

The action of the drug is based on the blockade of acetaldehyde dehydrogenase, which is involved in the metabolism of ethyl alcohol.
This leads to an increase in the metabolite concentration of ethyl alcohol - acetaldehyde, which causes negative sensations (flushing, nausea, vomiting, tachycardia, lowering blood pressure (BP), etc.), which make alcohol use unpleasant after taking Teturam.
This leads to a conditioned reflex aversion to the taste and smell of alcoholic beverages.
Treatment and prevention of recurrence of chronic alcoholism.
As a detoxification agent for chronic nickel poisoning.
1 tablet contains teturam 150 mg
Disulfiram is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
Teturam | Pharmstandard | Russia | pills |
Esperal | Sanofi-aventis | France | pills |
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Treatment is prescribed after a thorough examination of the patient and warning about the consequences and complications.
The drug is taken orally on 150-500 mg 2 times a day for an individual scheme.
After 7-10 days, a teturamalcohol sample is taken (20-30 ml of 40% vodka after taking 500 mg of the drug), with a weak reaction, the dose of alcohol is increased by 10-20 ml (the maximum dose of vodka is 100-120 ml).
The sample is repeated after 1-2 days in the hospital and after 3-5 days on an outpatient basis, with the correction of doses of alcohol and / or the drug as needed.
In the future, you can use a maintenance dose of 150-200 mg per day for 1-3 years.
"Metallic" taste in the mouth, unpleasant smell (caused by carbon disulphide) in patients with colostomy, hepatitis, lower extremity polyneuropathy, neuropsychiatric disorders, memory loss, disorientation in time and space, asthenia, headache, skin allergic reactions.
Hypersensitivity, thyrotoxicosis, cardiovascular diseases in the stage of decompensation (including pronounced cardiosclerosis, cerebral arteriosclerosis, cerebral vessels pre-and post-infarction, aortic aneurysm, coronary insufficiency, arterial hypertension II-III stage, CHF), heart disease , bronchial asthma, COPD, severe pulmonary emphysema, erosive lesions of the gastrointestinal mucosa, peptic ulcer and 12 duodenal ulcers (in acute stage), bleeding from the gastrointestinal tract, kidney disease, liver failure, sugar di bet, epilepsy, neuro-psychiatric diseases, infectious CNS diseases, polyneuropathy, neuritis of the auditory and optic nerve, glaucoma, cancer, pregnancy, lactation. Age over 60 years, peptic ulcer and 12 duodenal ulcers (in remission), endarteritis, residual cerebrovascular events, psychosis in patients with disulfiram in history.
Contraindications
Alcohol: intolerance reaction (flushing, erythema, vomiting, tachycardia). Avoid alcohol and drugs containing alcohol.
Unwanted combinations
Isoniazid: impaired behavior and coordination.
Nitro-5-imidazoles (metronidazole, ordinazole, secnidazole, tinidazole): delirious disorders, confusion.
Phenytoin: a significant and rapid rise in the level of phenytoin in plasma with toxic symptoms (suppression of its metabolism).
If combinations cannot be avoided, clinical observation and control of drug concentrations in the plasma of the entry and after treatment with teturam should be carried out.
Combinations that require caution
Warfarin (and other oral anticoagulants): an increased effect of oral anticoagulants and the risk of bleeding (reduction of warfarin in the liver). More frequent monitoring of the concentration of warfarin and adjustment of the dose of anticoagulants within 8 days after discontinuation of teturam is recommended.
Theophylline: teturam inhibits theophylline metabolism. As a result of this, the dose of theophylline should be adjusted (reduced dosage), depending on the clinical symptoms and the plasma concentration of the drug.
Benzodiazepines: teturam can potentiate the sedative effect of benzodiazepines by inhibiting their oxidative metabolism (especially chlordiazepoxide and diazepam). Benzodiazepine dosage should be adjusted according to clinical manifestations.
Tricyclic antidepressants: it is possible to increase the reaction of intolerance to alcohol (especially if patients take teturam on the background, take alcoholic beverages).
Contraindicated during pregnancy and lactation.
Patients should be warned of the dangers of intolerance to alcohol. Teturam should be taken with caution in patients with renal insufficiency or hypothyroidism, especially at risk of a possible combination with alcohol.
Symptoms: the teturam-ethanol combination can cause depression of consciousness up to coma, cardiovascular collapse, neurological complications.
Treatment: symptomatic.