Delagil® [Chloroquine]

Brand Meda Pharma GmbH & Co. KG

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Clinical Pharmacology

The antiprotozoal agent also has an immunosuppressive and anti-inflammatory effect. Delagil causes the death of asexual erythrocyte forms of all types of plasmodia. It has a gametocidal effect, with the exception of Plasmodium falciparum (exhibits anti-gametocidal action).

Indications

Malaria (prevention and treatment of all types), extraintestinal amebiasis, amebic liver abscess, systemic lupus erythematosus (SLE) (chronic and subacute forms), rheumatoid arthritis, scleroderma, photodermatosis.

Composition

1 tablet contains chloroquine 250 mg

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Dosage and Administration

Delagil is taken orally, after meals.
In the treatment of malaria prescribed 2-2.75 g per course of treatment: 1 g / first day, after 11-12 hours 0.5 g, on the second and third day - 0.5-0.75 g at one time. The maximum dosage for adults is 1.5 g at a time. Children 6-10 years prescribed 0.25 g in the first day, then 0.125 g in the second and third days of treatment. Children 10-15 years old - 0.5 g / first day, then 0.25 g each on the second and third day.
Prevention of malaria infection: 0.5 g twice a week, then 0.5 g once a week. In the case of rheumatoid arthritis, Delagil is taken at a rate of 0.5 g / day for 2 doses for 6–8 days. Then daily 0.25 g for 12 months.

Adverse reactions

- Of the nervous system: dizziness, psychomotor agitation, headache, insomnia, psychosis, neuropathy, seizures.
- From the side of the musculoskeletal system: myopathy.
- On the part of sensitive analyzers: hearing loss, tinnitus, impaired visual perception, corneal clouding, retinopathy, accommodation disturbance, reversible keratopathy.
- On the part of the digestive system: nausea, vomiting, diarrhea, anorexia, abdominal pain of a spastic nature, weight loss, hepatotoxicity.
- From the side of vascular system: development of arterial hypotension, cardiomyopathy is possible.
- Skin manifestations: dermatitis, pruritus, rash, photosensitivity, impaired skin pigmentation, hair loss.

Contraindications

Renal and hepatic failure, severe cardiac arrhythmias, oppression of blood formation in the bone marrow, porphyrinuria, neutropenia, hypersensitivity to the constituent components of the drug, children under 6 years of age.

Drug interactions

The combined use of other antimalarial drugs enhances the action of Delagil. Can not be taken in conjunction with gold medications, cytostatics, penicillamine, levamisole, because This may increase the side effects of the drug. When used together with MAO inhibitors, the toxic effect is enhanced. With long-term use of Delagil together with cardiac glycosides may develop glycoside intoxication. Ethanol enhances the toxic effect of Delagil on the liver.

Overdosage

Overdose of this drug causes loss of consciousness, vomiting, respiratory depression, seizures, collapse. In case of overdose, it is necessary to flush the stomach, take the adsorbents inside. In severe cases of poisoning, plasmapheresis and peritoneal dialysis are possible.