

A drug that improves brain metabolism. Cortexin is a lyophilisate obtained by acetic extraction from the cerebral cortex of cattle or pigs, containing low molecular weight active neuropeptides, the molecular weight of which does not exceed 10,000 daltons, sufficient for penetration through the BBB.
Cortexin has a tissue-specific multifunctional effect on the brain, which is manifested in metabolic regulation, neuroprotection, functional neuromodulation, and neurotrophic activity.
Cortexin increases the efficiency of the energy metabolism of brain cells, improves intracellular protein synthesis.
Cortexin regulates lipid peroxidation processes in brain cells, reduces the formation of free radicals, blocks the processes of free radical oxidation. The drug eliminates the imbalance of inhibitory and excitatory amino acids, has a moderate GABA-ergic action.
The drug has a positive effect in violation of cognitive functions, improves concentration, short-term memory, ability to learn, accelerates the restoration of brain function after stress effects, regulates the level of serotonin and dopamine. Stimulates the process of mental activity, without exerting an excessive activating effect, restores the bioelectric activity of the brain.
Cortexin stimulates reparative processes in the brain.
- violations of cerebral circulation;
- encephalopathies of various origins;
- acute and chronic encephalitis and encephalomyelitis;
- vegetative dystonia;
- epilepsy;
- traumatic brain injury;
- viral and bacterial neuroinfections;
- cerebral palsy;
- delayed psychomotor and speech development in children;
- asthenia;
- impaired memory, thinking, reduced ability to learn.
1 bottle of lyophilisate contains:
active substance: Cortexin (complex of water-soluble polypeptide fractions) 5 mg,
excipient: glycine (stabilizer)
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The drug is administered intramuscularly.
The contents of the vial are dissolved before injection in 1–2 ml of a 0.5% solution of procaine (novocaine), water for injection or 0.9% solution of sodium chloride, directing the needle to the wall of the vial to avoid foaming, and injected once daily: adults at a dose of 10 mg for 10 days; children with body weight up to 20 kg at a dose of 0.5 mg / kg, with a body weight of more than 20 kg - at a dose of 10 mg for 10 days.
If necessary, repeat the course after 3-6 months. In hemispheric ischemic stroke in acute and early recovery periods, adults at a dose of 10 mg 2 times a day (morning and afternoon) for 10 days, with a repeated course after 10 days.
No adverse events reported.
Is possible individual hypersensitivity to the drug.
Individual intolerance to the drug.
Drug interaction of the drug is not described.
Before use, it is recommended to consult with a specialist.
Studies and clinical trials of Cortexin (Click to expand)