Diacerein

Brand Micro Labs Ltd

In stock 1542 Items

Available since: 2019-09-19

All payments are SSL encrypted
Full Refund if you haven't received your order
International shipping to the USA, UK and Europe

Clinical Pharmacology

Artroker is a nonsteroidal anti-inflammatory agent (NSAID). After ingestion, diacerein is rapidly absorbed from the gastrointestinal tract and is fully deacetylated to Rein. Simultaneous use of the drug with food increases bioavailability by 25%. Cmax of rhein in plasma is reached after 1.44 minutes. T1 / 2 of plasma is 255 minutes. The connection of rhein with albumin is almost 100%. With a single dose of 50 mg Cmax reaches 3.15 mg / l. With repeated use of the drug Cmax increases due to cumulation of the drug. Reina is excreted by the kidneys in unchanged form (20%) and as glucuronide (60%) and sulfate (20%). Rein penetrates the placental barrier and BBB.

Indications

Primary and secondary osteoarthritis.

Composition

1 capsule contains:
Active substance: Diacerein 50.0 mg
Excipients: lactose monohydrate, povidone, croscarmellose sodium, sodium lauryl sulfate, magnesium stearate, colloidal silicon dioxide
Hard gelatin capsule (body): gelatin, water, brilliant blue dye, titanium dioxide, phloxin B dye, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl sulfate
Hard gelatin capsule (cap): gelatin, water, brilliant blue dye, titanium dioxide, quinoline yellow dye, phloxin B dye, methyl parahydroxybenzoate, propyl parahydroxybenzoate, sodium lauryl sulfate

Diacerein is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Artroker	Micro Labs Ltd	India	capsules
Diaflex rompharm	K.O.Romparm Company S.R.L	Romania	capsules
Artrodarin	TRB Pharma	Argentina	capsules

No customer reviews for the moment.

Write your review

Dosage and Administration

Standard intake of 1 capsule 2 times a day (in the morning and in the evening, after meals). Capsules should be swallowed whole, not liquid, and drink water. The effect of the treatment should be expected in 2-4 weeks. Art broker is applied continuously for a long time or courses of at least 4 months. The duration of the break between treatments is set by the doctor.

Adverse reactions

With increased sensitivity to the components of the drug may experience allergic reactions of varying degrees, rash, itching. In the initial period of administration of the drug, phenomena from the alimentary system can take place temporarily: diarrhea, nausea, vomiting, and abdominal pain. In this case, the dose should be reduced to 1 capsule per day.
There may be an intense urine staining from yellow to brown (depending on pH), which does not require a dose reduction (withdrawal) of the drug.

Contraindications

Individual intolerance to the components of the drug Artroker or high sensitivity to anthraquinone drugs (for example, laxatives). Children's age (up to 18 years). Pregnancy, lactation. Severe hepatic or renal failure, intestinal obstruction, inflammatory bowel disease. Lactose intolerance, lactase deficiency, glucose galactose malabsorption.

Drug interactions

The art broker is not recommended to be taken together with drugs that affect the consistency of the intestinal contents (for example, a large amount of fiber).
Antacids reduce the absorption of the drug. When taken concomitantly with antibiotics or chemotherapeutic drugs that affect the intestinal microflora, the frequency of intestinal adverse events may increase.

Special instructions

The duration of treatment, depending on the result achieved, can be long. In the period preceding the development of the therapeutic effect, Artroker can be taken simultaneously with non-narcotic analgesics and other nonsteroidal anti-inflammatory drugs. Periodic monitoring of blood parameters, liver enzymes, urine activity is necessary. When kidney function deteriorates, the doctor must decide to reduce the dose of the drug or cancel it.

Overdosage

With an overdose possible diarrhea, weakness. In case of overdose or accidental use of drugs by children, it is necessary to consult a doctor. Symptomatic treatment.