Buy Dimephosphone vials 15%, 100 ml
  • Buy Dimephosphone vials 15%, 100 ml


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Clinical Pharmacology

DIEMPHOSPHAN improves the regulation of cerebral circulation, normalizes the reactions of cerebral vessels and blood supply to the brain, improves venous outflow.

In violation of cerebral circulation relieves vasomotor cephalgia; reduces heart and respiratory failure central origin.

Normalizes the acid-base state in acidosis of various etiologies. It exhibits membrane stabilizing, anti-inflammatory, immunomodulatory, antihypoxant, antimutagenic and radioprotective actions, inhibits platelet aggregation.

When applied topically, it has an antiseptic effect, increases the protective function of the skin and mucous membranes.


Cerebral circulatory disorders, neurosurgical surgery of the brain and spinal cord, head injury, Meniere's syndrome and disease, autonomic dysfunction, acute and chronic diseases of the respiratory organs with subcompensated pulmonary hypertension, bronchospastic variant of bronchial obstruction (chronic bronchitis, bronchitis, bronchitis, bronchial obstruction, chronic bronchitis, bronchitis, bronchial obstruction, chronic bronchitis, chronic bronchitis , acidosis of various etiologies. Atopic bronchial asthma and pollinosis in children, infectious-inflammatory and allergic diseases of the skin and mucous membranes.


Active ingredients: dimethyloxobutylphosphonyl dimethyl 15 g

Excipients: purified water to 100 ml.

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Dosage and Administration

The inside is prescribed in the form of a solution for adults and children at 30-50 mg / kg per reception. When violations of cerebral circulation and Meniere's syndrome is prescribed 1-4 times within 1-4 weeks.

For planned neurosurgical operations, they are prescribed for 5 days before and 10-14 days after surgery. With traumatic brain injury, the duration of treatment from 3 weeks to 2 months.

With autonomic dysfunction, respiratory diseases and acidosis, the duration of treatment is 3-4 weeks. For atopic bronchial asthma, children are prescribed for 2-4 weeks.

For the prevention of exacerbation of hay fever, take for 3 weeks before the expected seasonal deterioration and throughout the flowering of the plant-allergen.

Externally used in infectious-inflammatory-allergic diseases of the skin and mucous membranes of the solution in the form of dressings, turun and lotions daily until recovery.

For the prevention of radiation mucositis, gauze napkins moistened with a solution are placed in the projection of radiation beams 20 minutes before the exposure of the dose.

Adverse reactions

  • nausea,
  • vomiting
  • heartburn,
  • diarrhea (by ingestion),
  • sleepiness (at the beginning of treatment)


  • hypersensitivity
  • chronic renal failure 2-3 degrees,
  • epileptic seizures.

Special instructions

When drowsiness occurs, refrain from driving vehicles and activities that require increased attention and speed of reaction.

Studies and clinical trials of Dimephosphone (Click to expand)
  1. Effects of dimephosphone, xydiphone, and ionol on the content and activities of rat liver cytochromes P-450 during long-term treatment with phenobarbital
  2. Effects of dimephosphone, xydiphone, and ionol on the content and activities of rat liver cytochromes P-450 during long-term treatment with phenobarbital
  3. Mechanisms of the Effect of Dimephosphone on Synaptic Transmission in the Frog Neuromuscular Junction
  4. Therapeutic Efficiency of Dimephosphone and Xydiphone in Experimental Pulse Therapy with Prednisolone
  5. Effect of Dimephosphone (Monophosphonate) on the Course of Pregnancy and Fetal Development in Rats
  6. Investigation of conformational state of molecules of dimephosphone H3C-(C=O)CH2-C(CH3)2-(P=O)(OCH3)2by means of vibrational (IR, Raman) spectroscopy and molecular mechanics
  7. IR Spectral study of the drug, dimephosphone, in aqueous media
  8. Dimephosphone effect on vessel wall antiaggregating potential
  9. Dimephosphone analogs: I. Synthesis and structure of some dimephosphone aryl- and acylhydrazones
  10. Development of the pharmaceutical composition micephosphone containing dimephosphone and its study by modeling osteoporosis
  11. Dimephosphone analogues. 3. Molecular and crystal structure of dimephosphone pyridinoylhydrazones exhibiting antiphthisic activity
  12. Synthesis and Structure of Dimephosphone Pyridinoylhydrazones with Antimycobacterial Activity
  13. Dimephosphone analogs: II. Dialkyl(diaryl)-(2-methyl-4-oxopent-2-yl)phosphine oxide oximes: Synthesis, structure, and generation of iminoxyl radicals
  14. Synthesis and Therapeutic Use of Dimephosphone
  15. Effects of Dimephosphone on Mineral Metabolism of High Dose Prednisolone Treated Rats Compared to Etidronic Acid
  16. Dimephosphone analogs: a pharmacological aspect

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