

The blocker H1-histamine receptors from the group of ethanolamines. The drug has a sedative, sedative and M-holinoblokiruyuschee effect. It reduces the time of sleep, increases the duration and quality of sleep, while not changing the phase of sleep. Duration of action - 6-8 hours.
Pharmacokinetics
Absorption - high, metabolized in the liver. It penetrates well through histohematogenous barriers (including the blood-brain barrier). Excreted in 60% of the kidneys in unchanged form, in part - through the digestive tract.
Sleep disturbances, insomnia.
Each coated tablet contains 15 mg of doxylamine succinate.
Excipients: lactose monohydrate, croscarmellose sodium, microcrystalline cellulose, magnesium stearate, hypromellose, pigment dispersion Sepispers AP 7001 (composition: hypromellose, titanium dioxide, propylene glycol, purified water), macrogol 6000, purified water.
Doxylamine is marketed under different brands and generic names, and comes in different dosage forms:
Brand name | Manufacturer | Country | Dosage form |
---|---|---|---|
pills | |||
Reslip | Obolensky OP | Russia | pills |
Valocordin-Doxylamine | Crevel Moiselbach GMBH | Germany | drops |
Donormyl | UPSA SAS | France | pills |
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For oral use. On 1/2 - 1 tablet a day, washing down with a small amount of liquid, 15-30 minutes before bedtime.
If treatment is ineffective, according to the recommendation of the doctor, the dose may be increased to two pills.
Duration of treatment from 2 to 5 days; If insomnia persists, you should consult a doctor.
From the gastrointestinal tract:
- Constipation, dry mouth;
From the side of the cardiovascular system:
- feeling of heartbeat;
On the part of the organ of vision:
- visual impairment and accommodation, blurred vision;
From the kidneys and urinary tract:
- urinary retention;
From the nervous system:
- daytime sleepiness (in this case, the dose of the drug should be reduced)
- confusion, hallucinations.
From the laboratory indicators:
- increase in creatine phosphokinase level;
From the musculoskeletal system:
- rhabdomyolysis.
If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects that are not indicated in the instruction, inform your doctor.
- Hypersensitivity to doxylamine and other components of the drug, or to other antihistamines;
- angle-closure glaucoma or a family history of angle-closure glaucoma;
- diseases of the urethra and prostate gland, accompanied by a violation of urine outflow;
- congenital galactosemia, glucose-galactose malabsorption, lactase deficiency;
- children and adolescents (up to 15 years).
Carefully
Patients with a history of apnea, due to the fact that doxylamine succinate may exacerbate the syndrome of sleep apnea (sudden respiratory depression during sleep). Patients older than 65 years - due to possible dizziness and delayed reactions with the danger of falls (for example, during night awakenings after taking sleeping pills), as well as in connection with a possible increase in the half-life.
Patients with renal and hepatic insufficiency (the half-life may increase).
While taking the drug thalidomide, baclofep, pizothiphene increases the inhibitory effect on the central nervous system (CNS).
When taken simultaneously with m-anticholinergic blocking agents (atropine, imipramine antidepressants, antiparkinsonic drugs, atropine antispasmodics, disopyramide, phenothiazine neuroleptics) increases the risk of such side effects as urinary retention, constipation, dry mouth.
Since alcohol enhances the sedative effect of most antagonists of H1-histamine receptors, incl. and the drug Donormyl, it is necessary to avoid its simultaneous use with alcoholic beverages and drugs that contain alcohol.
It should be borne in mind that insomnia can be caused by a number of reasons for which there is no need to prescribe this drug.
The drug has a sedative effect, suppresses cognitive abilities and slows down psychomotor reactions. The first generation of H 1- antihistamine drugs can have m-anticholinergic, anti-a-adrenergic and anti-serotonin effects, which can cause dry mouth, constipation, urinary retention, accommodation and vision problems.
Like all sleeping pills or sedatives, doxylamine succinate can exacerbate sleep apnea (sudden respiration in sleep), increasing the number and duration of sleep apnea.
One tablet of the drug contains 100 mg of lactose monohydrate, which should be taken into account in patients with rare congenital intolerance to galactose, Lappa lactase deficiency or glucose-galactose malabsorption.
Symptoms: daytime sleepiness, pupil dilation (mydriasis), facial flushing (redness), fever (hyperthermia), low mood, anxiety, impaired motor coordination, tremors (tremor), involuntary movements of the fingers and toes (athetosis), convulsions (epileptic syndrome), coma.
If symptoms of poisoning appear, you should immediately consult a doctor.
Treatment: symptomatic (m-cholinomimetics, etc.).
Studies and clinical trials of Doxylamine (Click to expand)