

Levamisole - antihelminthic drug. Acting on ganglion-like nematode formations, Decaris causes depolarizing neuromuscular paralysis of the membrane of helminth muscles, blocks succinate dehydrogenase, inhibits fumarate dehydrogenase, disrupting the course of the bioenergetic processes of helminths. Thus, paralyzed nematodes are removed from the body by the normal intestinal motility within 24 hours after taking the drug.
Pharmacokinetics
Levamisole, when taken orally at a dose of 50 mg, is rapidly absorbed from the gastrointestinal tract. The maximum plasma concentration is determined on average 1.5–2 hours after taking the drug. Levamisole is extensively metabolized in the liver, its main metabolites are p-hydroxy-levamisole and its glucuronide.
T1 / 2 from the body is 3-6 hours. In an unchanged form, the kidneys excrete less than 5%, through the intestines less than 0.2% of the injected dose.
Infection with helminths of Ascaris lumbrocoides, Necator and Americanus Ancylostoma duodenale.
1 tablet contains:
Active substance: levamisole hydrochloride - 177 mg, which corresponds to the content of levamisole - 150 mg;
Excipients: corn starch, lactose monohydrate, sucrose, talc, povidone, magnesium stearate.
No customer reviews for the moment.
The drug should be taken after meals with a small amount of water in the evening. There is no need to take laxatives or a special diet. If necessary, the drug can be repeated after 7-14 days.
Headache, insomnia, dizziness, palpitations, convulsions, dyspeptic symptoms (nausea, vomiting, abdominal pain, diarrhea).
There are reports of the development of side effects from the central nervous system (encephalopathy) 2-5 weeks after taking the drug, as well as allergic reactions (skin rash), seizures.
In most patients, these phenomena were reversible, and early use of glucocorticosteroid therapy improved the prognosis.
The connection of these symptoms with taking Decaris is not quite convincing. With the use of large doses or with long-term therapy, leukopenia, agranulocytosis, tremor can be observed.
Carefully: patients with renal and / or liver failure, with inhibition of bone marrow hematopoiesis.
At the same time taking the drug with alcohol disulfiram-like phenomena are observed.
Care is required when applying Decaris with drugs that affect blood formation.
While taking the drug with coumarin-like anticoagulants, the prothrombin time may increase, so you need to adjust the dose of oral anticoagulant. Decaris increases the level of phenytoin in the blood, the poet, while applying them simultaneously, must control the level of phenytoin in the blood.
Decaris cannot be used simultaneously with lipophilic drugs, such as carbon tetrachloride, tetrachlorethylene, henopodium oil, chloroform or ether, since its toxicity may increase.
Prescription drug during pregnancy is possible only in the case when the intended benefit to the mother outweighs the potential risk to the fetus.
If necessary, the use of the drug during breastfeeding should decide on the termination of breastfeeding.
Alcohol should not be consumed during and after taking the drug for 24 hours. There is insufficient evidence that levamisole, used as an anthelmintic agent, inhibits the nervous system.
The effect of the drug on the ability to drive and other mechanisms
Due to the fact that while taking the drug may occur transient, mild dizziness, caution should be exercised when driving a car or when working with mechanisms during the entire course of treatment.
Symptoms: When a large dose of levamisole (over 600 mg) was administered, the following signs of intoxication were described: nausea, vomiting, drowsiness, convulsions, diarrhea, headache, dizziness and confusion.
Treatment: in case of accidental overdose, and if it did not take long after taking the drug, gastric lavage is performed. Monitoring of vital body functions and symptomatic therapy is necessary. If there is evidence of anticholinesterase action, atropine may be administered.
Studies and clinical trials of Levamisole (Click to expand)