Creatine Phosphate
Alpha wasserman
1754 Items
2019-09-19
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Clinical Pharmacology
Neotone - a drug that improves the metabolism of the myocardium and muscle tissue. The chemical structure is similar to macroergic endogenous phosphocreatine. Slows down the process of destruction of the sarcolemma of ischemic cardiomyocytes and myocytes, provides intracellular transport of energy. By improving microcirculation, the drug reduces the size of the area of necrosis and ischemia. With ischemia and post-ischemic reperfusion, it causes an antiarrhythmic effect, which is associated with a decrease in the ectopic activity of the ventricles and preservation of the physiological function of cells of Purkinje fibers.
Indications
- acute myocardial infarction;
- chronic heart failure;
- intraoperative myocardial ischemia;
- intraoperative limb ischemia;
- acute violation of cerebral circulation;
- in sports medicine: to prevent the development of the syndrome of physical overvoltage and improve adaptation to extreme physical exertion.
Composition
1 bottle contains phosphocreatine 1 g.
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Dosage and Administration
Withacute myocardial infarction On the 1st day, 2-4 g intravenously are administered, followed by drip infusion of 8-16 g in 200 ml of 5% glucose solution for 2 hours. times / day On the 3rd day, 2 g / d drip is prescribed 2 times / day.
If necessary, a course of drug infusion of 2 g 2 times / day can be performed for 6 days.
Withchronic heart failure administered in / in the drip 1-2 g 2 times / day for 10-14 days.
Withintraoperative myocardial ischemia the drug is administered as part of a conventional cardioplegic solution in the amount of 3 g per 1 liter. Neotone is added to the solution immediately prior to administration. It is recommended to conduct a course of infusion of the drug 2 g 2 times / day for 3-5 days prior to surgery, and within 1-2 days after surgery.
With the possibility of developmentintraoperative limb ischemia It is recommended to introduce 2-4 g of the drug intravenously before the operation with subsequent infusion of 8-10 g in a 5% glucose solution during the operation and the reperfusion period.
Adverse reactions
Decrease in blood pressure (with a rapid on / in the introduction).
Contraindications
Hypersensitivity to the drug.
Drug interactions
When used as part of a combination therapy, Neoton contributes to the effectiveness of antiarrhythmic, antianginal drugs, as well as drugs that have a positive effect on the myocardial inotropic function.
Pregnancy and Lactation
Data on the safety and efficacy of the drug Neoton during periods of pregnancy and lactation (breastfeeding) are not provided.
Special instructions
The drug should be administered as soon as possible after the onset of signs of ischemia, which provides a more favorable prognosis of the disease.
Neotone is not used for emergency correction of disorders of the heart.
- Brand name: Neoton
- Active ingredient: Phosphocreatine
- Dosage form: Lyophilized powder for preparing a solution for infusion.
- Manufacturer: Alpha wasserman
- Country of Origin: Italy
Studies and clinical trials of Creatine Phosphate (Click to expand)
- Action of Aqueous Extracts of Bearberry and Cowberry Leaves and Wild Camomile and Pineapple-weed Flowers on Escherichia coli Surface Structures
- Simultaneous determination of myocardial creatine phosphate and adenine nucleotides by reversed-phase HPLC
- Histochemical studies of alkaline phosphatases in the tissues of the rat using frozen sections. II. Substrate specificity of enzymes hydrolyzing adenosine-triphosphate, muscle- and yeast-adenylic acids, and creatine-phosphate at high pH; the histochemical demonstration of myosin ATP-ase
- Diffusion coefficients of atp and creatine phosphate in isolated muscle: pulsed gradient 31p nmr of small biological samples
- Extraction and Assay of Creatine Phosphate, Purine, and Pyridine Nucleotides in Cardiac Tissue by Reversed-Phase High-Performance Liquid Chromatography
- Enzymic determination of inorganic phosphate in the presence of creatine phosphate
- Three-step preparation and purification of phosphorus-33-labeled creatine phosphate of high specific activity
- Chemically coupled spectrophotometric assays based on flow injection analysis: Determination of nitrogenase by assays for creatine, ammonia, hydrazine, phosphate, and dithionite
- Determiantion of creatine phosphate levels in brain tissue by isocratic reverse-phase, ion-paired high-performance liquid chromatography
- The creatine phosphate energy shuttle—The molecular asymmetry of a “pool”
- Computerized calculation of in vitro generation of ATP and creatine phosphate induced by respiration in human muscle mitochondria
- High-performance liquid chromatographic method for the simultaneous determination of myocardial creatine phosphate and adenosine nucleotides
- Isocratic high-performance liquid chromatographic analysis of myocardial creatine phosphate and adenine nucleotides
- Simultaneous determination of myocardial nucleotides, nucleosides, purine bases and creatine phosphate by ion-pair high-performance liquid chromatography
- Potassium contractures and creatine phosphate breakdown in frog muscle
- An improvement in the method for separation of certain nucleosides nucleotide and creatine phosphate.
- Novel dual-wavelength monitoring approach for the improved rapid separation and estimation of adenine nucleotides and creatine phosphate bu high-performance liquid chromatography
- A sensitive and rapid method for separating adenine nucleotides and creatine phosphate by ion-pair reversed-phase high-performance liquid chromatography
- Simultaneous quantification of myocardial adenine nucleotides and creatine phosphate by ion-pair reversed-phase high-performance liquid chromatography
- Interactions between vanadyl(IV) cation and the system creatine, creatine phosphate and creatinine
- Muscle creatine phosphate in gyrate atrophy of the choroid and retina with hyperornithinaemia–clues to pathogenesis
- Preincubation with Creatine Enhances Levels of Creatine Phosphate and Prevents Anoxic Damage in Rat Hippocampal Slices
- ATP, creatine phosphate, and mechanical activity in rainbow trout myocardium under inhibition of glycolysis and cell respiration
- The effects of phosphate administration on phosphoryl-creatine, glycogen, and lactate levels in animal muscle
- Effect of adaptation to repeated stress on cardiac function repair and creatine phosphate level restoration following total ischemia (31P-NMR investigation)
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