Econazole
Yunik Pharmaceutical
945 Items
2019-09-19
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Clinical Pharmacology
Cream ECODAX - antifungal drug for local and external use. Is a derivative of imidazole. It has a fungicidal and bactericidal effect. It inhibits the biosynthesis of ergosterol, which regulates the permeability of the cell wall of microorganisms. It has a high activity against dermatophytes: Trichophyton rubrum, T.mentagrophytes, T.tonsurans, Microsporum canis, M.audouini, M.gypseum; yeast: Epidermophyton floccosum, Candida albicans, Malassezia furfur, Pitysporum orbiculare, Pitysporum ovale; mold fungi: Aspergillus, Cladosporium, Scopulariopsis brevicaulis. It also has activity against some gram-positive bacteria: Streptococcus spp., Staphylococcus spp., Bacillus subtilis, Bacillus anthracis, Actinomyces Israeli.
Indications
Mycoses of the skin (including damage to hairy areas) and mucous membranes.
Composition
1 g of the cream contains:
Active substance: econazole nitrate 10 mg;
Excipients: chlorocresol, disubstituted sodium phosphate dihydrate, phosphoric acid, white soft paraffin, liquid paraffin, cetostearyl alcohol, cetomacrogol-1000, sodium hydroxide, purified water.
Econazole is marketed under different brands and generic names, and comes in different dosage forms:
| Brand name | Manufacturer | Country | Dosage form |
|---|---|---|---|
| Ecodax | Yunik Pharmaceutical | India | cream |
| Gyno-pevaryl | Johnson and johnson | Ireland | suppositories |
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Dosage and Administration
Ecodax is applied with a thin layer 2 times a day on the affected skin and lightly rubbed. The disappearance of itching and redness is noted by the end of the first week of treatment. Duration of treatment is 2-4 weeks. In some cases (hyperkeratosis), the duration of treatment may be increased.
Adverse reactions
Local reactions: irritation, burning sensation and itching, redness of the skin, dry skin, rash; with prolonged use - hyperpigmentation and atrophic changes in the skin.
Contraindications
Hypersensitivity and individual intolerance to econazole, as well as other imidazole derivatives.
Pregnancy and Lactation
Use of the drug during pregnancy and lactation is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.
Special instructions
For external use only! Avoid eye contact!
- Brand name: Ecodax
- Active ingredient: Econazole
- Dosage form: Cream
- Manufacturer: Yunik Pharmaceutical
- Country of Origin: India
Studies and clinical trials of Econazole (Click to expand)
- Chiral Separation of Bencynonate and Econazole by Cyclodextrin-Modified Capillary Zone Electrophoresis
- Econazole-induced Ca2+ fluxes and apoptosis in human oral cancer cells
- Enhanced econazole penetration into human nail by 2-n-nonyl-1,3-dioxolane
- Econazole nitrate-loaded MCM-41 for an antifungal topical powder formulation
- Development and validation of a method for quantitative determination of econazole nitrate in cream formulation by capillary zone electrophoresis
- Analysis of miconazole and econazole in pharmaceutical formulations by derivative UV spectroscopy and liquid chromatography (HPLC)
- Synthesis and antitubercular activity of monocyclic nitroimidazoles: Insights from econazole
- Effect of lipid nanoparticles containing fatty alcohols having different chain length on the ex vivo skin permeability of Econazole nitrate
- Antioxidative natural product protect against econazole-induced liver injuries
- Characterization of autoxidation products of the antifungal compounds econazole nitrate and miconazole nitrate
- An econazole β-cyclodextrin inclusion complex: an unusual dissolution rate, supersaturation, and biological efficacy example
- Influence of the preparation method on the physicochemical properties of binary systems of econazole with cyclodextrins
- Comparative study of the enantiomeric resolution of chiral antifungal drugs econazole, miconazole and sulconazole by HPLC on various cellulose chiral columns in normal phase mode
- Evaluation of in vitro activity of ciclopirox olamine, butenafine HCl and econazole nitrate against dermatophytes, yeasts and bacteria
- The role of econazole in the management of oculomycosis
- Scanning and transmission electron microscopy: study of effects of econazole onMicrosporum canis
- Inhibitory effect of econazole on the release of thromboxanes
- Effects of econazole, fungizone and pimafucin on cell growth, lysosomal enzyme activity and sulphate metabolism of cultured human skin fibroblasts and amniotic fluid cells
- A Parenteral Econazole Formulation Using a Novel Micelle-to-Liposome Transfer Method:In VitroCharacterization and Tumor Growth Delay in a Breast Cancer Xenograft Model
- Inhibition of TRPM2 channels by the antifungal agents clotrimazole and econazole
- Ultrasound-enhanced surfactant-assisted dispersive liquid–liquid microextraction and high-performance liquid chromatography for determination of ketoconazole and econazole nitrate in human blood
- Comparison of the chiral resolution of econazole, miconazole, and sulconazole by HPLC using normal-phase amylose CSPs
- Experimental Study on Apoptosis in Leukemia Cells Induced by Econazole
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