Endofalk®
Dr. Falk
1271 Items
2019-09-19
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Clinical Pharmacology
Endofalk - has a laxative effect.
Pharmacodynamics
The laxative effect of Endofalc is due to the action of the ingredients in the preparation and is manifested in the occurrence of diarrhea. Macrogol 3350 (polyethylene glycol) due to the creation of an isosmolar solution prevents absorption in the stomach and intestines and contributes to the accelerated passage and removal of the contents of the gastrointestinal tract. The electrolytes of salts that are part of the drug, prevent disruption of the water-salt balance of the body.
Pharmacokinetics
High molecular weight polyethylene glycols are not absorbed from the gastrointestinal tract and are not metabolized during passageway (they prevent undesirable gas formation caused by the metabolizing action of bacteria).
Indications
Preparation for endoscopic or radiological examination of the lower intestine; preparation for surgical procedures, which require the absence of intestinal contents - chyme.
Composition
1 bag of powder contains (55.318 g):
Active substances: macrogol 3350 52.5 g, sodium chloride 1.4 g, sodium bicarbonate 0.715 g, potassium chloride 0.185 g;
Excipients: colloidal silicon dioxide - 0.00046 g; fruit flavoring - 0.4 g; orange flavor - 0.1 g; sodium saccharinate - 0,018 g
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Dosage and Administration
Endofalk is taken orally, adults and children over 18 years, in the form of a solution. The solution can be taken orally or administered through a nasogastric tube the night before or in the morning on the day of the intended examination or operation on the intestine. On the evening before and on the morning of the study, you should also refrain from eating.
To prepare 1 liter of the solution, the contents of 2 sachets are dissolved in 1/2 l of cooled boiled (purified) water, then the volume of the solution is adjusted to 1 l. For complete bowel cleansing, it is recommended to prepare and take at least 3 liters of Endofal solution. The time during which the solution is taken is 3-4 hours. The recommended dose is 3-4 liters of solution, taken in 200–300 ml portions every 10 minutes.
Adverse reactions
From the digestive tract: rarely - nausea, vomiting, flatulence, cramping pain; at the beginning and some time after taking - feeling of heaviness and discomfort in the abdomen; sleep disturbance; very rarely - allergic reactions.
From the side of the central nervous system: very rarely - sleep disturbance and general malaise.
Hypersensitivity Reactions: very rarely - allergic reactions.
If you find any of these effects, you should immediately consult with your doctor.
Contraindications
- severe violations of the patient’s general condition (dehydration, cardiac and / or renal failure);
- intestinal obstruction;
- toxic expansion of the colon;
- gastric stenosis;
- perforation of the stomach or intestines;
- erosive and ulcerative lesions of the digestive tract;
- severe colitis in the acute phase;
- impaired renal excretory function;
- children's age up to 18 years.
Drug interactions
The process of freeing the intestines from the contents, caused by the action of the drug, can lead to a violation of the absorption of other drugs taken simultaneously with it.
Pregnancy and Lactation
There is still no experience with the clinical use of Endofalk in pregnant women. Therefore, Endofalc should be prescribed during pregnancy and lactation only under strict indications.
Special instructions
If any side effects occur, you should consult with your doctor.
Not recommended for use in children.
Elderly patients with existing comorbidities are recommended to use the drug under medical supervision. The patient must inform the attending physician of all medications taken by him at the same time as Endofalc.
Influence on ability to steer vehicles and moving mechanisms. Not found.
- Brand name: Endofalk
- Active ingredient: Macrogol, Sodium Chloride, Sodium Bicarbonate, Potassium Chloride
- Dosage form: Powder for the preparation of oral solution
- Manufacturer: Dr. Falk
- Country of Origin: Germany
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