Dicetel® [Pinaverium bromide]
Abbott
539 Items
2019-09-19
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Clinical Pharmacology
Dicetel - myotropic antispasmodic drug with a moderately pronounced m-anticholinergic action.
Dicetel reduces spasm of smooth muscles of internal organs, reduces the secretion of hydrochloric acid.
Accelerates the evacuation function of the stomach, has no pronounced anticholinergic action.
Indications
- spasms of smooth muscles of the abdominal organs: dyskinesia of the colon, biliary dyskinesia;
- preparation for X-ray examination of the digestive tract with the use of barium.
Composition
Active ingredient: Pinavery bromide 50 mg;
Excipients: colloidal silicon dioxide; microcrystalline cellulose; talc; magnesium stearate; pregelatinized starch; lactose monohydrate
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Dosage and Administration
Dicetel adults are prescribed 1 tablet 2 times a day (morning and evening).
If necessary (in exceptional cases), the dose may be increased to 3 tablets per day.
Adverse reactions
From the digestive system: rarely - dyspepsia, constipation, nausea.
Other: rarely - allergic reactions.
Contraindications
- hypersensitivity
- paralytic ileus,
- intestinal atony,
- toxic megacolon,
- severe ulcerative colitis.
Pregnancy and Lactation
During pregnancy and lactation (breastfeeding) Ditsetel prescribed only in cases where the intended benefits to the mother outweigh the potential risk to the fetus or child.
Special instructions
Ditsetel prescribed to children only in cases where the intended benefit outweighs the potential risk.
Overdosage
Symptoms: overdose can lead to gastrointestinal disorders such as flatulence and diarrhea.
Treatment: special antidote unknown; symptomatic treatment is recommended.
- Brand name: Dicetel®
- Active ingredient: Pinaverium bromide
- Dosage form: pills, coated.
- Manufacturer: Abbott
- Country of Origin: USA
- A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of pinaverium bromide in human plasma: application to a pharmacokinetic study in healthy volunteers
- Pinaverium bromide: A calcium channel blocker acting selectively on the gastrointestinal tract
- Involvement of a CCK-dependent capsaicin-sensitive afferent pathway in the inhibitory effect of pinaverium bromide on the colonic motor response to eating in rats
- Effect of pinaverium bromide on electrical and mechanical activity of smooth muscle cells
- Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide
- Effects of an Intestinal Smooth Muscle Calcium Channel Blocker (Pinaverium Bromide) on Colonie Transit Time in Humans
- INHIBITION OF THE COLONIC MOTOR RESPONSE TO EATING BY PINAVERIUM BROMIDE IN IRRITABLE BOWEL SYNDROME PATIENTS
- Comparison of pinaverium bromide, manganese chloride and D600 effects on electrical and mechanical activities in rat uterine smooth muscle
- Action of pinaverium bromide on calmodulin-regulated functions
- Effects of oral pinaverium bromide on colonic response to food in irritable bowel syndrome patients
- Effects of pinaverium bromide and verapamil on the motility of the rat isolated colon
- Action of the calcium channel blocker, pinaverium bromide, on the cholecystokinin-mediated colonic motor response to a meal in rats: J. Fioramonti, M.O. Christen∗, I. Dupré, L. Buéno. Department of Pharmacology, INRA, Toulouse and ∗Solvay Pharma/LTM, Suresnes, France
- Pinaverium bromide inhibition of substance P-induced descending activation in the guinea-pig distal colon
- Action of a calcium channel blocker, pinaverium bromide, on the CCK-mediated colonic motor response to a meal in rats
- Pinaverium bromide a GI selective calcium antagonist diminishes FOS expression in rats following nociceptive stimulus
- Effect of pinaverium bromide on jejunal motility and colonic transit time in healthy humans
- Modification of colonic response to eating (CRE) induced by pinaverium bromide (PB) in control and IBS patients
- Su2028 Pinaverium Bromide Plus Symeticone Interacts With the IL-8 +396 GG Variant in the Improvement of Abdominal Pain in IBS. A Report From the Mexican IBS Study Group
- Tu1404 Improvement of Abdominal Pain and Bloating is Independently Influenced by Male-Gender and a Combination Therapy With Pinaverium Bromide+Simethicone. a Report From the Mexican IBS Working Group
- T1264 The Effect of 4 Weeks of Treatment with Pinaverium Bromide (PB) + Symethicone (S) On Symptom Intensity in IBS-ROME III Patients. a Report of the Mexican IBS Working Group
- Influence of pinaverium bromide on the dynamics of pain intensity and ‘deviation’ of pancreatic enzymes to blood in patients with chronic pancreatitis (CP)
- Pinaverium bromide prevents spinal Fos expression in acetic acid-induced visceral pain in rats
- Action of pinaverium bromide, a calcium-antagonist, on gastrointestinal motility disorders
- S1332 Expected Frequency of Stool Patterns According to the Bristol Scale After 4 Weeks of Treatment With Pinaverium Bromide + Simethicone for IBS ROME III Patients. A Report From the Mexican IBS Working Group
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