Buy Nimbex ampoules 2 mg/ml, 2.5 ml, 5 pcs

Cisatracurium besylate

Brand GlaxoSmithKline

In stock 1513 Items

Available since: 2019-09-19

Dosage form

ampoules

Brand & Manufacturer

Package Size

2 mg/ml, 2.5 ml, 5 pcs

$86.56

Quantity

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Clinical Pharmacology

Muscle relaxant, non-depolarizing. Nimbex binds to the n-cholinergic receptors of motor nerve endings and acts as an acetylcholine antagonist, causing a competitive blockade of neuromuscular conduction, which can be quickly eliminated by anti-cholinesterase agents such as neostigmine and edrofoniya. The effect of Nimbex on patients with malignant hyperthermia in history has not been studied.

Indications

Myorelaxation during surgery, tracheal intubation, mechanical ventilation.

Composition

1 ml. contains cisatracuria besyat 2 mg.

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Dosage and Administration

Intravenous, bolus. In adults and in children from 1 month. up to 12 years for tracheal intubation - 0.15 mg / kg, quickly, within 5-10 s. 2-3 minutes after the injection, there is a neuromuscular block sufficient for tracheal intubation. With the introduction of higher doses, the block comes faster. Sequential administration of maintenance doses does not lead to a progressive increase in the duration of the effect. After the spontaneous recovery of the neuromuscular block has begun, its speed does not depend on the total dose administered.

Contraindications

Hypersensitivity to cisatracuria, atracuria, and benzenesulfonic acid, a child's age (up to 2 years). With caution: disruption of EC or electrolyte balance, burns, carcinomatosis, neuromuscular diseases (including myasthenia, myasthenic syndrome) or other conditions, which can lead to prolonged neuromuscular blockade, hemiparesis, paraparesis, pregnancy, lactation.

Drug interactions

The effect strengthens drugs for inhalation general anesthesia (halothane, ether), other non-depolarizing muscle relaxants; antibiotics (aminoglycosides, polymyxins, spectinomycin, tetracyclines, lincomycin and clindamycin); antiarrhythmic drugs (propranolol, BMCC, lidocaine, procainamide, quinidine); diuretics (furosemide, thiazides); salts MD2 +, salts Li +; ganglion-blocking drugs (trimetafan, hexametonium). The previous long-term use of phenytoin or carbamazepine - weakening the effect of the drug. Prior administration of suxamethonia does not affect the duration of the neuromuscular block. The introduction of suxamethonia in order to increase the duration of the neuromuscular block caused by non-depolarizing muscle relaxants can lead to a long and complex blockade, which can be difficult to eliminate with the help of anticholinesterase drugs. Incompatible with ketorolac, trometamol, propofol.

Special instructions

Dose adjustment is not required in elderly patients, in patients with impaired renal function, liver, or with CVD diseases. The drug causes paralysis of the respiratory and other skeletal muscles, but does not affect the mind or the pain threshold. It should be administered only by an anesthesiologist or a specialist with experience in the use of muscle relaxants, with the possibility of tracheal intubation, mechanical ventilation and adequate oxygenation of the blood. When diluted in Ringer's lactate solution, the injection drug is chemically unstable, stable only in acidic solutions, so it should not be mixed in one syringe or injected simultaneously through a single needle with alkaline solutions, for example sodium thiopental.

Overdosage

Symptoms: the expected symptoms are due to prolonged paralysis of the respiratory muscles and its consequences.

Treatment: It is very important to maintain the ventilation and oxygenation of the blood until the restoration of adequate spontaneous respiration. If signs of spontaneous neuromuscular conduction recover, it can be accelerated by administering anticholinesterase drugs.