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Combined drug, the action of which is due to the properties of its constituent substances. It has a sedative and antispasmodic effect, moderate cardiotonic action (slows down the rhythm and increases the strength of heart contractions), has moderate hypotensive properties.
Ethylbromizovalerianat has a sedative and antispasmodic effect caused by irritation, mainly of oral and nasopharyngeal receptors, a decrease in reflex excitability in the central nervous system, and an increase in inhibition in the neurons of the cortex and subcortical structures of the brain, as well as a decrease in the activity of the central vasomotor centers and direct local spasmolytic structures and direct local spasmolytic brain structures, and direct local spasmolytic structures and direct local spasmolytic brain vasculature smooth muscle. By the nature of the action is close to the preparations of Valerian.
Motherwort herb has a pronounced sedative effect (sedative), moderately reduces the frequency and increases the strength of heart contractions, shows moderate hypotensive properties.
Peppermint oil has a reflex vasodilating, antispasmodic, mild choleretic, antiseptic effect. The mechanism of action is associated with the ability to irritate the “cold” receptors of the mucous membrane of the oral cavity and reflexively expand the vessels of the heart and brain. Eliminates the phenomenon of flatulence due to irritation of the receptors of the mucous membrane of the gastrointestinal tract (GIT), increasing intestinal motility.
Diphenhydramine is a blocker H1- histamine receptors of the first generation. Action on the central system due to blockade H1- histamine receptors of the brain m-cholinergic receptors. Reduces or prevents histamine-induced smooth muscle spasms, increased capillary permeability, tissue swelling, itching and hyperemia, has antiemetic, sedative effects, and has a hypnotic effect. Antagonism with histamine is manifested to a greater extent in relation to local vascular reactions than to systemic, that is, lower blood pressure.
Increased nervous irritability; as a sedative for sleep disorders that are not associated with organic disorders of the central nervous system; neurasthenia.
On 1 ml:
Active ingredients: motherwort herbs tincture (motherwort tincture) - 720.00 mg, ethyl bromovaleriate (ethyl ester alpha-bromizovaleric acid) - 20.00 mg, peppermint leaf oil (peppermint oil) - 1.42 mg, diphenhydramine hydrochloride - 1 , 00 mg.
Excipients: purified water - up to 1 ml.
Note. To obtain 1000 ml of motherwort tincture use 200 g of motherwort herb and a sufficient amount of ethyl alcohol 70%.
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Dosage and Administration
Valocordin is taken orally, before meals, with a small amount of liquid. The dose is set individually.
Adults usually appoint 15-20 drops 3 times a day. In case of disturbed sleep, the dose can be increased to 30 drops. The duration of the drug is set individually by a doctor.
Valocordinum is generally well tolerated even with prolonged use.
In some cases: drowsiness and slight dizziness may occur during the daytime.
With long-term use of large doses: possible development of chronic bromine poisoning, manifestations of which are: depressive mood, apathy, rhinitis, conjunctivitis, hemorrhagic diathesis, impaired coordination of movements.
Seldom: hypersensitivity may cause skin reactions.
If any side effects (unusual) that are not reflected in the instructions, must be reported to your doctor.
Carefully: liver diseases, alcoholism, traumatic brain injury, brain diseases The product contains ethanol.
With the simultaneous use of Valocordin with sedatives - enhancing the effect. Simultaneous use with neuroleptics and tranquilizers strengthens, and with stimulants of the central nervous system - weakens the effect of each of the components of the drug. Alcohol enhances Valocordin effects and may increase its toxicity. The presence of phenocarbital in Valocordin can induce liver microsomal enzymes, and this makes it undesirable to use it simultaneously with drugs that are metabolized in the liver, since their concentration and, consequently, their effectiveness will change as a result of more rapid metabolism (indirect anticoagulants, antibiotics, sulfonamides, etc. .).
Phenobarbital weakens the effect of coumarin derivatives, glucocorticosteroids, griseofulvin, oral contraceptives.
Pregnancy and Lactation
If necessary, the appointment of the drug during lactation should decide on the termination of breastfeeding.
The drug contains 55% by volume of ethanol (the absolute content of ethanol in the maximum single dose (30 drops) is 0.469 grams) and phenobarbital, therefore Valocordin, even if properly used, can weaken the patients' ability to react quickly in certain situations, such as when staying outdoors or when servicing cars. This is particularly pronounced when taking alcohol at the same time.
With prolonged use of the drug may form of drug dependence; possible accumulation of bromine in the body and the development of poisoning them.
Symptoms: with mild and moderate intoxication, drowsiness, dizziness, psychomotor disturbances are observed. In severe cases, coma, lower blood pressure, respiratory failure, tachycardia, vascular collapse, reduced peripheral reflexes.
Treatment: wash the stomach, take activated charcoal and immediately call a doctor.
- Brand name: Corvalol
- Active ingredient: Peppermint leaves oil, Motherwort herb extract, Ethylbromizovalerianate, Diphenhydramine
- Manufacturer: Moscow Pharmaceutical Factory