Carbocysteine

Brand A.Nattermann and Cie GmbH

In stock 1522 Items

Available since: 2019-09-19

Dosage form

syrup
capsules
tea bags

Brand & Manufacturer

Package Size

50 mg/ml 125 ml
20 mg/ml 125 ml

$56.81

Quantity

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Clinical Pharmacology

Libexin Muko - mucolytic.

Pharmacodynamics

Carbocysteine, being a mucolytic, has an effect on the gel phase of the endobronchial secretion, breaking the disulfide bridges of glycoproteins and, thus, reducing the viscosity and increasing the elasticity of the secretion.

Carbocysteine activates sialic transferase - the enzyme of the bronchial mucous membrane goblet cells, normalizes the quantitative ratio of acidic and neutral sialomucins, promotes the regeneration of the mucous membrane, normalizes its structure, activates the activity of the ciliary epithelium, restores the secretion of immunologically active IgA (specific protection), improves

Pharmacokinetics

Carbocysteine is rapidly absorbed after ingestion, reaching C_max in serum after 2 hours. Bioavailability is low (less than 10% of the dose taken) as a result of possible rapid passage through the liver. T_1/2 - About 2 hours. It is excreted mainly by the kidneys along with metabolites.

Indications

Acute and chronic bronchopulmonary diseases, accompanied by the formation of viscous, difficult to separate sputum (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis) and mucus (inflammatory diseases of the middle ear, nose and sinuses - rhinitis, otitis media, sinusitis); preparing the patient for bronchoscopy or bronchography.

Composition

100 ml of syrup contains:

Active ingredient: carbocysteine2 g;

Excipients: sucrose - 70 g; methyl parahydroxybenzoate - 0.15 g; vanillin - 0.05 g; Ponso 4R crimson dye (cochineal red A - E124) - 0.005 g; raspberry flavoring - 1 ml; cherry flavoring - 0.5 ml; sodium hydroxide - q.s. to a pH of 6.1–6.3; purified water - up to 100 ml.

Carbocysteine is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Libexin Muco	A.Nattermann and Cie GmbH	Germany	syrup
Bronchobos	Bosnalek	Bosnia and Herzegovina	capsules
Bronchobos	Bosnalek	Bosnia and Herzegovina	syrup
Fluifort	Dompe	Italy	tea bags
Fluifort	Dompe	Italy	syrup
Fluditec	Innotech International	France	syrup

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Dosage and Administration

For oral use

One measuring cup of syrup (15 ml) contains 750 mg of carbocysteine, 1 measuring spoon (5 ml) - 100 mg of carbocysteine.

For adults- one measuring cup (15 ml) 3 times a day, preferably separately from meals;children 2–5 years old - on 1 measured spoon 2 times a day (200 mg / days),older than 5 years- 1 scoop 3 times a day (300 mg / day).

The duration of treatment without consulting a doctor should not exceed 8 days.

Adverse reactions

On the part of the digestive tract: sometimes nausea, vomiting, diarrhea, epigastric pain, gastrointestinal bleeding.

On the part of the immune system: allergic skin rash and anaphylactic reactions, including urticaria, angioedema, exanthema, persistent erythema.

Skin and Subcutaneous Tissues: isolated cases of bullous dermatitis, including Stevens-Johnson syndrome and erythema multiforme (exudative).

Allergic reactions: itching, urticaria, rash, angioedema.

Other: dizziness, weakness, malaise.

Carefully: gastric ulcer and duodenal ulcer history, lactation.

Drug interactions

Karbotsistein increases the effectiveness of corticosteroids and antibacterial therapy of inflammatory diseases of the upper and lower respiratory tract, potentiates the bronchodilator effect of theophylline. The activity of carbocysteine is weakened by antitussive and atropine-like agents.

Due to the alcohol content Libexin Muko^® (for adults) is prescribed with caution with the following drugs: drugs that cause adverse reactions (fever, redness, vomiting, tachycardia) while being taken with alcoholic beverages - disulfiram, cefamandol, cefoperazone, latamoxfef (cephalosporin antibiotics), chloramphenicol (opfimol) (fylenomer) chlorpropamide, glibenclamide, glipizide, tolbutamide (sulfamide antidiabetic drugs), griseofulvin (antifungal drug), nitro-5-imidazoles (metronidazole, ornidazole, secnidazole, tinidazole), ketoconazole, pro carbazine (cytostatic); drugs that depress the central nervous system.

Special instructions

Alcohol content in Libexin Mucco^® (for adults) is 1.64% by volume, i.e. 0.2 g of alcohol in a measuring cup. It can be dangerous for people with liver diseases, alcoholism, epilepsy, injuries or diseases of the brain, pregnant women.

When appointing Liebeksina Muko^® patients with diabetes mellitus or patients on a low-carb diet should take into account the sucrose content - 6 g per measuring cup of syrup for adults or 3.5 g per measuring spoon of syrup for children.

When patients follow a salt-free or low-salt diet, the sodium content (97 mg) per measuring cup should be taken into account.

Influence on the ability to drive a car or perform work that requires increased speed of physical and mental reactions. Violation of the speed of psychomotor reactions associated with the presence of alcohol in the preparation may be dangerous when driving a car or working with mechanisms.