Cyanamide
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2019-09-19
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The action of cyanamide is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol. This leads to an increase in the concentration of the ethyl alcohol metabolite - acetaldehyde, which causes negative sensations (flushing, nausea, tachycardia, shortness of breath, etc.), which make alcohol consumption extremely unpleasant after taking the drug. This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages. The sensitizing effect of cyanamide on alcohol appears earlier (after about 45-60 minutes) and lasts shorter (about 12 hours) than the effect of disulfiram. It is used to treat patients with chronic alcoholism and prevent relapse.
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Treatment is prescribed after a thorough examination of the patient and warning of the consequences and complications.
The drug is administered orally in 12-25 drops (36-75 mg of cyanamide) 2 times a day with an interval of 12 hours according to an individual scheme.While taking the drug with alcohol, the following symptoms appear: severe hyperemia of the skin, "pulsation" in the head and neck, nausea, tachycardia, difficulty breathing, weakness, blurred vision, profuse sweating, chest pain. In the most severe cases - vomiting, lowering blood pressure, respiratory depression, collapsed state.
The nature and severity of symptoms depend on the amount of alcohol and drug taken. In severe cases, it is necessary to carry out symptomatic therapy aimed at maintaining the functions of the respiratory and cardiovascular systems, intravenous infusion of antihistamines.
MIDZO should only be used under medical supervision and with the knowledge of the patient. You may have a reaction to alcohol contained in some drugs and foods.
Treatment with MIDZO can only be started 12 hours after the last alcohol intake. Cyanamide should be used with caution in cases where a reaction to simultaneous intake with alcohol may entail a risk to the patient's health: with hyperthyroidism, diabetes mellitus, epilepsy, cardiovascular diseases, kidney disease.
With long-term use, it is recommended to monitor the function of the thyroid gland at least once every six months.
Studies and clinical trials of Cyanamide (Click to expand)
- Fast-atom Bombardment (FAB) Mass Spectra of Nitrile or Cyanamide Complexes with the {M(Ph2PCH2CH2PPh2)2}n+ (M=Fe or Re) Metal Sites. Application to Reactions Induced under FAB Conditions
- Crystal Structure Refinement of Lead Cyanamide and the Stiffness of the Cyanamide Anion
- High Pressure Behavior of Mercury Cyanamide HgCN2
- Nitridometallat-Cyanamide von Molybdän und Wolfram
- Cyanamide Synthesis by the Palladium-Catalyzed Cleavage of a Si−N Bond
- Cyanamide Synthesis by the Palladium-Catalyzed Cleavage of a Si−N Bond
- [Inorganic Syntheses] Inorganic Syntheses Volume 3 || Cyanamide
- Copper-Catalyzed Domino Synthesis of Benzimidazo[2,1-b]quin- azolin-12(6H)-ones Using Cyanamide as a Building Block
- Silatautomere Organylcarbodiimide/-cyanamide
- The Reaction between Halosilanes and Silver Cyanamide
- New Amino Acid Derivatives from Cyanamide and Cyanacetamide
- Improved Preparation of Monosodium Cyanamide
- Biochemical Degradation of Cyanamide and Dicyandiamide
- The First Structure of a Lithiated Cyanamide; Synthesis of (PhNCNLi · HMPA)n by Extrusion of N2 and S from 5-Phenylamino-1,2,3,4-thiatriazole with Li Reagents and HMPA
- Structural characterization of residual lignins isolated with cyanamide-activated hydrogen peroxide from various organosolvs pretreated wheat straw
- Cycloacylierung monosubstituierter Cyanamide mit Oxalylchlorid
- Bioavailability of cyanamide in fasted and unfasted rats
- Inhibition of rat hepatic mitochondrial aldehyde dehydrogenase isozymes by repeated cyanamide administration: Pharmacokinetic-pharmacodynamic relationships
- Ueber substituirte Cyanamide und Thiocarbamide
- Pseudohalogenverbindungen, XVII. CF3S-substituierte Cyanamide, Chlorformamidine und deren chemisches Verhalten
- Pseudoelement Compounds, X Synthesis and Crystal Structure of New Complexes of the Type trans-[Pt(H)X(PPh3)2 with Cyanamide and Cyanomethanide Ligands
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