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Dysport®

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Clinical Pharmacology

Dysport is a muscle relaxant. Clostridium botulinum type A toxin blocks the release of acetylcholine in the neuromuscular synapse, which leads to muscle relaxation in the area of ​​drug administration. Restoration of neuromuscular transmission occurs gradually, as new nerve endings are formed and contacts with the postsynaptic motor end plate are restored.
The effect of the drug lasts for 3-4 months.

Indications

For use in adults:
- blepharospasm;
- hemifacial spasm;
- spastic torticollis in adults;
- spasticity of the arm muscles after a stroke;
- hyperkinetic (facial) folds (wrinkles) of the face.
For use in children over 2 years old:
- dynamic deformity of the foot, caused by spasticity, with cerebral palsy.

Composition

active substance:botulinum toxin type A-hemagglutinin complex 500 U;

Excipients: human albumin - 125 mcg; lactose - 2.5 mg

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Dysport®

Dosage and Administration

The drug is prescribed 1-2 pills 3 times / day. During a long time.

pills should be taken 30 minutes before or 30 minutes after a meal, slowly dissolving them in the mouth.

- Installed hypersensitivity to bee venom.
- Pregnancy.

Drug interactions

Drug interaction drug Dysmenorm® with other drugs is not installed.

Pregnancy and Lactation

The drug is contraindicated for use in pregnancy. Use of the drug Dysmenorm® during lactation (breastfeeding) is possible only if the intended benefit to the mother outweighs the potential risk to the baby.

Special instructions

With the use of Dysmenorm, a temporary deterioration of the condition is possible. In this case, the patient should stop taking the drug and consult a doctor.

Overdosage

Currently, cases of drug overdose Dysmenorm® were reported.

  • Brand name: Dysmenorm®
  • Active ingredient: Homeopathic composition
  • Dosage form: Pills
  • Manufacturer: German Homeopathic Union
  • Country of Origin: Germany

Studies and clinical trials of Dysport (Click to expand)

  1. Efficacy and safety of botulinum type A toxin (Dysport) in cervical dystonia: Results of the first US randomized, double-blind, placebo-controlled study
  2. Retrospective evaluation of the dose of dysport and BOTOX in the management of cervical dystonia and blepharospasm: The REAL DOSE study
  3. Respective potencies of Botox® and Dysport® in a human skin model: A randomized, double-blind study
  4. DYSBOT: A single-blind, randomized parallel study to determine whether any differences can be detected in the efficacy and tolerability of two formulations of botulinum toxin type A—Dysport and Botox—assuming a ratio of 4:1
  5. Dose thresholds and local anhidrotic effect of botulinum A toxin injections (Dysport®)
  6. Chronic anal fissures treated with botulinum toxin injections: a dose-finding study with Dysport®
  7. Biological activity of two botulinum toxin type A complexes (Dysport®and Botox®) in volunteers
  8. Biological activity of two botulinum toxin type A complexes (Dysport®and Botox®) in volunteers
  9. Comparing biological potencies of Botox and Dysport with a mouse diaphragm model may mislead
  10. Hemifacial spasm and reinnervation synkinesias: long-term treatment with either Botox®or Dysport®
  11. Fifteen-Year Experience in Treating Blepharospasm with Botox or Dysport: Same Toxin, Two Drugs
  12. Botulinum neurotoxin to treat chronic anal fissure: results of a randomized ‘Botox vs. Dysport’ controlled trial
  13. A double-blind, randomized, comparative study of Dysport® vs. Botox® in primary palmar hyperhidrosis
  14. Immunological aspects of Botox®, Dysport® and MyoblocTM/NeuroBloc®
  15. Pericranial injection of botulinum toxin type A (Dysport®) for tension-type headache – A multicentre, double-blind, randomized, placebo-controlled study
  16. Outcome predictors, efficacy and safety of Botox and Dysport in the long-term treatment of hemifacial spasm
  17. Long-term efficacy and tolerability of 4-monthly versus yearly botulinum toxin type A treatment for lower-limb spasticity in children with cerebral palsy
  18. Prophylactic Botulinum Type A Toxin Complex (Dysport®) for Migraine Without Aura
  19. Botulinum Type A Toxin Complex for the Relief of Upper Back Myofascial Pain Syndrome: How Do Fixed-Location Injections Compare with Trigger Point-Focused Injections?
  20. Efficacy and safety of a standardised 500 unit dose of Dysport®(Clostridium botulinum toxin type A haemaglutinin complex) in a heterogeneous cervical dystonia population: results of a prospective, multicentre, randomised, double-blind, placebo-controlled, parallel group study
  21. Retrospective evaluation of the dose equivalence of Botox®and Dysport®in the management of blepharospasm and hemifacial spasm: a novel paradigm for a never ending story
  22. Botulinum Neurotoxin Type A-ABO (Dysport): Clinical Indications and Practice Guide
  23. Contemporary Management of Lower Urinary Tract Disease With Botulinum Toxin A: A Systematic Review of Botox (OnabotulinumtoxinA) and Dysport (AbobotulinumtoxinA)

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