Buy Donormyl pills 15 mg 10 pcs
  • Buy Donormyl pills 15 mg 10 pcs


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Clinical Pharmacology

The blocker H1-histamine receptors from the group of ethanolamines. The drug has a sedative, sedative and M-holinoblokiruyuschee effect. It reduces the time of sleep, increases the duration and quality of sleep, while not changing the phase of sleep. Duration of action - 6-8 hours.

Absorption - high, metabolized in the liver. It penetrates well through histohematogenous barriers (including the blood-brain barrier). Excreted in 60% of the kidneys in unchanged form, in part - through the digestive tract.


Sleep disturbances, insomnia.


Each coated tablet contains 15 mg of doxylamine succinate.
Excipients: lactose monohydrate, croscarmellose sodium, microcrystalline cellulose, magnesium stearate, hypromellose, pigment dispersion Sepispers AP 7001 (composition: hypromellose, titanium dioxide, propylene glycol, purified water), macrogol 6000, purified water.

Doxylamine is marketed under different brands and generic names, and comes in different dosage forms:

Brand nameManufacturerCountryDosage form
Reslip Obolensky OP Russia pills
Valocordin-Doxylamine Crevel Moiselbach GMBH Germany drops
Donormyl UPSA SAS France pills

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Dosage and Administration

For oral use. On 1/2 - 1 tablet a day, washing down with a small amount of liquid, 15-30 minutes before bedtime.
If treatment is ineffective, according to the recommendation of the doctor, the dose may be increased to two pills.
Duration of treatment from 2 to 5 days; If insomnia persists, you should consult a doctor.

Adverse reactions

From the gastrointestinal tract:
- Constipation, dry mouth;
From the side of the cardiovascular system:
- feeling of heartbeat;
On the part of the organ of vision:
- visual impairment and accommodation, blurred vision;
From the kidneys and urinary tract:
- urinary retention;
From the nervous system:
- daytime sleepiness (in this case, the dose of the drug should be reduced)
- confusion, hallucinations.
From the laboratory indicators:
- increase in creatine phosphokinase level;
From the musculoskeletal system:
- rhabdomyolysis.
If any of the side effects indicated in the instruction are aggravated, or you have noticed any other side effects that are not indicated in the instruction, inform your doctor.


- Hypersensitivity to doxylamine and other components of the drug, or to other antihistamines;
- angle-closure glaucoma or a family history of angle-closure glaucoma;
- diseases of the urethra and prostate gland, accompanied by a violation of urine outflow;
- congenital galactosemia, glucose-galactose malabsorption, lactase deficiency;
- children and adolescents (up to 15 years).
Patients with a history of apnea, due to the fact that doxylamine succinate may exacerbate the syndrome of sleep apnea (sudden respiratory depression during sleep). Patients older than 65 years - due to possible dizziness and delayed reactions with the danger of falls (for example, during night awakenings after taking sleeping pills), as well as in connection with a possible increase in the half-life.
Patients with renal and hepatic insufficiency (the half-life may increase).

Drug interactions

While taking the drug thalidomide, baclofep, pizothiphene increases the inhibitory effect on the central nervous system (CNS).

When taken simultaneously with m-anticholinergic blocking agents (atropine, imipramine antidepressants, antiparkinsonic drugs, atropine antispasmodics, disopyramide, phenothiazine neuroleptics) increases the risk of such side effects as urinary retention, constipation, dry mouth.

Since alcohol enhances the sedative effect of most antagonists of H1-histamine receptors, incl. and the drug Donormyl, it is necessary to avoid its simultaneous use with alcoholic beverages and drugs that contain alcohol.

Special instructions

It should be borne in mind that insomnia can be caused by a number of reasons for which there is no need to prescribe this drug.

The drug has a sedative effect, suppresses cognitive abilities and slows down psychomotor reactions. The first generation of H 1- antihistamine drugs can have m-anticholinergic, anti-a-adrenergic and anti-serotonin effects, which can cause dry mouth, constipation, urinary retention, accommodation and vision problems.

Like all sleeping pills or sedatives, doxylamine succinate can exacerbate sleep apnea (sudden respiration in sleep), increasing the number and duration of sleep apnea.

One tablet of the drug contains 100 mg of lactose monohydrate, which should be taken into account in patients with rare congenital intolerance to galactose, Lappa lactase deficiency or glucose-galactose malabsorption.


Symptoms: daytime sleepiness, pupil dilation (mydriasis), facial flushing (redness), fever (hyperthermia), low mood, anxiety, impaired motor coordination, tremors (tremor), involuntary movements of the fingers and toes (athetosis), convulsions (epileptic syndrome), coma.

If symptoms of poisoning appear, you should immediately consult a doctor.
Treatment: symptomatic (m-cholinomimetics, etc.).

  • Brand name: Donormyl
  • Active ingredient: Doxylamine
  • Dosage form: Pills
  • Manufacturer: Rottapharm

Studies and clinical trials of Doxylamine (Click to expand)

  1. Quantitative chiral analysis of carbinoxamine, doxylamine, and orphenadrine by capillary zone electrophoresis
  2. Mass spectral characterization of doxylamine and its rhesus monkey urinary metabolites
  3. Desorption chemical ionization and fast atom bombardment mass spectrometric studies of the glucuronide metabolites of doxylamine
  4. Characterization of doxylamine and pyrilamine metabolites via thermospray/mass spectrometry and tandem mass spectrometry
  5. Separation and detection of doxylamine and its rhesus monkey urinary metabolites by high resolution gas chromatography utilizing nitrogen/phosphorus detection
  6. GC/MS characterization of urinary metabolites of doxylamine succinate: Identification of the aglycones formed from intestinal microflora metabolism of the polar glucuronide metabolites
  7. Synthesis of carbon-14 labeled doxylamine succinate
  8. Analysis of doxylamine in plasma by high-performance liquid chromatography
  9. Differential protonation and dynamic structure of doxylamine succinate in solution using 1H and 13C NMR
  10. Chemical ionization mass spectrometry of doxylamine and related compounds
  11. Chromatographic behavior of doxylamine succinate, phenylpropanolamine hydrochloride, chlorpheniramine maleate, dextromethorphan hydrobromide, paracetamol, and guaifenesin in ion pair reverse-phase high performance liquid chromatography
  12. Formation of artifactual metabolites of doxylamine following acid hydrolysis
  13. Formulation and evaluation of orodispersible tablet of taste masked doxylamine succinate using ion exchange resin
  14. The correlation of blood drug concentration between manner of death and cause of death: Doxylamine
  15. Suicide through doxylamine poisoning
  16. Assessment of doxylamine influence on mixed function oxidase activity upon multiple dose oral administration to normal volunteers
  17. Effects of doxylamine and acetaminophen on postoperative sleep
  18. Hair analysis for doxylamine
  19. Effects of Doxylamine Succinate on Thyroid Hormone Balance and Enzyme Induction in Mice
  20. A fatal complication of doxylamine in a 1-year-old girl
  21. Embryo-maternal distribution of basic compounds in the CD-1 mouse: Doxylamine and nicotine
  22. Effectiveness of delayed-release doxylamine and pyridoxine for nausea and vomiting of pregnancy: a randomized placebo controlled trial
  23. A comparative study of an in situ adapted diffusion cell and an in vitro Franz diffusion cell method for transdermal absorption of doxylamine
  24. The associative factors of delayed-onset rhabdomyolysis in patients with doxylamine overdose

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