Buy Caposide pills 50 mg + 25 mg 28 pcs
  • Buy Caposide pills 50 mg + 25 mg 28 pcs

Capozide®

Akrikhin
1552 Items
2019-09-19
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$38.56
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Clinical Pharmacology

Caposide has a hypotensive effect. Inhibits ACE; inhibits the formation of angiotensin II, interferes with its vasoconstrictor action and stimulates aldosterone secretion in the adrenal glands, increases the excretion of sodium, chlorine and water from the body.

Indications

Arterial hypertension.

Composition

1 tablet contains captopril 50 mg and hydrochlorothiazide 25 mg.

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Capozide®

Dosage and Administration

Caposide is taken orally, regardless of the meal. Begin with 1/2 tab., Increasing the dose to 1 tab. 1 time per day (maintenance dose).

Adverse reactions

Since the cardiovascular system: "flushes" of blood to the skin of the face, fever, dizziness: headache; tachycardia; heartbeat; swelling of the legs; pronounced decrease in blood pressure (including orthostatic) with symptoms of dizziness, feeling of weakness, in rare cases, fainting, tachycardia; heartbeat; with a sharp or prolonged excessive decrease in blood pressure - transient violation of cerebral circulation; stroke; myocardial infarction.
From the water and electrolyte exchange:violations of water and electrolyte balance: dry mouth, thirst, fatigue, depression, drowsiness, weakness. In rare cases - reduced formation of tear fluid.
On the part of the respiratory system: bronchospasm, dry cough; in rare cases - respiratory failure, sinusitis, rhinitis, laryngitis.
Allergic reactions: angioedema of the larynx, pharynx and / or tongue; allergic reactions (up to the development of pulmonary edema), skin rash (rash, in rare cases - urticaria).
Dermatological reactions: exfoliative dermatitis, erythema multiforme exudative (including Stevens-Johnson syndrome), and toxic epidermal necrolysis (Lyell's syndrome). These skin changes may be accompanied by a rise in body temperature, pain in muscles and joints, and development of vasculitis. In some cases, skin changes resembling psoriasis, photosensitivity, hair loss, nail disorders (onycholysis).
From the digestive system: nausea, vomiting, constipation or diarrhea, stomach discomfort, abdominal pain, loss of appetite, acute cholecystitis (with cholelithiasis), hemorrhagic pancreatitis, hepatitis, cholestatic jaundice, increased activity of liver enzymes, hyperbilirubinemia. With prolonged use: gingival hyperplasia, asthenia, change in taste, renal dysfunction, nephritis. From the central and peripheral nervous system: headache, fatigue, in rare cases - depression, depression, sleep disturbances, reduced potency, convulsions; imbalance, dizziness, tinnitus, visual impairment, progression of myopia, tremor, paresthesia, taste disturbances.
From the hemopoietic system:anemia, decrease in hematocrit, thrombocytopenia, leukopenia, neutropenia (up to the development of pancytopenia and agranulocytosis - especially against the background of simultaneous use of allopurinol, procainamide, as well as immunosuppressants), eosinophilia, an increase in anti-nuclear antibody titer.
From the urinary system:proteinuria; in rare cases, especially in patients with renal insufficiency, there may be an increase in serum concentration of urea, creatinine and potassium ions (the risk of hyperkalemia is also increased in patients with diabetes mellitus), as well as hyponatremia.
Metabolism:hyperlipidemia, hyperglycemia; hyperuricemia (up to exacerbation of gout).

Contraindications

Hypersensitivity to captopril, diuretic preparations of the thiazide type, sulfonamides; tendency to tissue hydration (angioedema, including as a result of previous treatment with ACE inhibitors); renal dysfunction (serum creatinine more than 1.8 mg / 100 ml or creatinine Cl less than 30 ml / min), acute inflammation in the kidneys, renal artery stenosis (bilateral or unilateral in the case of one kidney), condition after kidney transplantation; aortic or mitral valve stenosis, disorders affecting cardiac output (for example, hypertrophic cardiomyopathy); severe abnormal liver function (precomatose state, hepatic coma); primary increase in aldosterone concentration in the blood, hypokalemia, hyponatremia with hypovolemia, hypercalcemia, gout.

Drug interactions

Capozide increases the concentration of digoxin in the blood plasma by 15-20%, increases the bioavailability of propranopol.
The risk of developing an immunosuppressive effect increases with combined use with procainamide, as well as drugs that block tubular secretion (decrease in the number of leukocytes and granulocytes).
Increases the neurotoxicity of salicylates, the action of muscle relaxants of a competitive type of action, ethanol.
Reduces the excretion of quinidine, the action of oral hypoglycemic drugs (drugs), norepinephrine, epinephrine and anti-gouty drugs.
Strengthens the side effects of cardiac glycosides, especially when administered concurrently with drugs that increase the excretion of potassium and magnesium ions and / or retain calcium ions (for example, diuretics, adrenal cortex hormones, laxatives, amphotericin B, carbenoxolone, penicillin G, salicylates).
Cimetidine, slowing down the metabolism of captopril in the liver, increases its plasma concentration.
The combination with nitrates, thiazide diuretics, verapamil, beta-blockers and other antihypertensive drugs, as well as tricyclic antidepressants, hypnotics and ethanol increases the severity of the hypotensive effect.
With simultaneous appointment with lithium preparations, there may be a slowdown in the elimination of lithium ions (an increase in the damaging effect on the heart and central nervous system).
Drugs that bind intensively to proteins enhance the diuretic effect.
At the same time taking methyldopa may develop hemolysis of red blood cells.
Kolestiramin reduces the absorption of Capozide.
Table salt and nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the severity of the hypotensive action.
Potassium salts, potassium-sparing diuretics and heparin contribute to the development of hyperkalemia.
The purpose of Capozide on the background of hemodialysis using certain dialysis membranes of high permeability (for example, polyacrylonitrile-metalyl sulfonate membranes) increases the risk of allergic reactions (anaphylatoid reactions).

Pregnancy and Lactation

Not recommended.

Special instructions

At the beginning of treatment, an excessive decrease in blood pressure may be observed, especially in patients with chronic heart failure, severe hypertension (including kidney origin) and / or kidney failure.

Before starting treatment, it is necessary to compensate for the deficiency of sodium ions and BCC (reduce the dose of previously prescribed diuretics or, in some cases, completely cancel them), as well as determine the indicators of kidney function.

Requires regular monitoring of plasma concentrations of potassium and calcium ions (especially in patients receiving treatment with digitalis, glucocorticosteroids (GCS), often using laxatives, as well as in elderly patients), glucose, uric acid, lipids (cholesterol and triglycerides (TG)) , urea and creatinine, activity of "liver" enzymes.

Especially careful monitoring of blood pressure levels and laboratory parameters is necessary in the following cases: in patients with renal insufficiency; patients with severe arterial hypertension (including kidney genesis); in elderly patients (over 65 years); in patients with impaired water and electrolyte balance and decompensated CHF; as well as receiving simultaneously allopurinol, lithium salts, procainamide, and drugs that reduce immunity.

When fever, swollen lymph nodes and / or signs of laryngitis and / or pharyngitis appear, the number of leukocytes should be immediately determined.

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed.

Overdosage

Possible increased severity of side effects.
Treatment: symptomatic therapy.

  • Brand name: Caposide
  • Active ingredient: Hydrochlorothiazide, Captopril
  • Dosage form: Pills.
  • Manufacturer: Akrikhin
  • Country of Origin: Russia

Studies and clinical trials of Capozide (Click to expand)

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