Buy Dexalgin granules 25 mg sachets 10 pcs
  • Buy Dexalgin granules 25 mg sachets 10 pcs


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Clinical Pharmacology

pharmachologic effect

NSAIDs. It has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is based on the inhibition of the synthesis of prostaglandins due to the suppression of COX.

Analgesic effect occurs 30 minutes after administration, the duration of action - 4-6 hours.


After taking the drug inside Cmax dexketoprofen in humans is achieved on average after 30 minutes (15-60 minutes). Plasma protein binding - 99%. Average Vd - less than 0.25 l / kg. T1 / 2 is 1.65 hours. It is metabolized. Excreted mainly by the kidneys as metabolites.


Mild and moderate intensity pain syndrome in the following diseases and conditions: acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondylitis, arthrosis, osteochondrosis); dysmenorrhea; toothache.


1 pack

Dexketoprofen trometamol 36.9 mg, which corresponds to the content of dexketoprofen 25 mg.

Excipients: ammonium glycyrrhizinate - 2 mg, neohesperidin dihydrochalkon - 1.5 mg, quinoline yellow dye (E104) - 1.2 mg, lemon flavoring - 40 mg, sucrose with colloidal silicon dioxide (500: 1) - 2418 mg.

Dexketoprofen is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Dexalgin Berlin-Chemie/Menarini Germany granules
Flamadex Sotex Russia pills
Ketodexal K.O.Romparm Company S.R.L Romania solution
Dexalgin Berlin-Chemie/Menarini Germany ampoules
Flamadex Sotex Russia solution
Dexalgin Berlin-Chemie/Menarini Germany pills

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Dosage and Administration

For oral use. The average recommended single dose is 12.5 mg - 1-6 times / day every 4-6 hours as needed, or 25 mg 1-3 times / day every 8 hours.

The maximum daily dose is 75 mg. Duration of use - no more than 3-5 days.

For patients with impaired liver or kidney function, the elderly, the initial dose is not more than 50 mg / day.

Adverse reactions

On the part of the digestive system: heartburn, abdominal pain; rarely - erosive and ulcerative lesions of the gastrointestinal tract.

From the nervous system: headaches, dizziness, nervousness, sleep disturbance, paresthesia.

Since the cardiovascular system: heartbeat, increased blood pressure.

Allergic reactions: skin rash, bronchospasm.

Others: chills, swelling of limbs, photosensitization; rarely - a change in the pattern of peripheral blood, renal dysfunction.


Peptic ulcer and duodenal ulcer, gastrointestinal bleeding, active bleeding of various origins, increased bleeding, anticoagulant therapy, Crohn's disease, ulcerative colitis, asthma (including history), severe heart failure, renal failure, hepatic insufficiency, pregnancy, lactation, hypersensitivity to dexketoprofen or other NSAIDs.

Drug interactions

With the simultaneous use of dexketoprofen with other NSAIDs may increase the risk of side effects.

With simultaneous use with lithium preparations may increase the concentration of the latter in the blood plasma.

Use dexketoprofen with caution in less than 24 hours before the start of application or after the end of therapy with methotrexate, since the plasma concentration of the latter (and, consequently, toxicity) may increase.

Selected cases of bleeding with the simultaneous use of NSAIDs and anticoagulants.

Special instructions

Care should be taken when prescribing the drug to elderly patients, patients with allergic reactions, systemic connective tissue diseases and patients with impaired blood formation.

Patients should be informed that in the event of side effects, as well as in the absence of clinical effect, it is necessary to inform the attending physician within 3-5 days of treatment.

Special care is required with simultaneous use of dexketoprofen with phenytoin, sulfonamides, and drugs that reduce blood clotting.

Influence on ability to drive motor transport and control mechanisms

Since dexketoprofen can cause a decrease in the ability to concentrate, it should be used with caution in patients engaged in potentially hazardous activities that require increased attention and quickness of psychomotor reactions.

  • Brand name: Dexalgin
  • Active ingredient: Dexketoprofen
  • Dosage form: Granules for the preparation of oral solution
  • Manufacturer: Berlin-Chemie / Menarini

Studies and clinical trials of Dexketoprofen (Click to expand)

  1. Stereoselective inhibition of rat brain cyclooxygenase by dexketoprofen
  2. Photocontact dermatitis due to dexketoprofen
  3. Photocontact dermatitis due to dexketoprofen
  4. Comparative study of analgesic efficacy and morphine-sparing effect of intramuscular dexketoprofen trometamol with ketoprofen or placebo after major orthopaedic surgery
  5. Systematic review of dexketoprofen in acute and chronic pain
  6. Comparison of intravenous dexketoprofen and dipyrone in acute renal colic
  7. Photoallergic contact dermatitis from dexketoprofen: study of 6 cases
  8. Neutropenia, thrombocytopenia and hepatic injury associated with dexketoprofen trometamol therapy in a previously healthy 35-year-old woman
  9. Effects of tramadol and dexketoprofen on analgesia and gastrointestinal transit in mice
  10. Photocontact dermatitis because of oral dexketoprofen
  11. Subeffective doses of dexketoprofen trometamol enhance the potency and duration of fentanyl antinociception
  12. Development of an LC–DAD Method for Analysis of Dexketoprofen, Tramadol, and Haloperidol. Study of the Stability of Mixtures Used for Patient-Controlled Analgesia
  13. Low doses of nitroparacetamol or dexketoprofen trometamol enhance fentanyl antinociceptive activity
  14. Subanalgesic doses of dexketoprofen and HCT-2037 (nitrodexketoprofen) enhance fentanyl antinociception in monoarthritic rats
  15. Interaction between dexibuprofen and dexketoprofen in the orofacial formalin test in mice
  16. The NSAID dexketoprofen trometamol is as potent as μ-opioids in the depression of wind-up and spinal cord nociceptive reflexes in normal rats
  17. Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice
  18. Dexketoprofen trometamol in post-operative pain management
  19. Dexketoprofen-induced antinociception in animal models of acute pain: Synergy with morphine and paracetamol
  20. Dexketoprofen-induced antinociception in animal models of acute pain: Synergy with morphine and paracetamol
  21. Double-blind evaluation of short-term analgesic efficacy of orally administered dexketoprofen trometamol and ketorolac in bone cancer pain
  22. Oral dexketoprofen for pain treatment during diagnostic hysteroscopy in postmenopausal women

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