Diphenhydramine
Nizhpharm
1280 Items
2019-09-19
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Clinical Pharmacology
Antiallergic action of Psilo-Balsam® is associated with the presence of diphenhydramine hydrochloride in its composition, which is a blocker of H1-histamine receptors and as a result, it quickly reduces itching, reduces pain, hyperemia, reduces the increased capillary permeability, tissue edema; causes local anesthesia, due to which Psilo-Balsam® has a pleasant cooling effect. Special gel base protects the skin and leaves no visible trace.
Indications
Sunburn and I degree burns; insect bites; hives; pruritus of various origin (with the exception of itching with cholestasis): pruritic dermatosis, eczema, chicken pox, allergic skin irritations, contact dermatitis caused by contact with plants.
Composition
1 g of gel contains: active ingredient: diphenhydramine hydrochloride - 10.0 mg; excipients: cetylpyridinium chloride - 1.0 mg, macrogol glyceryl caprylocaprate - 150.0 mg, polyacrylic acid - 12.0 mg, trometamol - 22.2 mg, water - up to 1 g.
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Dosage and Administration
Topically. For adults and children over 2 years old, Psilo-Balsam® is applied to the affected skin (strip of gel 3-5 cm long on the palm-sized lesion area) 3-4 times a day and distributed by light massaging movements.
Adverse reactions
Rarely - skin hypersensitivity reactions (eczema, contact dermatitis). When external use of the drug side effects of a systemic nature is not marked.
Contraindications
Hypersensitivity to the drug; simultaneous use of any preparations containing diphenhydramine; use on extensive skin surfaces; children's age up to 2 years. Carefully Damage to the skin at the site of application, application to mucous membranes.
Drug interactions
Cases of interaction or incompatibility with other drugs when using external forms of diphenhydramine are not described.
Pregnancy and Lactation
It should be used with caution during pregnancy.
During treatment, breastfeeding is recommended to suspend.
Special instructions
Immediately after the application of Psilo-Balsam® (within 1-2 hours), prolonged exposure to the sun should be avoided to avoid the risk of photodermatosis. During treatment with Psilo Balm, alcohol should be avoided.
Overdosage
Symptoms: redness, moderate swelling of the skin on which the drug was applied.
Treatment: wash with water the area of the skin on which the preparation was applied.
- Brand name: Psilo balm
- Active ingredient: Diphenhydramine
- Dosage form: Gel for external use 1%. On 20 g or 50 g in aluminum tubes. Each tube, along with instructions for medical use of the drug is placed in a stack of cardboard.
- Manufacturer: Nizhpharm
- Country of Origin: Russia
Studies and clinical trials of Diphenhydramine (Click to expand)
- Simultaneous determination of diphenhydramine, itsN-oxide metabolite and their deuterium-labeled analogues in ovine plasma and urine using liquid chromatography/electrospray tandem mass spectrometry
- The antiemetic efficacy of secobarbital and chlorpromazine compared to metoclopramide, diphenhydramine, and dexamethasone: A randomized trial
- Antiemetic control and prevention of side effects of anti-cancer therapy with lorazepam or diphenhydramine when used in combination with metoclopramide plus dexamethasone. A double-blind, randomized trial
- Pharmacokinetics and renal excretion of diphenhydramine and its metabolites, diphenylmethoxyacetic acid and diphenhydramine-N-oxide, in developing lambs
- Acetaminophen and diphenhydramine as premedication for platelet transfusions: A prospective randomized double-blind placebo-controlled trial
- Synthesis and Pharmacology of Combined Histamine H1-/H2-Receptor Antagonists Containing Diphenhydramine and Cyproheptadine Derivatives
- Absence of pharmacokinetic interaction between orally co-administered naproxen sodium and diphenhydramine hydrochloride
- The disposition of diphenhydramine and four of its analogues in rabbits and implication for structure-activity relationship studies in drug design
- Diphenhydramine kinetics following intravenous, oral, and sublingual dimenhydrinate administration
- Simultaneous analysis of diphenhydramine and a stable isotope analog (2H10)diphenhydramine using capillary gas chromatography with mass selective detection in biological fluids from chronically instrumented pregnant ewest
- ChemInform Abstract: Synthesis of Azolylethyl Benzhydryl Ethers, Analogues of Diphenhydramine.
- Investigation of the sedative and congnitive effects of cyclobenzaprine compared with diphenhydramine and placebo using a computerized test battery
- Diphenhydramine-selective plastic membrane sensor and its pharmaceutical applications
- Identification of diphenhydramine metabolites in human urine by capillary electrophoresis-ion trap-mass spectrometry
- Effects of the antihistamine diphenhydramine on selected aquatic organisms
- Synthesis of tritium labelled diphenhydramine hydrochloride (benadryl )
- Diphenhydramine active uptake at the blood–brain barrier and its interaction with oxycodone in vitro and in vivo
- Comparative in vitro evaluation of cryogenine, cyproheptadine, and diphenhydramine as antagonists of furtrethonium, histamine, and serotonin
- Spectrophotometric determination of diphenhydramine hydrocholoride in an antiallergic cream
- Morphine-induced fetal malformations II: Influence of histamine and diphenhydramine
- Determination of diphenhydramine hydrochloride in elixir
- Analysis of acetaminophen, phenylephrine hydrochloride, diphenhydramine hydrochloride, and ascorbic acid in a capsule preparation
- Spectrophotometric determination of diphenhydramine hydrochloride using dipicrylamine
- Effect of diphenhydramine on methaqualone metabolism: An In vitro study
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