Diazolin® [Mebhydrolin]

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Available since: 2019-09-19

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Clinical Pharmacology

Diazolin - histamine H blocker₁-receptors.
It has anti-allergic, antipruritic, anti-exudative, as well as a weak sedative effect. Blocks histamine H1 receptors, lowers the tone of smooth muscles (bronchi, gastrointestinal tract, uterus), reduces capillary permeability and the development of edema, prevents the occurrence of itching.

Indications

Prevention and treatment of the following conditions:
Allergic rhinitis (seasonal, chronic), pollinosis.
Allergic conjunctivitis.
Drug allergies.
Hives.
Quincke swelling.
Itchy dermatosis (eczema, neurodermatitis).
Skin reaction to insect bites.

Composition

1 tablet contains mebhydrolin 50 mg.

Mebhydrolin is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
Diazolin	Ozon	Russia	dragee
Diazolin	Ozon	Russia	pills

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Dosage and Administration

Diazolin is for oral use after eating.
For adults and children over 10 years old: 50-300 mg per day. The maximum single dose - 300 mg daily - 600 mg.
Children 5-10 years old: 100-200 mg per day.
Children 2-5 years: 50-150 mg per day.

Adverse reactions

From the nervous system and sense organs:

Fatigue, dizziness, paresthesia, tremor; when using high doses - slowing down the reaction rate, drowsiness, anxiety (at night), blurred vision.

From the organs of the gastrointestinal tract:

Rarely - dry mouth, nausea, heartburn, irritation of the gastric mucosa, pain in the epigastric region, vomiting, constipation.

From the urinary system:

Impaired urination

From the side of blood-forming organs:

Rarely - granulocytopenia, agranulocytosis.

Other:

Dry mouth, urinary retention, allergic reactions.

In children - paradoxical reactions

Irritability, irritability, sleep disturbance, tremor.

Contraindications

Prostatic hypertrophy, angle-closure glaucoma, gastric ulcer and duodenal ulcer, inflammatory diseases of the gastrointestinal tract in the acute phase; Hypersensitivity to Mebhydrolin, children under 2 years old.
Restrictions on the use of:
Pyloric stenosis, epilepsy, cardiac arrhythmia.

Drug interactions

Diazolin enhances the effect of CNS depressants.

Pregnancy and Lactation

Contraindicated use during pregnancy and breastfeeding.

Special instructions

Be wary appointed during pregnancy and lactation.
Caution is also needed when using against the background of liver and kidney diseases (dose adjustment and intervals between doses are possible).
With caution, the drug is prescribed to patients engaged in potentially hazardous activities that require increased attention and quick psychomotor reactions.