Clinical Pharmacology
The combined drug for the treatment of cough, has a mucolytic and expectorant effect, and also has anti-inflammatory activity. The action of Codelac® Broncho is due to the pharmacological properties of its components: Ambroxol has a secretomotor, secretolytic and expectorant effect, normalizes the disturbed ratio of the serous and mucous components of sputum, increases the secretion of surfactant in the alveoli. Reduces the viscosity of phlegm and promotes its discharge. On average, when taken orally, the effect of Ambroxol occurs after 30 minutes, the duration of action is 6-12 hours, depending on the dose taken. Glycyrrate (glycyrrhizic acid and its salts) has anti-inflammatory and antiviral effects. It has a cytoprotective effect due to antioxidant and membrane stabilizing activity. It potentiates the action of endogenous glucocorticosteroids, providing anti-inflammatory and anti-allergic effects. Due to its pronounced anti-inflammatory activity, it helps to reduce the inflammatory process in the respiratory tract. Thermopsis extract has an expectorant effect, exerting a moderate irritating effect on the receptors of the gastric mucosa, and reflexively increases the secretion of the bronchial glands. Sodium bicarbonate shifts the medium (pH) of bronchial mucus to the alkaline side, reduces the viscosity of sputum, stimulates the motor function of the ciliated epithelium and bronchioles.