Dimephosphone
Tatkhimpharmpreparaty
1257 Items
2019-09-19
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Clinical Pharmacology
DIEMPHOSPHAN improves the regulation of cerebral circulation, normalizes the reactions of cerebral vessels and blood supply to the brain, improves venous outflow.
In violation of cerebral circulation relieves vasomotor cephalgia; reduces heart and respiratory failure central origin.
Normalizes the acid-base state in acidosis of various etiologies. It exhibits membrane stabilizing, anti-inflammatory, immunomodulatory, antihypoxant, antimutagenic and radioprotective actions, inhibits platelet aggregation.
When applied topically, it has an antiseptic effect, increases the protective function of the skin and mucous membranes.
Indications
Cerebral circulatory disorders, neurosurgical surgery of the brain and spinal cord, head injury, Meniere's syndrome and disease, autonomic dysfunction, acute and chronic diseases of the respiratory organs with subcompensated pulmonary hypertension, bronchospastic variant of bronchial obstruction (chronic bronchitis, bronchitis, bronchitis, bronchial obstruction, chronic bronchitis, bronchitis, bronchial obstruction, chronic bronchitis, chronic bronchitis , acidosis of various etiologies. Atopic bronchial asthma and pollinosis in children, infectious-inflammatory and allergic diseases of the skin and mucous membranes.
Composition
Active ingredients: dimethyloxobutylphosphonyl dimethyl 15 g
Excipients: purified water to 100 ml.
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Dosage and Administration
The inside is prescribed in the form of a solution for adults and children at 30-50 mg / kg per reception. When violations of cerebral circulation and Meniere's syndrome is prescribed 1-4 times within 1-4 weeks.
For planned neurosurgical operations, they are prescribed for 5 days before and 10-14 days after surgery. With traumatic brain injury, the duration of treatment from 3 weeks to 2 months.
With autonomic dysfunction, respiratory diseases and acidosis, the duration of treatment is 3-4 weeks. For atopic bronchial asthma, children are prescribed for 2-4 weeks.
For the prevention of exacerbation of hay fever, take for 3 weeks before the expected seasonal deterioration and throughout the flowering of the plant-allergen.
Externally used in infectious-inflammatory-allergic diseases of the skin and mucous membranes of the solution in the form of dressings, turun and lotions daily until recovery.
For the prevention of radiation mucositis, gauze napkins moistened with a solution are placed in the projection of radiation beams 20 minutes before the exposure of the dose.
Adverse reactions
- nausea,
- vomiting
- heartburn,
- diarrhea (by ingestion),
- sleepiness (at the beginning of treatment)
Contraindications
- hypersensitivity
- chronic renal failure 2-3 degrees,
- epileptic seizures.
Special instructions
When drowsiness occurs, refrain from driving vehicles and activities that require increased attention and speed of reaction.
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- Synthesis and Therapeutic Use of Dimephosphone
- Effects of Dimephosphone on Mineral Metabolism of High Dose Prednisolone Treated Rats Compared to Etidronic Acid
- Dimephosphone analogs: a pharmacological aspect
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