Dioctahedral Smectite
Pharmacor Production
1291 Items
2019-09-19
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Clinical Pharmacology
The drug is of natural origin, has an adsorbing effect. It stabilizes the mucous barrier, forms polyvalent bonds with mucus glycoproteins, increases the amount of mucus, improves its gastroprotective properties (in relation to the negative effect of hydrochloric acid, bile salts, microorganisms and their toxins). It has selective sorption properties, which are explained by its discoid-crystalline structure. It adsorbs bacteria and viruses located in the lumen of the gastrointestinal tract. In therapeutic doses, it has no direct effect on intestinal motility.
Dioctahedral Smectite is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Diosmectite | Pharmacor Production | Russia | powder |
| Neosmectin | Pharmstandard | Russia | tea bags |
| Smecta | Ipsen pharma | France | powder |
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Dosage and Administration
Inside
Acute diarrhea
Children, including babies: up to 1 year - 2 sachets per day for 3 days, then - 1 sachet per day; over 1 year old - 4 sachets per day for 3 days, then 2 sachets per day.
Adults: The recommended dosing regimen is 6 sachets per day.
Other indications
Children, including babies: up to 1 year - 1 sachet per day; 1-2 years - 1-2 sachets per day; older than 2 years - 2-3 bags per day.
Adults: 3 sachets per day.
A course of treatment for 3–7 days is recommended.
With esophagitis drug Smecta® should be taken after meals, with other indications - between meals.
For children, the contents of the bags are dissolved in a baby bottle (50 ml) and distributed into several doses throughout the day or mixed with any semi-liquid product (cereal, mashed potatoes, compote, baby food). For adults, the contents of the bags are dissolved in 1/2 glass of water, gradually pouring the powder and stirring it evenly. The prescribed dose is divided into 3 doses throughout the day.
Adverse reactions
In clinical studies, rare cases of constipation have been reported. In all cases, this phenomenon was mild and disappeared after an individual change in the dosing regimen. In routine practice in very rare cases, hypersensitivity reactions have been reported, incl. urticaria, rash, itching or angioedema.
Carefully: severe chronic constipation in history.
Drug interactions
The drug can reduce the rate and degree of absorption of simultaneously taken drugs. It is not recommended to take the drug Smecta® simultaneously with other drugs.
Pregnancy and Lactation
Smecta is approved for use in pregnant and lactating women. Dosage and dosage adjustment is not required.
Special instructions
It is recommended to observe the interval of 1-2 hours between taking the drug Smecta® and other drugs.
With caution used in patients with severe chronic constipation in history.
In children with acute diarrhea, the drug should be used in conjunction with measures for rehydration. If necessary, adults can also be prescribed drug therapy in conjunction with measures for rehydration.
The complex of measures for rehydration is assigned depending on the course of the disease, the age and characteristics of the patient.
Influence on ability to drive and work with mechanisms. No information available.
Overdosage
Overdose can cause severe constipation.
- Brand name: Diosmectite
- Active ingredient: Dioctahedral Smectite
- Manufacturer: Pharmacor Production
- Country of Origin: Russia
Studies and clinical trials of Dioctahedral Smectite (Click to expand)
- Efficacy of dioctahedral smectite in treating patients of diarrhea-predominant irritable bowel syndrome
- Investigation of dioctahedral smectite hydration properties by modeling of X-ray diffraction profiles: Influence of layer charge and charge location
- Effect of exchangeable cation on the swelling property of 2:1 dioctahedral smectite—A periodic first principle study
- Effect of an “in situ” hydrous strain on the ionic exchange process of dioctahedral smectite: Case of solution containing (Cu2+, Co2+) cations
- Dioctahedral smectite reactions at elevated temperatures: Effects of K-availability, Na/K ratio and ionic strength
- Comparative efficacy of dioctahedral smectite (Smecta®) and a probiotic preparation in chronic functional diarrhoea
- Effects of Temperature, pH, and Iron/Clay and Liquid/Clay Ratios on Experimental Conversion of Dioctahedral Smectite to Berthierine, Chlorite, Vermiculite, or Saponite
- Heterogeneous reactions of dioctahedral smectites in illite-smectite and kaolinite-smectite mixed-layers: applications to clay materials for engineered barriers
- A Novel Method to Correlate Layer Charge and the Catalytic Activity of 2:1 Dioctahedral Smectite Clays in Terms of Binding the Interlayer Cation Surrounded by Monohydrate
- Best Dioctahedral Smectite for Nitrogen Heterocyclics AdsorptionA Reactivity Index Study
- Intermolecular reactivity study to scale adsorption property of para- and meta-substituted nitrobenzene over 2:1 dioctahedral smectite
- Technique for determination of the content of smectite layers in the dispersed dioctahedral K-bearing micaceous minerals
- [Studies in Surface Science and Catalysis] Nanoporous Materials IV, Proceedings of the 4th International Symposium on Nanoporous Materials Volume 156 || Effect of exchangeable cation and hydration layer on the swelling property of 2:1 dioctahedral smectite clay—a periodic density functional study
- Efficacy of Dioctahedral Smectite in Acute Watery Diarrhea in Indian Children: A Randomized Clinical Trial
- A comparison of dioctahedral smectite and iodine glycerin cream with topical mouth rinse in treatment of chemotherapy induced oral mucositis: A pilot study
- A chemical and thermodynamic model of aluminous dioctahedral 2:1 layer clay minerals in diagenetic processes; regular solution representation of interlayer dehydration in smectite
- Quantum mechanical calculations of dioctahedral 2:1 phyllosilicates: Effect of octahedral cation distributions in pyrophyllite, illite, and smectite
- Measuring the Layer Charge of Dioctahedral Smectite by O–D Vibrational Spectroscopy
- A chemical and thermodynamic model of dioctahedral 2:1 layer clay minerals in diagenetic processes; dehydration of dioctahedral aluminous smectite as a function of temperature and depth in sedimentary basins
- Management of Lithuanian children's acute diarrhoea with Gastrolit solution and dioctahedral smectite
- Influence of pH, layer charge location and crystal thickness distribution on U(VI) sorption onto heterogeneous dioctahedral smectite
- Catalytic Properties of a Heated Ammonium-Saturated Dioctahedral Smectite
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