Cernilton®
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Clinical Pharmacology
Cernilton Forte is a remedy for the treatment of diseases of the prostate gland of plant origin.
Cernilton has anti-inflammatory and anti-edema effects, contributes to the regulation of metabolic processes.
One of the pharmacological properties of the drug is dose-dependent inhibition of COX and 5-lipoxygenase, which leads to inhibition of the synthesis of inflammatory mediators of the arachidonic acid cycle: prostaglandins and leukotrienes and, consequently, to reduce inflammation and swelling of prostate tissue. The drug helps to eliminate pain.
Cernilton has a muscle relaxant effect, which leads to relaxation of smooth muscle elements of the posterior wall of the urethra and improve urination.
The drug reduces the volume of the prostate gland by inhibiting 5-alpha reductase, selectively blocks alpha1 - adrenoreceptors of the smooth muscle elements of the urethra, has anti-androgenic effect. Improves erectile function.
Indications
In the complex therapy:
acute and chronic prostatitis, benign prostatic hyperplasia, benign prostatic hyperplasia in combination with prostatitis.
Composition
1 capsule contains: a water-soluble fraction of the microbiologically fermented pollen extract of plants Graminex G60 - 120.00 mg; fat soluble fraction of Graminex microbiologically fermented plant pollen extractÒGFX - 6.00 mg.
Cernilton® is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Cernilton | Graminexx | USA | capsules |
Cernilton | Graminexx | USA | pills |
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Dosage and Administration
The drug is administered orally 30 minutes before meals, washed down with a small amount of water.
Acute prostatitis: 2 capsules 3 times a day. The duration of the course of treatment is determined by the attending physician and is usually 3 months.
Chronic prostatitis: 1 capsule 3 times a day. The duration of treatment is determined individually by the attending physician and is usually from 3 to 6 months.
Benign prostatic hyperplasia: 1 capsule 3 times a day. Duration of treatment is determined individually by the attending physician and is usually from 6 to 12 weeks, but can be increased to 6 months.
Adverse reactions
Allergic reactions are possible; in rare cases, nausea may occur.
Contraindications
Hypersensitivity to the drug.
- P4.031 Effects of cerebrum compositum and ubichinoncompositum in patients with postradiation on brain damage
- Usefulness of Cernilton in the treatment of benign prostatic hyperplasia
- A Pollen Extract (Cernilton) in Patients with Inflammatory Chronic Prostatitis–Chronic Pelvic Pain Syndrome: A Multicentre, Randomised, Prospective, Double-Blind, Placebo-Controlled Phase 3 Study
- Treatment of Outflow Tract Obstruction due to Benign Prostatic Hyperplasia with the Pollen Extract Cernilton : A Double-blind, Placebo-controlled Study
- MP16-05 EVIPROSTAT HAS AN IDENTICAL EFFECT COMPARED TO POLLEN EXTRACT (CERNILTON) IN PATIENTS WITH CHRONIC PROSTATITIS/CHRONIC PELVIC PAIN SYNDROME: A RANDOMIZED, PROSPECTIVE STUDY
- Cochrane Database of Systematic Reviews (Reviews) || Cernilton for benign prostatic hyperplasia
- Gräserpollen (Cernilton®) bei chronischer nicht bakterieller Prostatitis - Randomisierte Studie mit 139 Patienten belegt die Wirksamkeit
- Eviprostat has an identical effect compared to pollen extract (Cernilton) in patients with chronic prostatitis/chronic pelvic pain syndrome: a randomized, prospective study
- Cochrane Database of Systematic Reviews (Reviews) || Cernilton for benign prostatic hyperplasia