Cocarnit®

Pharmacodynamics

The drug is a rationally selected complex of metabolic substances and vitamins. Triphosadenine is adenosine derivative, stimulates metabolic processes. It has a vasodilating effect, including on the coronary and cerebral arteries. Improves metabolism and energy supply of tissues. It has antihypertensive and antiarrhythmic effects. Under the influence of ATP, blood pressure decreases, smooth muscles relax, and nerve impulses improve. Cocarboxylase is a coenzyme formed in the body from thiamine (vitamin B1) supplied from the outside. Included in the carboxylase enzyme that catalyzes the carboxylation and decarboxylation of α-keto acids. Indirectly promotes the synthesis of nucleic acids, proteins and lipids. Reduces the concentration of lactic and pyruvic acids in the body, promotes the absorption of glucose. Improves the trophism of the nervous tissue. Cyanocobalamin (vitamin B12) in the body is converted to methylcobalamin and 5-deoxyadenosylcobalamin. Methylcobalamin is involved in the homocysteine ​​conversion reaction in methionine and S-adenosylmethionine, the key metabolic reactions of the pyrimidine and purine bases (and, therefore, DNA and RNA). With vitamin deficiency in this reaction, it can replace methyltetrahydrofolic acid, thus violating the folic acid metabolic reactions.

5-deoxyadenosylcobalamin serves as a cofactor in the isomerization of L-methylmalonyl-CoA to succinyl-CoA - an important metabolic reaction of carbohydrates and lipids. Vitamin B12 deficiency leads to impaired proliferation of rapidly dividing cells of the hematopoietic tissue and epithelium, as well as disruption of the formation of the myelin sheath of neurons. Nicotinamide is one of the forms of vitamin PP, is involved in redox processes in the cell, improves carbohydrate and nitrogen metabolism, regulates tissue respiration.

Pharmacokinetics

Triphosadenine After parenteral administration, it penetrates into the cells of the organs, where it splits into adenosine and inorganic phosphate, releasing energy. In the future, the decay products are included in the resynthesis of ATP. Cocarboxylase Rapidly absorbed after intramuscular administration. It penetrates into most tissues of the body. Metabolic decomposed. Metabolism is excreted primarily by the kidneys.

Cyanocobalamin

In the blood, cyanocobalamin binds to transcobalamins I and II, which transport it to tissues. Deposited mainly in the liver. Communication with plasma proteins 0 90%. Quickly and completely absorbed after intramuscular and subcutaneous administration. The maximum concentration after intra-muscular injection is reached after 1 hour. It is excreted from the liver by the bile into the intestine and again absorbed into the blood. The half-life is 500 days. Excreted in normal renal function - 7-10% by the kidneys, about 50% by the intestines. With reduced kidney function - 0-7% by the kidneys, 70-100% - by the intestines. Penetrates through the placental barrier into breast milk.4

Nicotinamide

Quickly distributed to all tissues. Penetrates through the placental barrier and into breast milk. Metabolized in the liver to form nicotinamide-N-methylnicotinamide. Excreted by the kidneys. The half-life of plasma is about 1.3 h, the stationary volume of distribution is about 60 liters, the total clearance is about 0.6 l / min.