Diosmin

In stock 1797 Items

Available since: 2019-09-19

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Clinical Pharmacology

Diosmin belongs to the group of bioflavonoids, has phlebotonizing (reduces vein distensibility, improves vein tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases tone and frequency of lymphatic capillary contraction, increases their functional density, reduces lymphatic pressure), improves microcirculation (increases the resistance of capillaries (dose-dependent effect), reduces their permeability), reduces the adhesion of leukocytes to the venous wall and their migration into paravenous tissues, improve AET oxygen diffusion and perfusion in the skin tissue, possesses anti-inflammatory action. Strengthens the vasoconstrictor action of adrenaline, norepinephrine, blocks the production of free radicals, the synthesis of prostaglandins and thromboxane.

Indications

- Varicose veins of the lower extremities (elimination of symptoms);

- Chronic lymphatic insufficiency of the lower extremities (elimination of symptoms);

- Acute hemorrhoids (in combination therapy to relieve symptoms); - Violations of microcirculation (for example, in idiopathic edema).

Composition

One tablet, film coated, contains:
active ingredient: diosmin - 600.00 mg;
excipients: microcrystalline cellulose - 241.50 mg; talc - 18.00 mg; Hyprolosis (hydroxypropylcellulose) - 13.50 mg; croscarmellose sodium - 13.50 mg; magnesium stearate - 9.00 mg; silicon dioxide colloid hydrophobic - 4.50 mg;
film coating: [hypromellose - 16.20 mg, talc - 5.40 mg, titanium dioxide - 2.79 mg, macrogol 4000 (polyethylene glycol 4000) - 2.43 mg, iron dye red oxide (iron oxide) - 0.18 mg] or [dry mixture for film coating, containing hypromellose (60%), talc (20%), titanium dioxide (10.33%), macrogol 4000 (polyethylene glycol 4000) (9%), dye of iron oxide red (iron oxide ) (0.67%)] - 27.00 mg.

Diosmin is marketed under different brands and generic names, and comes in different dosage forms:

Brand name	Manufacturer	Country	Dosage form
			pills
Flebaven			pills
Phlebodia 600	Innotera Laboratories	France	pills
Phlebofe	Ozon	Russia	pills
Venolek	Canonpharma	Russia	pills

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Dosage and Administration

The drug is intended for oral administration. With varicose veins of the lower extremities and chronic lymphatic insufficiency The drug is used 1 tablet per day in the morning on an empty stomach. The duration of therapy is usually 2 months. In severe forms of chronic lymphatic insufficiency (edema, pain, convulsions, etc.), treatment may be longer (the total duration of continuous therapy should not exceed three to four months). Dosmin treatment courses are repeated after 2-3 months. For the treatment of chronic lymphovenous insufficiency during the II and III trimester of pregnancy, the drug is used 1 tablet 1 time per day. The duration of treatment is not more than 30 days. You must stop taking the drug 2-3 weeks before delivery. In case of exacerbation of hemorrhoids, the Drug is used 2-3 pills per day with meals for 7 days. Then, if necessary, you can continue taking the drug on 1 tablet 1 time per day for 1-2 months. In case of violations of microcirculation. The drug is used 1 tablet per day in the morning on an empty stomach. The duration of therapy is usually 1-2 months. If you miss one or more doses of the drug, you must continue to use the drug in the usual mode and in the usual dose.

Adverse reactions

Classification of the incidence of side effects according to the recommendations of the World Health Organization (WHO):
very often ≥ 1/10;
often from ≥ 1/100 to <1/10;
infrequently from ≥ 1/1000 to <1/100;
rarely from ≥ 1/10000 to <1/1000;
very rarely <1/10000, including individual messages;
frequency is unknown - according to the available data it is not possible to establish the frequency of occurrence.
From the gastrointestinal tract:
often - nausea, vomiting, diarrhea, dyspeptic disorders, heartburn, constipation;
infrequently - colitis.
From the side of the central nervous system:
rarely - headache, malaise, dizziness.
Skin and subcutaneous adipose tissue:
rarely - skin rash, itching.
Allergic reactions:
rarely - urticaria;
frequency unknown - isolated swelling of the face, lips, eyelids; in exceptional cases, angioedema (angioedema).
If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects that are not indicated in the instruction, inform your doctor.

Contraindications

- Hypersensitivity to the drug;

- Children's age up to 18 years (experience of application is limited);

- Pregnancy (I term) and the period of breastfeeding (experience with limited use).

Drug interactions

Clinically significant effects of the interaction of diosmin with other drugs are not described.

Special instructions

Treatment of acute hemorrhoids is carried out in combination with other drugs. In the absence of a rapid clinical effect, it is necessary to conduct an additional examination and adjust the therapy being conducted.
In case of violation of the venous blood circulation (varicose veins of the lower extremities, chronic lymphatic venous insufficiency of the lower extremities), the maximum effect of treatment is provided by a combination of therapy with lifestyle changes: it is desirable to avoid a long stay in an upright position, to reduce overweight. In some cases, the improvement of blood circulation contributes to the wearing of special stockings (compression knitwear).
In the absence of a decrease or in case of worsening of the symptoms of the disease, consult a doctor.
Do not exceed the maximum time and recommended doses of the drug without consulting a doctor.

Overdosage

Symptoms
Symptoms of overdose are not described. Given the wide therapeutic range of Diosmin, the risk of intoxication during overdose seems to be insignificant.
Treatment
The specific antidote is unknown.