Corvalol
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2019-09-19
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Clinical Pharmacology
Corvalol is a sedative of plant origin, a combination drug.
Phenobarbital has sedatavny and mild hypnotic effects. It helps to reduce the excitation of the central nervous system and facilitates the onset of natural sleep.
Ethylbromovaleanate also has a sedative and antispasmodic effect.
Peppermint Oil has a reflex vasodilator and antispasmodic activity.
Indications
Corvalol is prescribed as a sedative and vasodilator for functional disorders of the cardiovascular system, for neurosis-like conditions accompanied by increased irritability, impaired sleep, tachycardia, a state of agitation with pronounced vegetative manifestations, and as a spasmolytic agent for intestinal spasms.
Composition
1 ml of solution contains
Ethyl α-bromoisovaleric acid ester 20 mg
Phenobarbital 18.26 mg
Sodium hydroxide 3.15mg
Peppermint oil 1.42 mg
Rectified ethyl alcohol of the highest purification 0.58 ml
Purified water 0.42 ml
Corvalol is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Corvalol | Moscow Pharmaceutical Factory | Russia | drops |
| Corvalol | Pharma Start | Russia | pills |
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Dosage and Administration
The dosage is set individually. Adults are usually prescribed 15-30 drops 3 times daily before meals. With tachycardia, a single dose may increase to 40-50 drops. Children are prescribed up to 3-15 drops per day, depending on the age and clinical picture of the disease.
The duration of the drug is determined by the physician individually.
Adverse reactions
Corvalol is generally well tolerated. In some cases, drowsiness and slight dizziness may occur during the daytime.
With prolonged use of large doses may develop chronic bromine poisoning, manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.
If any adverse (unusual) effects that are not reflected in the instructions appear, they should be reported to your doctor.
Contraindications
Hypersensitivity to the drug; severe impaired renal and / or liver function.
Drug interactions
Drugs that inhibit the central nervous system, increase the effect. Phenobarbital (an inducer of microsomal oxidation) can reduce the effectiveness of drugs metabolized in the liver (including coumarin derivatives, griseofulvin, GCS, oral contraceptives); enhances the effect of local anesthetic, analgesic and hypnotic drugs.
Pregnancy and Lactation
Prescription of the drug during pregnancy is possible only under strict indications. If necessary, the appointment of the drug during the feeding period should decide the issue of termination of breastfeeding.
Special instructions
The drug contains 58% by volume of ethanol and phenobarbital, therefore, patients receiving Corvalol are not recommended to engage in activities related to increased attention and requiring quickness of mental and motor responses.
With prolonged use of the drug may form of drug dependence; possible accumulation of bromine in the body and the development of poisoning them.
Overdosage
Symptoms: CNS depression, nystagmus, ataxia, decreased blood pressure, agitation, chronic bromine intoxication (depression, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements). Treatment: symptomatic, with CNS depression, caffeine, Nikethamide.
- Brand name: Corvalol
- Active ingredient: Phenobarbital, Alpha Bromovaleric Acid Ethyl Ester, Sodium Hydroxide, Peppermint Oil
- Dosage form: Drops for oral administration
- Manufacturer: Moscow Pharmaceutical Factory
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