DZ, prevents diseases of the musculoskeletal system, and strengthens the skeletal system and joints.
Calcium, which is part of the drug, is a building component for bone tissue, regulates vascular wall permeability, participates in the regulation of conductivity in synapses and neuro-muscular compounds, participates in the contractile activity of skeletal and smooth muscles, is a necessary component for blood coagulation. Calcium is represented in the preparation of carbonate and citrate salts. Calcium carbonate contains the maximum amount of elemental calcium. Calcium citrate reduces the dependence of the process of calcium bioavailability on the state of the mucous membrane of the gastrointestinal tract, prevents the formation of stones in the urinary system even in case of prolonged use, reduces the excess production of parathyroid hormone.
Vitamin D (cholecalciferol) promotes adequate absorption of calcium, is involved in the processes of regeneration and the construction of bone tissue.
Zinc is a component of various body enzymes (more than 200 species) that synthesize proteins and nucleic acids. It also provides gene expression, regeneration and cell growth. A positive effect on the activity of the enzyme alkaline phosphatase.
Manganese promotes the synthesis of substances that are components of bone and cartilage tissue (glycosaminoglycans). Potentiates calcium-sparing ability of vitamin D.
Copper is involved in the formation of elastin, collagen. It helps to stop the phenomenon of demineralization of bone structures.
Boron normalizes the activity of parathyroid hormone - parathyroid hormone. The latter is involved in the metabolism of calcium, cholecalciferol, phosphorus, magnesium. The effect on mineral metabolism of parathyroid hormone does not depend on the intake of vitamin D3.
- Prevention and complex treatment of osteoporosis of various origins:
- To compensate for calcium deficiency and trace elements in adolescents, in women during pregnancy and breastfeeding.
Calcium 250 mg (calcium citrate and calcium carbonate), Vitamin D3 (cholecalciferol) 50 ME, copper (copper oxide) 0.5 mg, zinc (zinc oxide) 2 mg, manganese (manganese sulfate) 0.5 mg, boron (sodium borate) 50 mcg.
Maltodextrin, microcrystalline cellulose, croscalous sodium, acacia, stearic acid, soy polysaccharide, magnesium stearate.
Hypromellose 11, 71, triacetin 2, 53 mg, mineral oil 1, 27 mg, sodium lauryl sulfate 0, 004 mg, 7, 03 mg, magnesium silicate 5 mg.
pills biconvex oval-shaped, coated white in white with a risk on one side.
Calcemin® is marketed under different brands and generic names, and comes in different dosage forms:
|Brand name||Manufacturer||Country||Dosage form|
|Calcemin||Bayer Pharma AG||Germany||pills|
|Calcemin Advance||Bayer Pharma AG||Germany||pills|
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Dosage and Administration
I take Migrenol pills by mouth, usually 1-2 pills, if necessary 3-4 times a day. The interval between doses - at least 4 hours. The maximum single dose - 2 pills, the maximum daily dose - 8 pills.
The drug is not recommended to use without the appointment and observation of a doctor for more than 5 days when used as an anesthetic and for more than 3 days as an antipyretic.
Do not exceed the specified dose. In case of overdose, you should immediately consult a doctor.
Allergic reactions (skin rash, pruritus, urticaria, angioedema), multifactorial exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Leila syndrome), dizziness, nausea, epigastric pain; hemolytic anemia, thrombocytopenia, agranulocytosis; insomnia.
With prolonged use in large doses - hepatotoxic effect, hemolytic anemia, aplastic anemia, methemoglobinemia, pancytopenia; nephrotoxicity.
Carefully should be used for Gilbert's syndrome and other benign hyperbilirubinemia, glaucoma, sleep disorders.
When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.
Inductors of microsomal oxidation of the liver (barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants) increase the risk of hepatotoxic action with small overdoses.
Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic action.
Under the influence of paracetamol, the time of chloramphenicol excretion is increased 5 times.
Caffeine accelerates the absorption of ergotamine.
Simultaneous intake of paracetamol and alcohol increases the risk of hepatotoxic effects and acute pancreatitis.
Metoclopramide and domperidone increase, and Kolestiramin reduces the rate of absorption of paracetamol.
The drug can reduce the effectiveness of uricosuric drugs.
Enhances the action of monoamine oxidase inhibitors.
Pregnancy and Lactation
Excessive consumption of caffeine-containing products (coffee, tea) during treatment may cause overdose symptoms. During treatment, avoid work that requires quick reaction and concentration, do not use alcohol and other means of inhibiting the central nervous system.
During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver.
Influence on ability to drive motor transport and control mechanisms
During treatment, avoid work that requires quick reaction and concentration.
Symptoms: nausea, vomiting, stomach pain, pallor of the skin, anorexia. Hepatonecrosis (the severity of necrosis due to intoxication directly depends on the degree of overdose), the developed clinical picture of liver damage appears after 1-6 days.
Treatment: gastric lavage and adsorbents (Activated charcoal). If you suspect an overdose, you should immediately seek medical help.
- Brand name: Migra nol
- Active ingredient: Caffeine, Paracetamol
- Dosage form: Migrenol. Coated pills.
- Manufacturer: Fourcent Ventures
- Country of Origin: USA