Dexa-gentamicin
Ursapharm Artsnaymittel
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Clinical Pharmacology
The combined drug for local use in ophthalmology.
The drug provides a sufficient dose and compatibility of both active components, and also reduces the likelihood of error in the selection of the dose in the case of separate use of the components included in the preparation.
Gentamicin is a water soluble antibiotic of the aminoglycoside group. It has a bactericidal effect against a wide range of gram-positive and gram-negative bacteria. Gentamicin does not penetrate the intact cornea. Corneal damage and inflammation leads to the penetration of gentamicin through the cornea into the anterior chamber of the eye 15 minutes after instillation of eye drops or laying eye ointment.
Dexamethasone is a synthetic GCS, the anti-inflammatory and antiallergic action of which is 25 times greater than the action of cortisol, which is a natural endogenous GCS. Dexamethasone may penetrate through the cornea with the intact epithelium into the moisture of the anterior chamber of the eye; however, in the case of an inflammatory process or damage to the epithelium, the rate of penetration of dexamethasone through the cornea increases significantly.
Pharmacokinetics
When applied topically, systemic absorption is low.
Indications
- infections of the anterior segment of the eye caused by gentamicin-sensitive microflora (conjunctivitis, keratitis, blepharitis, barley);
- allergic processes of the anterior segment of the eye, accompanied by bacterial infection;
- prevention and treatment of inflammation in the postoperative period (removal of cataracts, antiglaucomatous operations).
Composition
1 ml of eye drops contains:
Active ingredients
- Dexamethasone Sodium Phosphate 1 mg.
- Gentamicin Sulfate 5 mg,
- Including Gentamicin 3 mg.
Excipients
Benzalkonium chloride, potassium hydrogen phosphate, potassium dihydrogen phosphate, sodium chloride, water d / i.
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Dosage and Administration
Dexa-gentamicin eye drops are instilled into the conjunctival sac 1-2 drops 4-6 times a day.
The duration of treatment with Dexa-gentamicin eye drops usually does not exceed 2-3 weeks.
Adverse reactions
In rare cases, an allergic reaction and a burning sensation after the use of the drug. Prolonged use of the drug can cause secondary glaucoma and steroid cataracts, so when using the drug for more than 2 weeks, as well as in patients with a history of glaucoma, it is recommended to regularly monitor intraocular pressure.
Contraindications
- keratitis caused by herpes zoster (tree keratitis), chicken pox and other viral diseases of the cornea and conjunctiva;
- microbacterial infections of the eye;
- fungal diseases of the eye;
- acute purulent eye diseases with damage to the corneal epithelium;
- corneal epitheliopathy;
- increased intraocular pressure;
- hypersensitivity to any of the components of this drug.
It is not recommended to use contact lenses during treatment with Dexa-gentamicin eye drops.
Pregnancy and Lactation
To date, clinical trials data regarding the use of Dexa-gentamicin eye drops during pregnancy, lactation, as well as in children are absent. However, the drug can be used if the intended benefit to the mother outweighs the possible risk to the fetus.
Special instructions
If the use of contact lenses is necessary, they should be removed before using the drug Dexa-gentamicin and installed again no earlier than 20 minutes later.
The patient should be informed that in the event of side effects, stop treatment immediately and consult an ophthalmologist.
Use in Pediatrics
To date, data from clinical studies of the safety and efficacy of the use of the drug Dexa-gentamicin in children are not available. The use of the drug in pediatrics is possible if the expected therapeutic effect outweighs the potential risk of side effects.
Influence on ability to drive motor transport and control mechanisms
Immediately after the use of the drug Dexa-gentamicin, a short-term impairment of visual acuity may occur, leading to a slowdown in psychomotor reactions. Therefore, it is not recommended to use the drug immediately before working with the mechanisms and driving vehicles.
- Brand name: Detralex
- Active ingredient: Hesperidin, Diosmin
- Dosage form: Suspension for oral administration homogeneous, light yellow color, with a characteristic odor.
- Manufacturer: Salut-M
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